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961  structures 5474  species 14  interactions 58501  sequences 303  architectures

Clan: Beta-lactamase (CL0013)

Summary

Serine beta-lactamase-like superfamily Add an annotation

This superfamily contains proteins that have a beta-lactamase fold. This includes beta-lactamases as well as Dala-Dala carboxypeptidases and glutaminases.

This clan contains 7 families and the total number of domains in the clan is 58501. The clan was built by RD Finn and A Bateman.

Members

This clan contains the following 7 member families:

Beta-lactamase Beta-lactamase2 DAP_B Glutaminase Peptidase_S11 Peptidase_S13 Transpeptidase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Transpeptidase (PF00905) 25088 (42.9%) View
Beta-lactamase (PF00144) 13942 (23.8%) View
Peptidase_S11 (PF00768) 8726 (14.9%) View
Beta-lactamase2 (PF13354) 5244 (9.0%) View
Peptidase_S13 (PF02113) 2907 (5.0%) View
Glutaminase (PF04960) 2528 (4.3%) View
DAP_B (PF07930) 66 (0.1%) View
Total: 7 Total: 58501 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 14 interactions for this clan. More...

Interacting families
A B
Glutaminase Glutaminase
Peptidase_S13 Peptidase_S13
DAP_B Beta-lactamase
DAP_C
Peptidase_S11 Peptidase_S11
PBP5_C
DUF1958
Beta-lactamase Beta-lactamase
DAP_B
DAP_C
Transpeptidase Transpeptidase
Transgly
PBP_dimer
PASTA

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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