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2459  structures 7032  species 52  interactions 114169  sequences 2481  architectures

Clan: Glyco_hydro_tim (CL0058)

Summary

Tim barrel glycosyl hydrolase superfamily Add an annotation

This large superfamily contains a range of glycosyl hydrolase enzymes that possess a TIM barrel fold. This CLAN merges clans GH-A, GH-D, GH-H and GH-K from CAZy.

This clan contains 50 families and the total number of domains in the clan is 114169. The clan was built by A Bateman.

Literature references

  1. Naumov DG, Karreras M;, Mol Biol (Mosk). 2009;43:709-721.: [New program PSI protein classifier automatizes the PSI-BLAST results analysis]. PUBMED:19807035 EPMC:19807035

Members

This clan contains the following 50 member families:

Alpha-amylase Alpha_L_fucos Cellulase Cellulase-like DUF187 DUF4015 DUF4038 DUF4434 GHL1-3 GHL12 GHL13 GHL15 GHL5 GHL6 Glyco_hydr_30_2 Glyco_hydro_1 Glyco_hydro_10 Glyco_hydro_101 Glyco_hydro_114 Glyco_hydro_14 Glyco_hydro_17 Glyco_hydro_18 Glyco_hydro_20 Glyco_hydro_25 Glyco_hydro_26 Glyco_hydro_2_C Glyco_hydro_3 Glyco_hydro_30 Glyco_hydro_31 Glyco_hydro_35 Glyco_hydro_39 Glyco_hydro_42 Glyco_hydro_44 Glyco_hydro_53 Glyco_hydro_56 Glyco_hydro_59 Glyco_hydro_66 Glyco_hydro_70 Glyco_hydro_72 Glyco_hydro_77 Glyco_hydro_79n Glyco_hydro_97 Glyco_hydro_cc hDGE_amylase Lipid_bd Melibiase NAGidase NAGLU Raffinose_syn Xylanase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Alpha-amylase (PF00128) 28372 (24.9%) View
Glyco_hydro_1 (PF00232) 11445 (10.0%) View
Glyco_hydro_3 (PF00933) 9251 (8.1%) View
Glyco_hydro_18 (PF00704) 8946 (7.8%) View
Glyco_hydro_2_C (PF02836) 6947 (6.1%) View
Glyco_hydro_31 (PF01055) 5543 (4.9%) View
Cellulase (PF00150) 5309 (4.7%) View
Glyco_hydro_20 (PF00728) 4091 (3.6%) View
Glyco_hydro_25 (PF01183) 3628 (3.2%) View
Glyco_hydro_77 (PF02446) 3053 (2.7%) View
Melibiase (PF02065) 2958 (2.6%) View
Glyco_hydro_10 (PF00331) 2356 (2.1%) View
Glyco_hydro_35 (PF01301) 2284 (2.0%) View
Glyco_hydro_17 (PF00332) 2142 (1.9%) View
Alpha_L_fucos (PF01120) 2021 (1.8%) View
DUF187 (PF02638) 1510 (1.3%) View
Glyco_hydro_42 (PF02449) 1345 (1.2%) View
Glyco_hydro_30 (PF02055) 1151 (1.0%) View
Glyco_hydro_26 (PF02156) 834 (0.7%) View
Glyco_hydro_97 (PF10566) 795 (0.7%) View
Glyco_hydro_72 (PF03198) 708 (0.6%) View
Glyco_hydro_53 (PF07745) 584 (0.5%) View
Raffinose_syn (PF05691) 570 (0.5%) View
Glyco_hydro_14 (PF01373) 548 (0.5%) View
NAGidase (PF07555) 535 (0.5%) View
Glyco_hydro_56 (PF01630) 533 (0.5%) View
continued
Pfam family Num. domains Alignment
Xylanase (PF13201) 518 (0.5%) View
GHL13 (PF14883) 474 (0.4%) View
Glyco_hydro_39 (PF01229) 463 (0.4%) View
Glyco_hydro_101 (PF12905) 455 (0.4%) View
Glyco_hydro_cc (PF11790) 454 (0.4%) View
DUF4434 (PF14488) 420 (0.4%) View
NAGLU (PF05089) 411 (0.4%) View
Glyco_hydro_114 (PF03537) 403 (0.4%) View
DUF4038 (PF13204) 345 (0.3%) View
Cellulase-like (PF12876) 341 (0.3%) View
hDGE_amylase (PF14701) 321 (0.3%) View
DUF4015 (PF13200) 311 (0.3%) View
GHL1-3 (PF11308) 306 (0.3%) View
Glyco_hydro_79n (PF03662) 293 (0.3%) View
Glyco_hydro_70 (PF02324) 260 (0.2%) View
Glyco_hydr_30_2 (PF14587) 205 (0.2%) View
Glyco_hydro_59 (PF02057) 168 (0.1%) View
Glyco_hydro_66 (PF13199) 143 (0.1%) View
GHL12 (PF14882) 137 (0.1%) View
GHL6 (PF14871) 111 (0.1%) View
Glyco_hydro_44 (PF12891) 92 (0.1%) View
GHL5 (PF14872) 27 (0.0%) View
GHL15 (PF14885) 26 (0.0%) View
Lipid_bd (PF12888) 26 (0.0%) View
Total: 50 Total: 114169 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

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Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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