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530  structures 4822  species 22  interactions 41246  sequences 867  architectures

Clan: 6_Hairpin (CL0059)

Summary

Six-hairpin glycosidase superfamily Add an annotation

This Clan includes CAZy clans GH-L, GH-M and GH-G. The members of this clan share a common structure composed of 6 helical hairpins. Most members of this superfamily are glycosyl hydrolase enzymes.

This clan contains 28 families and the total number of domains in the clan is 41246. The clan was built by A Bateman.

Members

This clan contains the following 28 member families:

A2M_comp Bac_rhamnosid C5-epim_C Cobalamin_bind DUF1237 DUF1680 DUF2807 DUF4097 DUF4098 DUF608 GDE_C GlcNAc_2-epim Glyco_hydro_100 Glyco_hydro_15 Glyco_hydro_47 Glyco_hydro_48 Glyco_hydro_63 Glyco_hydro_65m Glyco_hydro_76 Glyco_hydro_8 Glyco_hydro_88 Glyco_hydro_9 Glycoamylase Pec_lyase Prenyltrans Prenyltrans_1 Prenyltrans_2 Trehalase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DUF4098 (PF13345) 4531 (11.0%) View
Prenyltrans_2 (PF13249) 3084 (7.5%) View
Trehalase (PF01204) 2673 (6.5%) View
Glyco_hydro_15 (PF00723) 2515 (6.1%) View
Prenyltrans (PF00432) 2497 (6.1%) View
Glyco_hydro_88 (PF07470) 2447 (5.9%) View
Glyco_hydro_9 (PF00759) 1983 (4.8%) View
Glyco_hydro_65m (PF03632) 1977 (4.8%) View
Glyco_hydro_47 (PF01532) 1956 (4.7%) View
GlcNAc_2-epim (PF07221) 1825 (4.4%) View
A2M_comp (PF07678) 1721 (4.2%) View
DUF4097 (PF13349) 1584 (3.8%) View
DUF1680 (PF07944) 1388 (3.4%) View
Bac_rhamnosid (PF05592) 1344 (3.3%) View
Glyco_hydro_76 (PF03663) 1340 (3.2%) View
continued
Pfam family Num. domains Alignment
Glyco_hydro_8 (PF01270) 1235 (3.0%) View
GDE_C (PF06202) 1196 (2.9%) View
DUF1237 (PF06824) 1064 (2.6%) View
DUF2807 (PF10988) 860 (2.1%) View
Prenyltrans_1 (PF13243) 810 (2.0%) View
Glycoamylase (PF10091) 731 (1.8%) View
Glyco_hydro_63 (PF03200) 722 (1.8%) View
DUF608 (PF04685) 661 (1.6%) View
Glyco_hydro_100 (PF12899) 347 (0.8%) View
Glyco_hydro_48 (PF02011) 213 (0.5%) View
Pec_lyase (PF09492) 198 (0.5%) View
C5-epim_C (PF06662) 182 (0.4%) View
Cobalamin_bind (PF01122) 162 (0.4%) View
Total: 28 Total: 41246 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 22 interactions for this clan. More...

Interacting families
A B
GlcNAc_2-epim GlcNAc_2-epim
Glyco_hydro_48 Glyco_hydro_48
Glyco_hydro_88 Glyco_hydro_88
Glyco_hydro_9 Glyco_hydro_9
CBM_3
CelD_N
Prenyltrans Prenyltrans
PPTA
RabGGT_insert
Glyco_hydro_15 Glyco_hydro_15
Glucodextran_B
Glucodextran_N
Glyco_hydro_47 Glyco_hydro_47
Bac_rhamnosid Bac_rhamnosid
Bac_rhamnosid_N
DUF1237 DUF1237
Pec_lyase Pec_lyase
A2M_comp Sushi
A2M_N
A2M_recep
A2M_comp
Thiol-ester_cl

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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