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30  structures 396  species 2  interactions 10495  sequences 728  architectures

Clan: C1 (CL0006)

Summary

Protein kinase C, C1 domain Add an annotation

The members of this clan are all variations of the protein kinase C1 domain that is characterised by a rich cysteine and histidine content. The C1 domain is the N-terminal region of conservation found in protein kinase C domains. This domain is involved in binding many ligands, which include diacylglycerol, phorbol esters and zinc [1].

This clan contains 5 families and the total number of domains in the clan is 10495. The clan was built by RD Finn.

Literature references

  1. Azzi A, Boscoboinik D, Hensey C; , Eur J Biochem 1992;208:547-557.: The protein kinase C family. PUBMED:1396661 EPMC:1396661

Members

This clan contains the following 5 member families:

C1_1 C1_2 C1_3 C1_4 ZZ

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
C1_1 (PF00130) 6123 (58.3%) View
ZZ (PF00569) 2746 (26.2%) View
C1_3 (PF07649) 800 (7.6%) View
C1_2 (PF03107) 558 (5.3%) View
C1_4 (PF07975) 268 (2.6%) View
Total: 5 Total: 10495 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
C1_1 SH2
RhoGAP

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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