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38  structures 5048  species 6  interactions 8326  sequences 66  architectures

Clan: 5_3_exonuc_C (CL0464)

Summary

5'-3'-exonuclease C-terminal sub-region Add an annotation

This superfamily includes C-terminal domains from a number of DNA-processing enzymes including T4 RNase H, 5' to 3' exonuclease domain of DNA polymerase Taq, T5 5'-exonuclease, Flap endonuclease-1 (Fen-1 nuclease), and other eukaryotic endonucleases.

This clan contains 4 families and the total number of domains in the clan is 8326. The clan was built by P Coggill.

Members

This clan contains the following 4 member families:

5_3_exonuc RNaseH_C XPG_I XPG_I_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
5_3_exonuc (PF01367) 6018 (72.3%) View
XPG_I (PF00867) 2052 (24.6%) View
XPG_I_2 (PF12813) 211 (2.5%) View
RNaseH_C (PF09293) 45 (0.5%) View
Total: 4 Total: 8326 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 6 interactions for this clan. More...

Interacting families
A B
5_3_exonuc DNA_pol_A
5_3_exonuc_N
RNaseH_C 5_3_exonuc_N
XPG_I XPG_N
XPG_I
PCNA_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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