Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
58  structures 353  species 4  interactions 2801  sequences 39  architectures

Clan: CHCH (CL0351)

Summary

Coiled-coil helix coiled-coil helix superfamily Add an annotation

The conserved [coiled coil 1]-[helix 1]-[coiled coil 2]-[helix 2] domain (CHCH domain) superfamily members include NADH-ubiquinone oxidoreductases, some cytochrome oxidases and yeast mitochondrial ribosomal proteins. Within each helix of the CHCH domain there are two cysteines present in a C-X9-C motif.

This clan contains 6 families and the total number of domains in the clan is 2801. The clan was built by A Bateman.

Members

This clan contains the following 6 member families:

CHCH Cmc1 COX6B DUF1903 NDUF_B7 Ndufs5

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CHCH (PF06747) 994 (35.5%) View
COX6B (PF02297) 675 (24.1%) View
Cmc1 (PF08583) 511 (18.2%) View
NDUF_B7 (PF05676) 256 (9.1%) View
DUF1903 (PF08991) 194 (6.9%) View
Ndufs5 (PF10200) 171 (6.1%) View
Total: 6 Total: 2801 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
COX6B COX1
COX2
COX3
COX6B

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...