Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
272  structures 865  species 10  interactions 5160  sequences 33  architectures

Clan: 4H_Cytokine (CL0053)

Summary

4-helical cytokine superfamily Add an annotation

Cytokines are regulatory peptides that can be produced by various cells for communicating and orchestrating the large multicellular system. Cytokines are key mediators of hematopoiesis, immunity, allergy, inflammation, tissue remodeling, angiogenesis, and embryonic development [2]. This superfamily includes both the long and short chain helical cytokines.

This clan contains 22 families and the total number of domains in the clan is 5160. The clan was built by A Bateman.

Literature references

  1. Hill EE, Morea V, Chothia C; , J Mol Biol 2002;322:205-233.: Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes. PUBMED:12215425 EPMC:12215425
  2. Ouyang S, He F; , J Mol Evol 2003;56:131-136.: Phylogeny of a growth hormone-like cytokine superfamily based upon 3D structure. PUBMED:12574859 EPMC:12574859

Members

This clan contains the following 22 member families:

CNTF EPO_TPO Flt3_lig GM_CSF Hormone_1 IFN-gamma IL10 IL11 IL12 IL13 IL2 IL22 IL3 IL34 IL4 IL5 IL6 Interferon Leptin LIF_OSM PRF SCF

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Hormone_1 (PF00103) 1608 (31.2%) View
Interferon (PF00143) 1000 (19.4%) View
IL10 (PF00726) 341 (6.6%) View
PRF (PF06875) 260 (5.0%) View
IL6 (PF00489) 256 (5.0%) View
IFN-gamma (PF00714) 229 (4.4%) View
Leptin (PF02024) 218 (4.2%) View
IL4 (PF00727) 198 (3.8%) View
IL2 (PF00715) 151 (2.9%) View
SCF (PF02404) 137 (2.7%) View
EPO_TPO (PF00758) 114 (2.2%) View
IL12 (PF03039) 97 (1.9%) View
continued
Pfam family Num. domains Alignment
LIF_OSM (PF01291) 88 (1.7%) View
GM_CSF (PF01109) 64 (1.2%) View
IL5 (PF02025) 60 (1.2%) View
Flt3_lig (PF02947) 56 (1.1%) View
IL11 (PF07400) 55 (1.1%) View
IL22 (PF14565) 53 (1.0%) View
CNTF (PF01110) 48 (0.9%) View
IL13 (PF03487) 47 (0.9%) View
IL3 (PF02059) 41 (0.8%) View
IL34 (PF15036) 39 (0.8%) View
Total: 22 Total: 5160 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 10 interactions for this clan. More...

Interacting families
A B
Flt3_lig Flt3_lig
SCF SCF
IL6 fn3
IL6
Lep_receptor_Ig
EpoR_lig-bind
IFN-gamma IFN-gamma
GM_CSF GM_CSF
Leptin Leptin
IL10 IL10

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...