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312  structures 5344  species 4  interactions 38636  sequences 491  architectures

Clan: KH (CL0007)

Summary

K-Homology (KH) domain Superfamily Add an annotation

The KH domain is thought to be the second most prevalent RNA binding motif in proteins. The motif is characterised by a conserved GXXXGXXG in the middle of the domain. Structures of KH reveal that the KH domain is arranged as either a beta-alpha-alpha-beta-beta (mini-KH domain) or beta-alpha-alpha-beta-beta-alpha (maxi-KH domain). The secondary elements are separated by at least four loop segments. The second loop is located between beta-1 and al The KH domain can be found either as single or multiple copies. The KH domain usually binds RNA as a multimer.

This clan contains 5 families and the total number of domains in the clan is 38636. The clan was built by RD Finn.

Members

This clan contains the following 5 member families:

KH_1 KH_2 KH_3 KH_4 KH_5

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
KH_1 (PF00013) 19558 (50.6%) View
KH_2 (PF07650) 9989 (25.9%) View
KH_5 (PF13184) 4542 (11.8%) View
KH_4 (PF13083) 3577 (9.3%) View
KH_3 (PF13014) 970 (2.5%) View
Total: 5 Total: 38636 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
KH_2 MMR_HSR1
KH_1 KH_1
S1
RNase_PH

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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