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1502  structures 5612  species 11  interactions 33680  sequences 527  architectures

Clan: Lysozyme (CL0037)

Summary

Lysozyme-like superfamily Add an annotation

Barley chitinase, bacterial chitosanase, and lysozymes from phage and animals all hydrolyse related polysaccharides. The proteins little amino-acid similarity, but have a structurally invariant core consisting of two helices and a three-stranded beta-sheet which form the substrate-binding and catalytic cleft [1].

This clan contains 12 families and the total number of domains in the clan is 33680. The clan was built by A Bateman.

Literature references

  1. Monzingo AF, Marcotte EM, Hart PJ, Robertus JD; , Nat Struct Biol 1996;3:133-140.: Chitinases, chitosanases, and lysozymes can be divided into procaryotic and eucaryotic families sharing a conserved core. PUBMED:8564539 EPMC:8564539

Members

This clan contains the following 12 member families:

Glucosaminidase Glyco_hydro_108 Glyco_hydro_19 Glyco_hydro_46 Lys Lysozyme_like Phage_lysozyme REGB_T4 SLT SLT_2 TraH_2 Transglycosylas

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SLT (PF01464) 14235 (42.3%) View
Glucosaminidase (PF01832) 6435 (19.1%) View
Phage_lysozyme (PF00959) 3255 (9.7%) View
SLT_2 (PF13406) 3080 (9.1%) View
Glyco_hydro_19 (PF00182) 2104 (6.2%) View
Transglycosylas (PF06737) 1273 (3.8%) View
Lysozyme_like (PF13702) 1147 (3.4%) View
Lys (PF00062) 1035 (3.1%) View
Glyco_hydro_108 (PF05838) 820 (2.4%) View
REGB_T4 (PF10715) 136 (0.4%) View
Glyco_hydro_46 (PF01374) 127 (0.4%) View
TraH_2 (PF06871) 33 (0.1%) View
Total: 12 Total: 33680 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 11 interactions for this clan. More...

Interacting families
A B
Lys Lys
Glyco_transf_7C
V-set
Ivy
Glyco_hydro_108 Glyco_hydro_108
PG_binding_3
Glyco_hydro_19 Glyco_hydro_19
Glyco_hydro_46 Glyco_hydro_46
Phage_lysozyme Phage_lysozyme
Gp5_OB
Gp5_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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