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664  structures 6524  species 5  interactions 128815  sequences 967  architectures

Clan: Acetyltrans (CL0257)

Summary

N-acetyltransferase like Add an annotation

This clan contains families related to N-acetyltransferases. N-acetyltransferases catalyse the transfer of acetyl groups from acetyl-CoA to arylamines.

This clan contains 31 families and the total number of domains in the clan is 128815. The clan was built by J Mistry.

Literature references

  1. Chinenov Y; , Trends Biochem Sci 2002;27:115-117.: A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity?. PUBMED:11893502 EPMC:11893502
  2. Kelley M, Vessey DA; , Biochem J 1992;288:315-317.: Structural comparison between the mitochondrial aralkyl-CoA and arylacetyl-CoA N-acyltransferases. PUBMED:1445276 EPMC:1445276

Members

This clan contains the following 31 member families:

Acetyltransf_1 Acetyltransf_10 Acetyltransf_13 Acetyltransf_3 Acetyltransf_4 Acetyltransf_5 Acetyltransf_6 Acetyltransf_7 Acetyltransf_8 Acetyltransf_9 Acetyltransf_CG ATE_C ATE_N Autoind_synth DUF1248 DUF1999 DUF2156 DUF3749 DUF482 DUF619 FemAB FR47 Gly_acyl_tr_C GNAT_acetyltr_2 GNAT_acetyltran Leu_Phe_trans Mec-17 Mig-14 MOZ_SAS NMT NodA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Acetyltransf_1 (PF00583) 50804 (39.4%) View
Acetyltransf_3 (PF13302) 20736 (16.1%) View
Acetyltransf_7 (PF13508) 13825 (10.7%) View
Acetyltransf_10 (PF13673) 6639 (5.2%) View
Acetyltransf_4 (PF13420) 5238 (4.1%) View
Acetyltransf_9 (PF13527) 3978 (3.1%) View
Acetyltransf_8 (PF13523) 3083 (2.4%) View
FemAB (PF02388) 2929 (2.3%) View
DUF2156 (PF09924) 2342 (1.8%) View
Acetyltransf_CG (PF14542) 2309 (1.8%) View
Leu_Phe_trans (PF03588) 2004 (1.6%) View
Acetyltransf_6 (PF13480) 1584 (1.2%) View
Acetyltransf_5 (PF13444) 1571 (1.2%) View
ATE_C (PF04377) 1296 (1.0%) View
GNAT_acetyltr_2 (PF13718) 1293 (1.0%) View
MOZ_SAS (PF01853) 1290 (1.0%) View
continued
Pfam family Num. domains Alignment
ATE_N (PF04376) 1240 (1.0%) View
NodA (PF02474) 1084 (0.8%) View
FR47 (PF08445) 870 (0.7%) View
DUF482 (PF04339) 853 (0.7%) View
Autoind_synth (PF00765) 807 (0.6%) View
DUF3749 (PF12568) 619 (0.5%) View
NMT (PF01233) 493 (0.4%) View
GNAT_acetyltran (PF12746) 486 (0.4%) View
DUF619 (PF04768) 416 (0.3%) View
Acetyltransf_13 (PF13880) 326 (0.3%) View
Mig-14 (PF07395) 242 (0.2%) View
Mec-17 (PF05301) 201 (0.2%) View
Gly_acyl_tr_C (PF08444) 176 (0.1%) View
DUF1248 (PF06852) 63 (0.0%) View
DUF1999 (PF09390) 18 (0.0%) View
Total: 31 Total: 128815 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
Acetyltransf_1 Acetyltransf_1
AA_kinase
DUF2156 DUF2156
NMT NMT
NMT_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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