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20  structures 181  species 3  interactions 342  sequences 31  architectures

Clan: Bacteriocin_TLN (CL0446)

Summary

Translocation domain of colicin-like bacteriocins Add an annotation

A number of different bacterial species produce bacteriocins to kill competitor species, and the colicin class is a group of complex three-domain structures. The receptor-binding domain recognises and binds to specific cell surface receptors on the target cells; the N-terminal translocation domain interacts with cell membrane proteins to gain access to the cell interior; the C-terminal domain specifies a killing activity, such as pore formation or nuclease activity. This superfamily is a collection of the translocating domains.

This clan contains 2 families and the total number of domains in the clan is 342. The clan was built by P Coggill.

Literature references

  1. Soelaiman S, Jakes K, Wu N, Li C, Shoham M;, Mol Cell. 2001;8:1053-1062.: Crystal structure of colicin E3: implications for cell entry and ribosome inactivation. PUBMED:11741540 EPMC:11741540
  2. Chavan M, Rafi H, Wertz J, Goldstone C, Riley MA;, J Mol Evol. 2005;60:546-556.: Phage associated bacteriocins reveal a novel mechanism for bacteriocin diversification in Klebsiella. PUBMED:15883889 EPMC:15883889

Members

This clan contains the following 2 member families:

Cloacin Pyocin_S

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Pyocin_S (PF06958) 258 (75.4%) View
Cloacin (PF03515) 84 (24.6%) View
Total: 2 Total: 342 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
Cloacin Colicin
Cloacin_immun
E2R135

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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