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1989  structures 7428  species 30  interactions 180167  sequences 2396  architectures

Clan: AB_hydrolase (CL0028)

Summary

Alpha/Beta hydrolase fold Add an annotation

This catalytic domain is found in a very wide range of enzymes.

This clan contains 67 families and the total number of domains in the clan is 180167. The clan was built by A Bateman.

Literature references

  1. Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag J, Sussman JL, Verschueren KHG, Goldman A; , Protein Eng 1992;5:197-211.: The alpha/beta hydrolase fold PUBMED:1409539 EPMC:1409539

Members

This clan contains the following 67 member families:

Abhydro_lipase Abhydrolase_1 Abhydrolase_2 Abhydrolase_3 Abhydrolase_4 Abhydrolase_5 Abhydrolase_6 Abhydrolase_7 Abhydrolase_8 Acyl_transf_2 Arb2 AXE1 BAAT_C Chlorophyllase Chlorophyllase2 COesterase Cutinase DLH DUF1057 DUF1100 DUF1350 DUF1400 DUF1749 DUF2048 DUF2235 DUF2305 DUF2424 DUF2920 DUF2974 DUF3089 DUF3141 DUF3530 DUF452 DUF676 DUF726 DUF818 DUF829 DUF900 DUF915 EHN Esterase Esterase_phd FSH1 Hydrolase_4 LCAT LIP Lipase Lipase_2 Lipase_3 Ndr PAF-AH_p_II Palm_thioest PE-PPE Peptidase_S10 Peptidase_S15 Peptidase_S28 Peptidase_S37 Peptidase_S9 PGAP1 PhaC_N PHB_depo_C PhoPQ_related Ser_hydrolase Tannase Thioesterase UPF0227 VirJ

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Abhydrolase_6 (PF12697) 53202 (29.5%) View
Abhydrolase_5 (PF12695) 16512 (9.2%) View
Abhydrolase_3 (PF07859) 13075 (7.3%) View
Esterase (PF00756) 9472 (5.3%) View
Peptidase_S9 (PF00326) 9052 (5.0%) View
Abhydrolase_1 (PF00561) 9019 (5.0%) View
COesterase (PF00135) 8736 (4.8%) View
Thioesterase (PF00975) 5677 (3.2%) View
DLH (PF01738) 4591 (2.5%) View
Lipase_3 (PF01764) 3914 (2.2%) View
Peptidase_S10 (PF00450) 3902 (2.2%) View
Abhydrolase_2 (PF02230) 2930 (1.6%) View
Peptidase_S15 (PF02129) 2545 (1.4%) View
Lipase (PF00151) 1975 (1.1%) View
UPF0227 (PF05728) 1870 (1.0%) View
Cutinase (PF01083) 1537 (0.9%) View
Hydrolase_4 (PF12146) 1506 (0.8%) View
Abhydro_lipase (PF04083) 1362 (0.8%) View
Peptidase_S28 (PF05577) 1264 (0.7%) View
PGAP1 (PF07819) 1253 (0.7%) View
DUF2235 (PF09994) 1245 (0.7%) View
Ser_hydrolase (PF06821) 1243 (0.7%) View
PhaC_N (PF07167) 1217 (0.7%) View
Abhydrolase_4 (PF08386) 1197 (0.7%) View
DUF676 (PF05057) 1193 (0.7%) View
DUF915 (PF06028) 1150 (0.6%) View
Esterase_phd (PF10503) 1139 (0.6%) View
LCAT (PF02450) 1122 (0.6%) View
LIP (PF03583) 1102 (0.6%) View
EHN (PF06441) 1051 (0.6%) View
AXE1 (PF05448) 1046 (0.6%) View
DUF2974 (PF11187) 1013 (0.6%) View
FSH1 (PF03959) 906 (0.5%) View
Tannase (PF07519) 801 (0.4%) View
continued
Pfam family Num. domains Alignment
DUF2920 (PF11144) 738 (0.4%) View
DUF1100 (PF06500) 738 (0.4%) View
Ndr (PF03096) 725 (0.4%) View
PE-PPE (PF08237) 715 (0.4%) View
BAAT_C (PF08840) 605 (0.3%) View
Palm_thioest (PF02089) 572 (0.3%) View
DUF726 (PF05277) 559 (0.3%) View
Abhydrolase_8 (PF06259) 556 (0.3%) View
DUF829 (PF05705) 555 (0.3%) View
PHB_depo_C (PF06850) 544 (0.3%) View
DUF900 (PF05990) 508 (0.3%) View
Lipase_2 (PF01674) 461 (0.3%) View
PAF-AH_p_II (PF03403) 427 (0.2%) View
Arb2 (PF09757) 409 (0.2%) View
DUF452 (PF04301) 358 (0.2%) View
DUF2305 (PF10230) 346 (0.2%) View
VirJ (PF06057) 339 (0.2%) View
PhoPQ_related (PF10142) 293 (0.2%) View
DUF1400 (PF07176) 255 (0.1%) View
DUF2048 (PF09752) 211 (0.1%) View
DUF1749 (PF08538) 206 (0.1%) View
DUF1350 (PF07082) 176 (0.1%) View
DUF3530 (PF12048) 175 (0.1%) View
DUF3141 (PF11339) 171 (0.1%) View
DUF2424 (PF10340) 116 (0.1%) View
Abhydrolase_7 (PF12715) 102 (0.1%) View
DUF3089 (PF11288) 100 (0.1%) View
Peptidase_S37 (PF05576) 98 (0.1%) View
Chlorophyllase2 (PF12740) 87 (0.0%) View
Acyl_transf_2 (PF02273) 59 (0.0%) View
DUF818 (PF05677) 50 (0.0%) View
Chlorophyllase (PF07224) 48 (0.0%) View
DUF1057 (PF06342) 46 (0.0%) View
Total: 67 Total: 180167 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

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Species distribution

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Interactions

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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