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2  structures 304  species 0  interactions 2924  sequences 129  architectures

Clan: AVL9 (CL0330)

Summary

Late secretory pathway transport machinery Add an annotation

Members of this clan are involved in vesicle formation/trafficking.

This clan contains 5 families and the total number of domains in the clan is 2924. The clan was built by A Bateman.

Literature references

  1. Harsay E, Schekman R; , Mol Biol Cell. 2007;18:1203-1219.: Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway. PUBMED:17229886 EPMC:17229886
  2. Allaire PD, Ritter B, Thomas S, Burman JL, Denisov AY, Legendre-Guillemin V, Harper SQ, Davidson BL, Gehring K, McPherson PS;, J Neurosci. 2006;26:13202-13212.: Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis. PUBMED:17182770 EPMC:17182770

Members

This clan contains the following 5 member families:

Afi1 Avl9 DENN DUF2347 SPA

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DENN (PF02141) 1791 (61.3%) View
SPA (PF08616) 396 (13.5%) View
Avl9 (PF09794) 380 (13.0%) View
DUF2347 (PF09804) 201 (6.9%) View
Afi1 (PF07792) 156 (5.3%) View
Total: 5 Total: 2924 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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