Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
3964  structures 10099  species 75  interactions 253453  sequences 973  architectures

Clan: TIM_barrel (CL0036)

Summary

Common phosphate binding-site TIM barrel superfamily Add an annotation

This large superfamily of TIM barrel enzymes all contain a common phosphate binding site. The phosphate is found in a variety of cofactors and ligands such as FMN [1,2].

This clan contains 57 families and the total number of domains in the clan is 253453. The clan was built by A Bateman.

Literature references

  1. Copley RR, Bork P; , J Mol Biol 2000;303:627-641.: Homology among (betaalpha)(8) barrels: implications for the evolution of metabolic pathways. PUBMED:11054297 EPMC:11054297
  2. Bork P, Gellerich J, Groth H, Hooft R, Martin F; , Protein Sci 1995;4:268-274.: Divergent evolution of a beta/alpha-barrel subclass: detection of numerous phosphate-binding sites by motif search. PUBMED:7757015 EPMC:7757015

Members

This clan contains the following 57 member families:

Ala_racemase_N ALAD Aldolase AP_endonuc_2 BtpA CdhD CutC DAHP_synth_1 DAHP_synth_2 DeoC DHDPS DHO_dh DHquinase_I DUF1341 DUF2090 DUF556 DUF561 DUF692 DUF993 Dus F_bP_aldolase FMN_dh G3P_antiterm Glu_syn_central Glu_synthase His_biosynth HMGL-like IGPS IMPDH iPGM_N MtrH NanE NAPRTase NeuB NMO OMPdecase Orn_Arg_deC_N Oxidored_FMN PcrB PdxJ PhosphMutase PRAI Pterin_bind QRPTase_C Racemase_4 RhaA Ribul_P_3_epim SOR_SNZ Tagatose_6_P_K ThiG TIM TIM-br_sig_trns TMP-TENI Transaldolase Trp_syntA UvdE UxuA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AP_endonuc_2 (PF01261) 17202 (6.8%) View
Ala_racemase_N (PF01168) 12691 (5.0%) View
HMGL-like (PF00682) 12580 (5.0%) View
Orn_Arg_deC_N (PF02784) 10956 (4.3%) View
Oxidored_FMN (PF00724) 10595 (4.2%) View
DHDPS (PF00701) 10473 (4.1%) View
Dus (PF01207) 9141 (3.6%) View
DAHP_synth_1 (PF00793) 8958 (3.5%) View
Pterin_bind (PF00809) 8265 (3.3%) View
His_biosynth (PF00977) 7930 (3.1%) View
IMPDH (PF00478) 7826 (3.1%) View
DeoC (PF01791) 7750 (3.1%) View
F_bP_aldolase (PF01116) 7516 (3.0%) View
TIM (PF00121) 7470 (2.9%) View
FMN_dh (PF01070) 7189 (2.8%) View
OMPdecase (PF00215) 7126 (2.8%) View
DHO_dh (PF01180) 6787 (2.7%) View
Transaldolase (PF00923) 6718 (2.7%) View
Ribul_P_3_epim (PF00834) 6022 (2.4%) View
NMO (PF03060) 5886 (2.3%) View
TMP-TENI (PF02581) 5722 (2.3%) View
Glu_synthase (PF01645) 5264 (2.1%) View
IGPS (PF00218) 5164 (2.0%) View
NAPRTase (PF04095) 4673 (1.8%) View
Trp_syntA (PF00290) 4254 (1.7%) View
Aldolase (PF01081) 4204 (1.7%) View
ALAD (PF00490) 3912 (1.5%) View
QRPTase_C (PF01729) 3824 (1.5%) View
PRAI (PF00697) 3795 (1.5%) View
continued
Pfam family Num. domains Alignment
Glu_syn_central (PF04898) 3372 (1.3%) View
iPGM_N (PF06415) 2910 (1.1%) View
ThiG (PF05690) 2805 (1.1%) View
NanE (PF04131) 2374 (0.9%) View
CutC (PF03932) 2302 (0.9%) View
DHquinase_I (PF01487) 2260 (0.9%) View
PdxJ (PF03740) 2100 (0.8%) View
SOR_SNZ (PF01680) 1980 (0.8%) View
UxuA (PF03786) 1615 (0.6%) View
NeuB (PF03102) 1576 (0.6%) View
DAHP_synth_2 (PF01474) 1570 (0.6%) View
Tagatose_6_P_K (PF08013) 1086 (0.4%) View
G3P_antiterm (PF04309) 1079 (0.4%) View
RhaA (PF06134) 861 (0.3%) View
DUF692 (PF05114) 833 (0.3%) View
DUF1341 (PF07071) 679 (0.3%) View
PcrB (PF01884) 644 (0.3%) View
BtpA (PF03437) 562 (0.2%) View
PhosphMutase (PF10143) 556 (0.2%) View
UvdE (PF03851) 508 (0.2%) View
DUF2090 (PF09863) 447 (0.2%) View
TIM-br_sig_trns (PF09370) 371 (0.1%) View
CdhD (PF03599) 289 (0.1%) View
DUF993 (PF06187) 227 (0.1%) View
Racemase_4 (PF13615) 179 (0.1%) View
DUF556 (PF04476) 172 (0.1%) View
DUF561 (PF04481) 102 (0.0%) View
MtrH (PF02007) 101 (0.0%) View
Total: 57 Total: 253453 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...