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275  structures 6149  species 4  interactions 42474  sequences 84  architectures

Clan: SIS (CL0067)

Summary

SIS domain fold Add an annotation

This catalytic domain catalyses isomerisation reactions of a variety of sugars [1].

This clan contains 4 families and the total number of domains in the clan is 42474. The clan was built by A Bateman.

Literature references

  1. Bateman A; , Trends Biochem Sci 1999;24:94-95.: The SIS domain: a phosphosugar-binding domain. PUBMED:10203754 EPMC:10203754

Members

This clan contains the following 4 member families:

DUF2529 PGI SIS SIS_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SIS (PF01380) 30074 (70.8%) View
PGI (PF00342) 7325 (17.2%) View
SIS_2 (PF13580) 4732 (11.1%) View
DUF2529 (PF10740) 343 (0.8%) View
Total: 4 Total: 42474 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
SIS GATase_2
SIS
bact-PGI_C
PGI PGI

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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