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3  structures 5481  species 0  interactions 49701  sequences 239  architectures

Clan: ABC-2 (CL0181)

Summary

ABC-2-transporter-like clan Add an annotation

These families are similar to the ABC-2 transporter subfamily, as described in [1] (Pfam:PF01061). Members of this family are involved in drug transport and resistance. CcmB protein family (Pfam:PF03379) members are also transporters; they are required for haem export into the periplasm [2].

This clan contains 10 families and the total number of domains in the clan is 49701. The clan was built by M Fenech.

Literature references

  1. Reizer J, Reizer A, Saier MH Jr; , Protein Sci 1992;1:1326-1332.: A new subfamily of bacterial ABC-type transport systems catalyzing export of drugs and carbohydrates. PUBMED:1303751 EPMC:1303751
  2. Thony-Meyer L, Fischer F, Kunzler P, Ritz D, Hennecke H; , J Bacteriol 1995;177:4321-4326.: Escherichia coli genes required for cytochrome c maturation. PUBMED:7635817 EPMC:7635817

Members

This clan contains the following 10 member families:

ABC2_membrane ABC2_membrane_2 ABC2_membrane_3 ABC2_membrane_4 ABC2_membrane_5 ABC2_membrane_6 CcmB DUF3526 DUF3533 PDR_CDR

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ABC2_membrane_3 (PF12698) 16168 (32.5%) View
ABC2_membrane (PF01061) 15925 (32.0%) View
ABC2_membrane_4 (PF12730) 7890 (15.9%) View
ABC2_membrane_2 (PF12679) 2420 (4.9%) View
ABC2_membrane_6 (PF06182) 2005 (4.0%) View
CcmB (PF03379) 1869 (3.8%) View
ABC2_membrane_5 (PF13346) 1444 (2.9%) View
PDR_CDR (PF06422) 1227 (2.5%) View
DUF3533 (PF12051) 601 (1.2%) View
DUF3526 (PF12040) 152 (0.3%) View
Total: 10 Total: 49701 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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