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1022  structures 11461  species 37  interactions 141414  sequences 508  architectures

Clan: Actin_ATPase (CL0108)

Summary

Actin-like ATPase Superfamily Add an annotation

The actin-like ATPase domain forms an alpha/beta canonical fold. The domain can be subdivided into 1A, 1B, 2A and 2B subdomains. Subdomains 1A and 1B share the same RNAseH-like fold (a five-stranded beta-sheet decorated by a number of alpha-helices). Domains 1A and 2A are conserved in all members of this superfamily, whereas domain 1B and 2B have a variable structure and are even missing from some homologues [1]. Within the actin-like ATPase domain the ATP-binding site is highly conserved. The phosphate part of the ATP is bound in a cleft between subdomains 1A and 2A, whereas the adenosine moiety is bound to residues from domains 2A and 2B[1].

This clan contains 29 families and the total number of domains in the clan is 141414. The clan was built by RD Finn.

Literature references

  1. Abendroth J, Bagdasarian M, Sandkvist M, Hol WG; , J Mol Biol 2004;344:619-633.: The structure of the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae: an unusual member of the actin-like ATPase superfamily. PUBMED:15533433 EPMC:15533433

Members

This clan contains the following 29 member families:

Acetate_kinase Actin BcrAD_BadFG CmcH_NodU DDR DUF1464 DUF1786 EutA FGGY_C FGGY_N FtsA Fumble GDA1_CD39 Glucokinase Hexokinase_1 Hexokinase_2 HSP70 Hydant_A_N Hydantoinase_A MreB_Mbl MutL Pan_kinase Peptidase_M22 PilM_2 Ppx-GppA ROK StbA T2SL UPF0075

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HSP70 (PF00012) 23002 (16.3%) View
ROK (PF00480) 15339 (10.8%) View
Actin (PF00022) 15168 (10.7%) View
FGGY_N (PF00370) 14797 (10.5%) View
FGGY_C (PF02782) 14710 (10.4%) View
Peptidase_M22 (PF00814) 9668 (6.8%) View
FtsA (PF14450) 7122 (5.0%) View
Acetate_kinase (PF00871) 6003 (4.2%) View
Ppx-GppA (PF02541) 5020 (3.5%) View
MreB_Mbl (PF06723) 4314 (3.1%) View
BcrAD_BadFG (PF01869) 4290 (3.0%) View
Hydantoinase_A (PF01968) 2437 (1.7%) View
Hydant_A_N (PF05378) 2308 (1.6%) View
Pan_kinase (PF03309) 2298 (1.6%) View
UPF0075 (PF03702) 2041 (1.4%) View
continued
Pfam family Num. domains Alignment
Hexokinase_2 (PF03727) 1869 (1.3%) View
Hexokinase_1 (PF00349) 1806 (1.3%) View
Glucokinase (PF02685) 1646 (1.2%) View
GDA1_CD39 (PF01150) 1515 (1.1%) View
Fumble (PF03630) 1080 (0.8%) View
T2SL (PF05134) 962 (0.7%) View
PilM_2 (PF11104) 952 (0.7%) View
CmcH_NodU (PF02543) 743 (0.5%) View
StbA (PF06406) 732 (0.5%) View
EutA (PF06277) 699 (0.5%) View
DDR (PF08841) 375 (0.3%) View
MutL (PF13941) 371 (0.3%) View
DUF1786 (PF08735) 82 (0.1%) View
DUF1464 (PF07318) 65 (0.0%) View
Total: 29 Total: 141414 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 37 interactions for this clan. More...

Interacting families
A B
Hexokinase_2 Hexokinase_1
Hexokinase_2
Peptidase_M22 Peptidase_M22
HSP70 HSP70
Glucokinase Glucokinase
FGGY_N PTS_EIIA_1
FGGY_N
FGGY_C
Actin Actin
Myosin_head
Profilin
Serum_albumin
CH
WD40
Gelsolin
FH2
WH2
Exo_endo_phos
P34-Arc
P21-Arc
P16-Arc
ARPC4
VitD-bind_III
DDR DDR
StbA StbA
Fumble Fumble
ROK ROK
Acetate_kinase Acetate_kinase
Pan_kinase Pan_kinase
Ppx-GppA Ppx-GppA
FGGY_C PTS_EIIA_1
FGGY_N
FGGY_C
BcrAD_BadFG BcrAD_BadFG
MreB_Mbl SHS2_FTSA
Hexokinase_1 Hexokinase_1
Hexokinase_2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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