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3279  structures 9586  species 29  interactions 173964  sequences 6514  architectures

Clan: PKinase (CL0016)

Summary

Protein kinase superfamily Add an annotation

This superfamily includes the Serine/Threonine- and Tyrosine- protein kinases as well as related kinases that act on non-protein substrates.

This clan contains 19 families and the total number of domains in the clan is 173964. The clan was built by DJ Studholme.

Literature references

  1. Hanks SK, Quinn AM; , Methods Enzymol 1991;200:38-62.: Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. PUBMED:1956325 EPMC:1956325
  2. Hanks SK, Hunter T; , FASEB J 1995;9:576-596.: Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. PUBMED:7768349 EPMC:7768349
  3. Hunter T, Plowman GD; , Trends Biochem Sci 1997;22:18-22.: The protein kinases of budding yeast: six score and more. PUBMED:9020587 EPMC:9020587

Members

This clan contains the following 19 member families:

ABC1 APH APH_6_hur Choline_kinase DUF1679 DUF2252 EcKinase Fructosamin_kin Kdo Kinase-like PIP49_C Pkinase Pkinase_Tyr Pox_ser-thr_kin RIO1 Seadorna_VP7 UL97 WaaY YrbL-PhoP_reg

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Pkinase (PF00069) 114309 (65.7%) View
Pkinase_Tyr (PF07714) 24806 (14.3%) View
APH (PF01636) 16611 (9.5%) View
ABC1 (PF03109) 5521 (3.2%) View
Kdo (PF06293) 2201 (1.3%) View
Fructosamin_kin (PF03881) 2015 (1.2%) View
Choline_kinase (PF01633) 1798 (1.0%) View
EcKinase (PF02958) 1726 (1.0%) View
RIO1 (PF01163) 1707 (1.0%) View
APH_6_hur (PF04655) 681 (0.4%) View
DUF2252 (PF10009) 553 (0.3%) View
WaaY (PF06176) 512 (0.3%) View
YrbL-PhoP_reg (PF10707) 504 (0.3%) View
PIP49_C (PF12260) 397 (0.2%) View
UL97 (PF06734) 208 (0.1%) View
DUF1679 (PF07914) 190 (0.1%) View
Kinase-like (PF14531) 140 (0.1%) View
Pox_ser-thr_kin (PF05445) 74 (0.0%) View
Seadorna_VP7 (PF07387) 11 (0.0%) View
Total: 19 Total: 173964 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 29 interactions for this clan. More...

Interacting families
A B
Pkinase_Tyr SH2
SH3_1
Y_phosphatase
FERM_M
Pkinase_Tyr
BPS
APH APH
Pkinase Ank
cNMP_binding
Pkinase
Cyclin_N
FKBP_C
Pkinase_C
S1
RGS
UBA
PBD
CKS
CK_II_beta
CDI
Cyclin_C
CDKN3
Ribonuc_2-5A
I-set
TGF_beta_GS
Cyclin
K-cyclin_vir_C
Herp-Cyclin
Choline_kinase Choline_kinase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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