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223  structures 1178  species 8  interactions 26677  sequences 1167  architectures

Clan: POZ (CL0033)

Summary

POZ domain superfamily Add an annotation

The POZ domain is found in a variety of transcription factors. POZ domains are also found in the tetramerisation domain of voltage gated K+ channels. In general these domains mediate homo-oligomerisation.

This clan contains 5 families and the total number of domains in the clan is 26677. The clan was built by A Bateman.

Literature references

  1. Zollman S, Godt D, Prive GG, Couderc JL, Laski FA; , Proc Natl Acad Sci U S A 1994;91:10717-10721.: The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. PUBMED:7938017 EPMC:7938017
  2. Bardwell VJ, Treisman R; , Genes Dev 1994;8:1664-1677.: The POZ domain: a conserved protein-protein interaction motif. PUBMED:7958847 EPMC:7958847

Members

This clan contains the following 5 member families:

BACK BTB BTB_2 DUF3342 Skp1_POZ

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
BTB (PF00651) 15670 (58.7%) View
BACK (PF07707) 5713 (21.4%) View
BTB_2 (PF02214) 3855 (14.5%) View
Skp1_POZ (PF03931) 1315 (4.9%) View
DUF3342 (PF11822) 124 (0.5%) View
Total: 5 Total: 26677 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 8 interactions for this clan. More...

Interacting families
A B
Skp1_POZ Skp1
VHL
Skp1_POZ
SOCS_box
BTB BTB
BTB_2 Aldo_ket_red
BTB_2
Shal-type

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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