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20  structures 2219  species 1  interaction 4183  sequences 48  architectures

Clan: AIG2 (CL0278)

Summary

AIG2/ChaC-like superfamily Add an annotation

The structure consists of a five-stranded beta-barrel surrounded by two alpha-helices and a small beta-sheet. Conservation of residues in a hydrophilic cavity able to bind small ligands in some members suggests that this may also serve as an active site.

This clan contains 3 families and the total number of domains in the clan is 4183. The clan was built by A Bateman.

Literature references

  1. Lytle BL, Peterson FC, Tyler EM, Newman CL, Vinarov DA, Markley JL, Volkman BF; , Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006;62:490-493.: Solution structure of Arabidopsis thaliana protein At5g39720.1, a member of the AIG2-like protein family. PUBMED:16754964 EPMC:16754964
  2. Aramini JM, Swapna GV, Huang YJ, Rajan PK, Xiao R, Shastry R, Acton TB, Cort JR, Kennedy MA, Montelione GT; , J Biomol NMR. 2005;33:197-197.: 1H, 13C, and 15N resonance assignments for Escherichia coli ytfP, a member of the broadly conserved UPF0131 protein domain family. PUBMED:16331424 EPMC:16331424

Members

This clan contains the following 3 member families:

AIG2 AIG2_2 ChaC

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AIG2 (PF06094) 2098 (50.2%) View
ChaC (PF04752) 1371 (32.8%) View
AIG2_2 (PF13772) 714 (17.1%) View
Total: 3 Total: 4183 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
AIG2 AIG2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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