Sequence alignment for CL0073

PF09287

CEP1_CAEEL/223-418-----------------------EKWMEIDVLK-QKVAKSSD------------------------MAFAIS----SEHE
CEP1_CAEBR/238-432-----------------------EEWLTFEVKK-ERASKVSD------------------------FEFETV----VNDG

PF00870

P53_HUMAN/95-289------------SSVPSQKTYQGSYGFRLGFLH.SGTAKSVT------------------------CTYSPA----LNK-
P53_DANRE/63-257------------STVPETSDYPGDHGFRLRFPQ.SGTAKSVT------------------------CTYSPD----LNK-
Q27937_LOLFO/120-314------------PSVPSNIKYPGEYVFEMSFAQPSKETKSTT------------------------WTYSEK----LDK-
P53_XENLA/69-264------------CAVPSTDDYAGKYGLQLDFQQ.NGTAKSVT------------------------CTYSPE----LNK-
P73_HUMAN/113-309------------PVIPSNTDYPGPHHFEVTFQQ.SSTAKSAT------------------------WTYSPL----LKK-
P53_ORYLA/80-270------------TTVPVTTDYPGSYELELRFQK.SGTAKSVT------------------------STYSET----LNK-
P53_ONCMY/83-278------------STVPTTSDYPGALGFQLRFLQ.SSTAKSVT------------------------CTYSPD----LNK-

PF00554

DIF_DROME/80-251---------------LRIVEEPTSNIIRFRYKCE.GRTAGSI------------------------PGMNSS----SET-
NFKB2_CHICK/39-219---------------LVIIEQPKQRGFRFRYVCE.GPSHGGL------------------------PG.ASS----EKG-
O73789_XENLA/9-174---------------IEIFEQPRQRGMRYRYKCE.GRSAGSI------------------------LG.EQP----LRT-
Q8MV44_AEDAE/135-320---------------LTIVEQPVDK.FRFRYQSEMHGTHGSL------------------------MG.VHT----EKS-
Q962A4_CRAGI/85-252---------------VEIVEQPKQRGLRFRYECE.GRSAGSI------------------------PG.EGS----TSE-
NFKB1_DROME/152-335---------------LRIVEQPVEK.FRFRYKSEMHGTHGSL------------------------NG.ANS----KRT-
Q17034_ANOGA/50-221---------------VEITEQPHPKALRFRYECE.GRSAGSI------------------------PG.VNT----TAE-
TF65_MOUSE/21-186---------------VEIIEQPKQRGMRFRYKCE.GRSAGSI------------------------PG.ERS----TDT-
Q966V6_HALRO/15-183---------------LVITEQPKQRGMRFRYECE.GRSAGSI------------------------PG.ENT----TQE-
NFAC1_PIG/418-578---------------LRIEVQPKSH.HRAHYETE..GSRGAV------------------------KA....----..S-
REL_MOUSE/10-178---------------VEIIEQPRQRGMRFRYKCE.GRSAGSI------------------------PG.ERS----TDN-
Q9GU53_DROME/257-417---------------LEILSQPEQQ.HRARYQTE..GSRGAV------------------------KD....----.RS-
RELB_XENLA/80-248---------------LNITEQPKQRGMRFRYQCE.GRSTGSI------------------------LG.EKS----TEH-
Q9GPE8_TRICA/65-235---------------VKIIEQPASKALRFRYECE.GRSAGSI------------------------PG.ASS----TPE-
O96458_STRPU/62-250---------------LKILEQPRQRGFRFRYGCE.GPSHGGL------------------------PG.QNS----QRG-
Q8K220_MOUSE/102-270---------------LVITEQPKQRGMRFRYECE.GRSAGSI------------------------LG.ESS----TEA-
NFKB1_HUMAN/44-242---------------LQILEQPKQRGFRFRYVCE.GPSHGGL------------------------PG.ASS----EKN-
REL_MELGA/7-175---------------IEIFEQPRQRGMRFRYKCE.GRSAGSI------------------------PG.EHS----TDN-
TF65_CHICK/27-191---------------VEILEQPKQRGMRFRYKCE.GRSAGSI------------------------PG.EHS----TDS-
NFKB2_XENLA/45-226---------------LSIIEQPKQRGFRFRYVCE.GPSHRGL------------------------PG.ASS----EKG-
TF65_XENLA/20-186---------------VEIIEQPKQRGMRFRYKCE.GRSAGSI------------------------PG.ERS----TDT-

PF00853

RUNT_DROME/104-238---------------------------------------------------------------------FAS----LHE-
RUNX2_MOUSE/185-319---------------------------------------------------------------------NRT----MVE-
O76296_HELER/55-189---------------------------------------------------------------------ERS----LVD-
Q9VRA8_DROME/108-242---------------------------------------------------------------------ERT----VDV-
Q9NFP4_CUPSA/20-154---------------------------------------------------------------------ERL----FTD-
LOZEN_DROME/273-407---------------------------------------------------------------------ERL----VQK-

PF02864

O13133_ONCMY/322-575FVVERQRCMPMHPDRPLVIKTGVQFTNKVRLLVKFPELNYQLKIKVIIDKESGDVAAIRG......SRKFNI----LGTN
STAT1_HUMAN/317-567FVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKG......FRKFNI----LGTH
STAT2_PIG/316-566FIVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTAEVSIDRNPPKS...QG......FRKFNI----LTSN
STAT6_HUMAN/273-527FLVEKQP........PQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSV....PQGPGA----GAES
STAT_DROME/342-588FIVDKQP........PQVMKTNTRFAASVRWLIGS.QLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSL----SGQS
STAT4_HUMAN/316-563FVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLS..........NRRFVL----CGTN
STA5A_BOVIN/332-583FIIEKQP........PQVLKTQTKFAATVRLLVGG.KLNVHMNPPQVKATIISEQQAKSL......LKNENT----RNEC
STAT3_HUMAN/321-574FVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRG......SRKFNI----LGTN
O13131_ONCMY/315-562LVVERQPCMPTHPQRPLVLKTQVQFTVKLRFLVKLQEFNYQLKVKALFDKDVTEK...KG......FRKFNI----LGTN

PF00907

TBX6_MOUSE/92-274----------------SLSLENQELWKEFSAVGTEMIITKAG------------------------RRMFPA----CRV-
TBX15_MOUSE/114-305----------------QVELQCADLWKRFHDIGTEMIITKAG------------------------RRMFPA----MRV-
VEGTA_XENLA/49-231----------------GASLEDQDLWSQFHQEGTEMIITKSG------------------------RRMFPQ----CKI-
BRACA_DANRE/36-213----------------KLSLEDAELWTKFKELTNEMIVTKTG------------------------RRMFPV----LRA-
TBX6L_DANRE/35-218----------------HVSLQDRELWDKFSSIGTEMLITKSG------------------------RRMFPS----CKV-
O17212_CAEEL/32-211----------------RVFLQSSNLWRRFHNLGTEMIVTKSG------------------------RRMFPT----LSV-
O62535_DROME/197-386----------------IVVLETKALWDQFHAQGTEMIITKTG------------------------RRMFPT----FQV-
BRAC_HALRO/16-197----------------RLTLNDRALWTKFCSLTNEMIVTKSG------------------------RRMFPV----LKL-
O93389_DANRE/32-214----------------RMTLEDPELWRSFHEIGTEMIITKPG------------------------RRMFPH----CKI-
TBX8_CAEEL/8-196----------------TLREDQDKLWNLFHYHKNEMIVTKSG------------------------RKMFPK----LEY-
BRC2_HALRO/141-324----------------QVQLCDKELWDQFSRAGTEMIVTKTG------------------------RRMFPG----YRI-
TBR1_HUMAN/205-394----------------QVYLCNRPLWLKFHRHQTEMIITKQG------------------------RRMFPF----LSF-
TBX12_CAEEL/78-269----------------ECKLEGSELWAKFFDLGTEMIITKSG------------------------RRMFPT----VKV-
OMB_DROME/329-514----------------KVTLEGKDLWEKFHKLGTEMVITKSG------------------------RQMFPQ----MKF-
BRAC_HEMPU/42-221----------------KVRLDDVELWKKFHKLTNEMIVTKSG------------------------RRMFPV----LSA-
TBX6L_CHICK/28-210----------------TVTLEDMGLWMKFHQIGTEMIITKSG------------------------RRMFPQ----CKI-
TBXT_CHICK/40-217----------------QVVLEDAPLWQRFREVTNEMIVTKNG------------------------RRMFPV----LKI-
BYN_DROME/88-265----------------RISLDDRELWLRFQNLTNEMIVTKNG------------------------RRMFPV----VKI-
H15_DROME/278-473----------------QCHLETKELWDKFHELGTEMIITKSG------------------------RRMFPT----VRV-
TBX11_CAEEL/8-186----------------TLSSTTDPLWRSCHEYDNEMVITVNG------------------------RRIFPT----LEY-
TBX9_CAEEL/7-195----------------SIEGSQETLWKIFHAEVNEMIVTKNG------------------------RKLFPK----LEY-
TBX2_CAEEL/62-244----------------KVELDERELWQQFSQCGTEMVITKSG------------------------RRIFPA----YRV-

PF05224

NDT80_YEAST/105-334----------------EWVGYKRNYFTLVSTFETANCDLDTF------------------------LKSSFDL...LVE.
Q6BNX4_DEBHA/343-545----------------VISCYRRNYIQISMSMNLSGFSNDDD------------------------NNNKVLK...LQT.
RCDK_DICDI/370-549----------------QWIYCRRNHFQLDITAVYPKLFQETQ------------------------YGHNGVT...LSNS
Q6BYS6_DEBHA/185-405----------------TWIGYKRNYFTLVASFSLENFNFDRF------------------------IQNKFYT...YEKS
Q6CEL3_YARLI/159-370----------------SWICYRRNYMSLCAAFDI........------------------------VEHSIVP...MTPP
Q9P619_NEUCS/119-311----------------QWTCYRRNYFSCVCSFSLTPNLPTTE------------------------IQFVQT........
Q6C7W3_YARLI/226-376----------------HLTFYRRNLLQVRASVHN.....DHK------------------------VVYVQT........
Q01652_PENCH/156-329----------------ELTCYRRNLFQITGSVTL.....PRG------------------------MRYIMT........
VIB1_NEUCR/175-340----------------ELTCYRRNLFQISGNICF.....PQI------------------------PLSVML........
Q7S6H5_NEUCR/218-408----------------ELTCYRRNLWQCTGQITL.....PRH------------------------ALHCSLL...LNGN
Q8MQ67_CAEEL/301-451----------------CFVNQKKNHFQVTVKIEAIDPSPPQC------------------------FK............
O60428_HUMAN/20-165----------------AFVCQKKNHFQVTVYIGMLGE..PKY------------------------VK............
Q6NL96_DROME/413-560----------------AYVCQKKNHFQVTCHARLQGD..AKF------------------------VK............
Q74Z59_ASHGO/89-315----------------EWIGYKRNYFTVVSAFDTPHMSLEQF------------------------LQGTYEI...RP..
Q6CIS1_KLULA/102-323----------------DWIGYKRNYFTVVTSFDTPGTDHIEF------------------------MKQAY.........
Q6FKA6_CANGA/110-367----------------DWVGYKRNYFTLVAAFTIDGWDYKKF------------------------LSHSFTIDALPAND

PF09287

CEP1_CAEEL/223-418KYLWTK----MGCLVPIQVKWKLDKRHFNSNLSLRIRFVKYDKKENVEYAIRNPRSDVMK-----CRSH------TEREQ
CEP1_CAEBR/238-432IYLWAK----MKCNIPFIVKWNVSSCH..KQLFLKVRLVNYMASDNIENSIRVP.SNLAK-----CHNH------RMTEE

PF00870

P53_HUMAN/95-289--MFCQ----LAKTCPVQLWVDSTPP---PGTRVRAMAI-YKQSQHMTEVVR-------R-----CPHH------ERCSD
P53_DANRE/63-257--LFCQ----LAKTCPVQMVVDVAPP---QGSVVRATAI-YKKSEHVAEVVR-------R-----CPHH------ERTPD
Q27937_LOLFO/120-314--LYVR----MATTCPVRFKTARPPP---SGCQIRAMPI-YMKPEHVQEVVK-------R-----CPNH------ATAKE
P53_XENLA/69-264--LFCQ----LAKTCPLLVRVESPPP---RGSILRATAV-YKKSEHVAEVVK-------R-----CPHH------ERSVE
P73_HUMAN/113-309--LYCQ----IAKTCPIQIKVSTPPP---PGTAIRAMPV-YKKAEHVTDVVK-------R-----CPNH------ELGRD
P53_ORYLA/80-270--LYCQ----LAKTSPIEVRVSKEPP---KGAILRATAV-YKKTEHVADVVR-------R-----CPHH------QNEDS
P53_ONCMY/83-278--LFCQ----LAKTCPVQIVVDHPPP---PGAVVRALAI-YKKLSDVADVVR-------R-----CPHH------QSTSE

PF00554

DIF_DROME/80-251-----------GKTFPTIEVCNYDG.---PVI.IVVSCVTSDEP.FRQHP....HWLVSKEEADACKSG......IYQKK
NFKB2_CHICK/39-219-----------HKTYPTVKICNYEG.---MAR.IEVDLVTHSDP.PRVHA....HSLVGK...QCNEAG......NCVAI
O73789_XENLA/9-174-----------TGHTHPSRLLIIL..---KRD.SRITLVTKKEP.HKPHP....HDLVGK...D.CRDG......YYELE
Q8MV44_AEDAE/135-320-----------KKTFPTVQLHGFQG.---EAK.IRCSLFQVDPNRRAAHS....HNLVIK.......SGEIDLNDPHDID
Q962A4_CRAGI/85-252-----------KKTFPTIKIHNYTG.---TAV.IVVSCVTKDQP.YEPHP....HNLVGR...D.CKRG......VCTLK
NFKB1_DROME/152-335-----------PKTFPEVTLCNYDG.---PAV.IRCSLFQTNLD..SPHS....HQLVVR......KDD.RDVCDPHDLH
Q17034_ANOGA/50-221-----------QKTFPSIQVHGYRG.---RAV.VVVSCVTKEGPEHKPHP....HNLVGK...EGCKKG......VCTVE
TF65_MOUSE/21-186-----------TKTHPTIKINGYTG.---PGT.VRISLVTKDPP.HRPHP....HELVGK...D.CRDG......YYEAD
Q966V6_HALRO/15-183-----------KKTWPTVQIQNFRG.---DVM.IRVSLVSKDSP.PKPHP....HSLVGK...D.CENG......ICSVR
NFAC1_PIG/418-578-----------AGGHPSVQLHGYVES---EPLTLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAVLSNTKVLEIP
REL_MOUSE/10-178-----------NRTYPSVQIMNYYG.---KGK.IRITLVTKNDP.YKPHP....HDLVGK...D.CRDG......YYEAE
Q9GU53_DROME/257-417-----------GNGFPIVRLTGYD..---KVAVLQVFIGTDIGR.VAPHMFYQACKVAGKNSTQ.CNEKKVDGTMVIEID
RELB_XENLA/80-248-----------NKTLPEIEIINCDGL---EEIHVIVCLVWRDPP.HRVHP....HGLVGK...D.CHNG......ICEVT
Q9GPE8_TRICA/65-235-----------NKTFPSIQVMGYQG.---RAV.VVVSCVTKDEP.FRPHP....HNLVGR...EGCKKG......VCTME
O96458_STRPU/62-250-----------KRSFPSVEICNYKG.---SAR.IVVSLVTNEET.PRPHA....HSLVGK...H.CKDG......LCTVQ
Q8K220_MOUSE/102-270-----------SKTLPAIELRDCGGL---REVEVTACLVWKDWP.HRVHP....HSLVGK...D.CTDG......VCRVR
NFKB1_HUMAN/44-242-----------KKSYPQVKICNYVG.---PAK.VIVQLVTNGKN.IHLHA....HSLVGK...H.CEDG......ICTVT
REL_MELGA/7-175-----------NKTFPSIQILNYFG.---KVK.IRTTLVTKNEP.YKPHP....HDLVGK...D.CRDG......YYEAE
TF65_CHICK/27-191-----------ARTHPTIRVNHYRG.---PGR.VRVSLVTKDPP.HGPHP....HELVGR...H.CQHG......YYEAE
NFKB2_XENLA/45-226-----------KKTFPTVKIFNYVG.---MAR.IEVDLVTHTDP.PRVHA....HSLVGK...HSNKTG......NCIVT
TF65_XENLA/20-186-----------SKTHPTIKINNYQG.---PAR.IRISLVTKDSP.HKPHP....HELVGK...D.CKDG......YYEAE

PF00853

RUNT_DROME/104-238----------MLQEYHGELAQTGSPS-------ILCSALPNHWRSNKSLPGAFKVIALDD-----VPDG-----TLVSIK
RUNX2_MOUSE/185-319----------IIADHPAELVRTDSPN-------FLCSVLPSHWRCNKTLPVAFKVVALGE-----VPDG-----TVVTVM
O76296_HELER/55-189----------ALSEYPGELVKTESPN-------FACSVLPSHWRCNKSLPVAFKVVSLGE-----TKDG-----TMVTIA
Q9VRA8_DROME/108-242----------LLAEHPGELVKTGSPH-------VVCTTLPTHWRSNKTLPIAFKVLALGE-----VMDG-----TIVTIR
Q9NFP4_CUPSA/20-154----------VIDNLPSELVKTGSPC-------FVCSVLPGHWRSNKTLPLPFKVICLGE-----VADG-----TMVTIR
LOZEN_DROME/273-407----------RQQEHPGELVRTSNPY-------FLCSALPAHWRSNKTLPMAFKVVALAE-----VGDG-----TYVTIR

PF02864

O13133_ONCMY/322-575T.KVMN----MEESNNGSLSAEFKHL---TLREQRCGNGGRTNSDASLIVTEELHLITFE--TEVYHQG-----..LKID
STAT1_HUMAN/317-567T.KVMN----MEESTNGSLAAEFRHL---QLKEQKN.AGTRTN.EGPLIVTEELHSLSFE--TQLCQPG-----..LVID
STAT2_PIG/316-566R.KTLT----PEKGQSQGLIWDFGYL---TLMEQRSGGAGKGNNKGPLGVTEELHIISFT--VKYTYQG-----..LKQE
STAT6_HUMAN/273-527TGEIIN----NTVPLENSIPGNCCSA---LFKNLLLKKIKRCERKGTESVTEEKCAVLFS--ASFTLGP-----GKLPIQ
STAT_DROME/342-588SGEIQN----ASSTMEYQQNNHVFSA---SFRNMQLKKIKRAEKKGTESVMDEKFALFFY--TTTTVND-----..FQIR
STAT4_HUMAN/316-563V.KAMS----IEESSNGSLSVEFRHL---QPKEMKSSAGGKGN.EGCHMVTEELHSITFE--TQICLYG-----..LTID
STA5A_BOVIN/332-583SGEILN----NCCVMEYHQATGTLSA---HFRNMSLKRIKRADRRGAESVTEEKFTVLFE--SQFSVGS-----NELVFQ
STAT3_HUMAN/321-574T.KVMN----MEESNNGSLSAEFKHL---TLREQRCGNGGRANCDASLIVTEELHLITFE--TEVYHQG-----..LKID
O13131_ONCMY/315-562T.KVLN----MEES.NGSLAAEFRHL---QLKEQKV.AGNRTN.EGPLIVTEELHCICFE--SELNQSG-----..LELK

PF00907

TBX6_MOUSE/92-274--SVTG....LDPEARYLFLLDVVPV---DGARYR..WQGQHWEPSGKAEPRLP.DRVYI-----HPDS---------PA
TBX15_MOUSE/114-305--KITG....LDPHQQYYIAMDIVPV---DNKRYRYVYHSSKWMVAGNADSPVP.PRVYI-----HPDS---------LA
VEGTA_XENLA/49-231--RLFG....LHPYAKYMLLVDFVPL---DNFRYK..WNKNQWEAAGKAEPHPP.CRTYV-----HPDS---------PA
BRACA_DANRE/36-213--SVTG....LDPNAMYSVLLDFVAA---DNNRWK..YVNGEWVPGGKPEPQSP.SCVYI-----HPDS---------PN
TBX6L_DANRE/35-218--TVTG....LNPKVKYVVIMDMVPF---DNHKYK..WNKDCWEVNGSSDPHLP.NRFFI-----HPDS---------PA
O17212_CAEEL/32-211--IIAG....LDPVKSYVVMVDLECI---EMKRFRYSFHQSKWISTGPGESELP.SRMFV-----HTDS---------PA
O62535_DROME/197-386--RIGG....LDPHATYICMMDFVPM---DDKRYRYAFHNSCWVVAGKADPISP.PRIHV-----HPDS---------PA
BRAC_HALRO/16-197--TASG....LEPNSMYSFLLDFAPA---DSNRWK..YVNGEWVPGGKPEPHAA.SCVYV-----HPDS---------PN
O93389_DANRE/32-214--SLSG....LVPYAKYILLVDMVPE---DGLRYK..WNKDKWEVAGKAEPQPP.YRTYL-----HPDS---------PA
TBX8_CAEEL/8-196--VVRG....LTPNKLYAMMLHIEPS---DDHRYK..FSSGEWVKSGKAEKHRE.PKKLW-----HADG---------VR
BRC2_HALRO/141-324--KISG....LDPTAKYCVMLDIVNV---DDHRYK..FQHGEWTVAGRGEPHLP.QRFFL-----HPNS---------PA
TBR1_HUMAN/205-394--NISG....LDPTAHYNIFVDVILA---DPNHWR..FQGGKWVPCGKADTNVQGNRVYM-----HPDS---------PN
TBX12_CAEEL/78-269--SFTN....VILDALYYIFLDVVPV---DSKRYRYIYNKSAWLTAGKAEPVPK.NRYYL-----HPDS---------PF
OMB_DROME/329-514--RVSG....LDAKAKYILLLDIVAA---DDYRYK..FHNSRWMVAGKADPEMP.KRMYI-----HPDS---------PT
BRAC_HEMPU/42-221--SIAG....LDPNSMYSVLLDFSAA---DDHRWK..YVNGEWIPGGKPDGSPP.TTAYI-----HPDS---------PN
TBX6L_CHICK/28-210--KVSG....LIPYAKYLMLVDFVPV---DNFRYK..WNKDQWEVAGKAEPQLP.CRTYV-----HPDS---------PA
TBXT_CHICK/40-217--SVSG....LDPNAMYSFLLDFAPT---DGHRWK..YVNGEWVPAGKPEPPNH.SCVYI-----HPDS---------PN
BYN_DROME/88-265--SASG....LDPAAMYTVLLEFVQI---DSHRWK..YVNGEWVPGGKAEVPPS.NPIYV-----HPES---------PN
H15_DROME/278-473--SFSGPLRQIQPADRYAVLLDVVPL---DSRRYRYAYHRSSWLVAGKADPPPP.SRIYA-----HPDC---------PL
TBX11_CAEEL/8-186--TVTG....LDTFKLYSMCMHLDLV---DDKKLR..FTGGQWAESVSTEKKDP.PRKVW-----HHNG---------SQ
TBX9_CAEEL/7-195--IVEG....LDENKLYAIMLQLQPV---GESRFK..FSGGKWQETGKAEKQVD.AKKMW-----HADG---------VR
TBX2_CAEEL/62-244--KISG....LDKKSQYFVMMDLVPA---DEHRYK..FNNSRWMIAGKADPEMP.KTLYI-----HPDS---------PS

PF05224

NDT80_YEAST/105-334................DSSVESRLRV---QYFAIKIKA.KNDDD....DTEINLVQ.........HTAK---------RD
Q6BNX4_DEBHA/343-545...............NEYGYSITRVI---KWFKVEIFANTNVSEI..RSIPIVIYD.........DNGQ---------RD
RCDK_DICDI/370-549SSSVD....PTQTPSYMLISGVKTPI---NGLTLTIKGIKNRADMSQQESEVELFQ.........TNSK---------RE
Q6BYS6_DEBHA/185-405S............KNGESVGENKVEI---SYFAIRLVA.KCSDD....DVAISLVQ.........HTAK---------RD
Q6CEL3_YARLI/159-370YPT........GPVYIASGPHENAQC---LYFVLRVEARVCST.....NAPATLMQ.........HTAK---------RD
Q9P619_NEUCS/119-311..................GSPQPYTV---YGFAMSISAAVADSD....NQTIELVQ.........HTPK---------RD
Q6C7W3_YARLI/226-376..................ESGERAKT---QSLWLDVEVTDNSAD....SDPQRLLFCSPKSATSLPADD---------EA
Q01652_PENCH/156-329..................DQGDRIPI---LAQELTVSATESVE.....GNPVKIISVPWKTPSAAAANS---------GP
VIB1_NEUCR/175-340..................ETGETSQI---KNMEVTISAIESVD.....GHPVRLIVIP....WKT....---------..
Q7S6H5_NEUCR/218-408EQ..........QPGGNGAAGRQVRI---KELWASITAMESIE.....GKPTEIISIPWKSNNPAFAAA---------GG
Q8MQ67_CAEEL/301-451..................INGVCKPI---ENFQLSFVGAKSESQ....NSEIPIRQ..........STT---------ER
O60428_HUMAN/20-165..................TPEGLKPL---DCFYLKLHGLEAL......NQSINIEQ..........SQS---------DR
Q6NL96_DROME/413-560..................TPSGFEKI---KSFHLHFYGVKFEAP....NQTIRVEQ..........SQS---------DR
Q74Z59_ASHGO/89-315.................EHSHQRLRV---KYFAVKLVA.KCIED....QSQINLVQ.........HTAK---------RD
Q6CIS1_KLULA/102-323..................HLDNGVEI---KYFATKLAA.KCLED....DKLINLVQ.........HTAK---------RD
Q6FKA6_CANGA/110-367ETVEGSDICFNVRKYSDLHSDRTLPV---EYFAVKIRATDDH......DNDIPLVQ.........HTAK---------RD

PF09287

CEP1_CAEEL/223-418HFP---FD-SFFYIRNSEHEF---S..YSAE---KGSTF-----------------------------TLIMYP------
CEP1_CAEBR/238-432KTP---RE-SFFYVVKSGEHW---TPQINSK---KDQCF-----------------------------VAKLAP------

PF00870

P53_HUMAN/95-289.SDG-.LA-PPQHLIRVEGNL---RVEYLDD---RNTFR-----------------------------HSVVVPYEPPEV
P53_DANRE/63-257GDN.-.LA-PAGHLIRVEGNQ---RANYRED---NITLR-----------------------------HSVFVPYEAPQL
Q27937_LOLFO/120-314HNEK-.HP-APLHIVRCEHK.---LAKYHED---KYSGR-----------------------------QSVLIPHEMPQA
P53_XENLA/69-264PGED-.AA-PPSHLMRVEGNL---QAYYMED---VNSGR-----------------------------HSVCVPYEGPQV
P73_HUMAN/113-309FNEG-QSA-PASHLIRVEGNN---LSQYVDD---PVTGR-----------------------------QSVVVPYEPPQV
P53_ORYLA/80-270....-.VE-HRSHLIRVEGSQ---LAQYFED---PYTKR-----------------------------QSVTVPYEPPQP
P53_ONCMY/83-278NNEG-.PA-PRGHLVRVEGNQ---RSEYMED---GNTLR-----------------------------HSVLVPYEPPQV

PF00554

DIF_DROME/80-251LPPE.ERR.LVLQKVGIQCAK---KLEMRDS---LVERE.............................RRNIDPFN.AKF
NFKB2_CHICK/39-219VGPK.DMT.AQFSNLGVLHVT---KKNMMEI---MKEKLKKQKTRNTNG...................LLTEAELREIEL
O73789_XENLA/9-174FGSD.RTV.LCFQNLGIQCVR---RREVREA---IHARI.............................FAN.EPFG.VRE
Q8MV44_AEDAE/135-320VNEECNYV.AMFQGMGIIHTA---KKNIAEE---LSKKMKKQRSVEMNR...................ELTLREEYQLQK
Q962A4_CRAGI/85-252VKD..TNV.ISFPHLGIQCAK---KKDVENN---LKQRK.............................EINVDPFQ.SGF
NFKB1_DROME/152-335VSKERGYV.AQFINMGIIHTA---KKYIFEE---LCKKKQDRLVFQMNR..................RELSHKQLQELHQ
Q17034_ANOGA/50-221INST.TMS.YTFNNLGIQCVK---KKDVEEA---LRLRQ.............................EIRVDPFR.TGF
TF65_MOUSE/21-186LCPD.RSI.HSFQNLGIQCVK---KRDLEQA---ISQRI.............................QTNNNPFH.VPI
Q966V6_HALRO/15-183VSPETQMT.ACFSNLGIQCVK---RKEVTEA---LMERR.............................RLTVDPFKTVVD
NFAC1_PIG/418-578LLPENNMR.AIIDCAGILKLR---NSDIELR---KG................................ETDIGRKN....
REL_MOUSE/10-178FGPE.RRP.LFFQNLGIRCVK---KKEVKGA---IILRI.............................SAGINPFN.VGE
Q9GU53_DROME/257-417FKPETDMT.ITCDCVGILKER---NVDVEHR---FPEHL.............................AQKNKKKS....
RELB_XENLA/80-248LNPQNGVAKHSFSNLGIQCVR---KREIDSA---VNERL.............................KLNIDPYK...A
Q9GPE8_TRICA/65-235INSD.TMC.VTFSNLGIQCVK---KKDIESA---LRLRE.............................EIKVDPFM.TGF
O96458_STRPU/62-250VGPK.DMT.ASFPNLGILHVT---RKDVVPT---LKTRILAQHRLYKDLINNS..........TPGESHWTEPSDAEIEK
Q8K220_MOUSE/102-270LRPHVSPR.HSFNNLGIQCVR---KKEIEAA---IERKI.............................QLGIDPYN...A
NFKB1_HUMAN/44-242AGPK.DMV.VGFANLGILHVT---KKKVFET---LEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQ
REL_MELGA/7-175FGPE.RRV.LSFQNLGIQCVK---KKDLKES---ISLRI.............................SKKINPFN.VPE
TF65_CHICK/27-191LSPE.RCV.HSFQNLGIQCVK---KRELEAA---VAERI.............................RTNNNPFN.VPM
NFKB2_XENLA/45-226VGPE.DMT.AQFNNLGIVHVT---KKSQTEI---LKEKMKRNILRNTGR..................NTLTEVEERKIEQ
TF65_XENLA/20-186LSPD.RSI.HSFQNLGIQCVK---KREVEDA---VAHRI.............................RTNNNPFN.VSP

PF00853

RUNT_DROME/104-238CGNDENYCGELRNCTTTMKNQ---VAKFNDL---RFVGR-----------------------------SGRGKSF-----
RUNX2_MOUSE/185-319AGNDENYSAELRNASAVMKNQ---VARFNDL---RFVGR-----------------------------SGRGKSF-----
O76296_HELER/55-189AGNDENYCAELKNNTAVMKNQ---VARFNDL---RFVGR-----------------------------SGRGKSF-----
Q9VRA8_DROME/108-242AGNDENFCGELRNCTAVMKNQ---VAKFNDL---RFVGR-----------------------------SGRGKSF-----
Q9NFP4_CUPSA/20-154AGNDENFCGELRNASAVMKNQ---VAKFNDL---RFVGR-----------------------------SGRGKSF-----
LOZEN_DROME/273-407AGNDENCCAELRNFTTQMKND---VAKFNDL---RFVGR-----------------------------SGRGKSF-----

PF02864

O13133_ONCMY/322-575LETHSLPVVVISNICQMPNAW---ASILWYN---MLTNH-----------------------------PKNVNFFTKPPV
STAT1_HUMAN/317-567LETTSLPVVVISNVSQLPSGW---ASILWYN---MLVAE-----------------------------PRNLSFFLTPPC
STAT2_PIG/316-566LTTDTLPVVIISNMNQLSIAW---ASILWFN---LLSSD-----------------------------PQNQQFFSSPPK
STAT6_HUMAN/273-527LQALSLPLVVIVHGNQDNNAK---ATILWDN---AFSEM-----------------------------DR..VPFVVAER
STAT_DROME/342-588VWTLSLPVVVIVHGNQEPQSW---ATITWDN---AFAEI-----------------------------VR..DPFMITDR
STAT4_HUMAN/316-563LETSSLPVVMISNVSQLPNAW---ASIIWYN---VSTND-----------------------------SQNLVFFNNPPP
STA5A_BOVIN/332-583VKTLSLPVVVIVHGSQDHNAT---ATVLWDN---AFAEP-----------------------------GR..VPFAVPDK
STAT3_HUMAN/321-574LETHSLPVVVISNICQMPNAW---ASILWYN---MLTNN-----------------------------PKNVNFFTKPPI
O13131_ONCMY/315-562LETISLPIVVISNVSQLPSGW---ASILWYN---MLTSE-----------------------------PKNLKFFLSPPA

PF00907

TBX6_MOUSE/92-274TGAHWMRQPVSFHRVKLTNST.L.DPHGH.L...ILHSM-----------------------------HKYQPRIHLVRA
TBX15_MOUSE/114-305SGDTWMRQVVSFDKLKLTNNE.L.DDQGH.I...ILHSM-----------------------------HKYQPRVHVIRK
VEGTA_XENLA/49-231PGAHWMKDPICFQKLKLTNNT.L.DQQGH.I...ILHSM-----------------------------HRYKPRFHVVQS
BRACA_DANRE/36-213FGAHWMKAPVSFSKVKLSNKL...NGGGQ.I...MLNSL-----------------------------HKYEPRIHIVKV
TBX6L_DANRE/35-218PGQKWMQYPISFHKLKLTNNT.L.NSNGL.V...VLHSM-----------------------------HKYQPRLHIVQS
O17212_CAEEL/32-211RGAHWMRAPVSFDKMKLTNNQ.L.DNNGH.I...IVNSM-----------------------------HKYRPRVHIIEQ
O62535_DROME/197-386VGSNWMKQIVSFDKLKLTNNQ.L.DENGH.I...ILNSM-----------------------------HRYQPRFHLVYL
BRAC_HALRO/16-197FGSHWMKQPVSFNKVKLTNKG...NGGGQQI...MLNSL-----------------------------HKYEPRIHVVKV
O93389_DANRE/32-214PGSHWMKQPVSFLKLKLTNNA.L.DQHGH.I...ILHSM-----------------------------HRYHPRFHIVQA
TBX8_CAEEL/8-196SGKEWMTNPVCFDRVKITNCA..ESTNASMI...FLHSM-----------------------------HKYTPVMSIYES
BRC2_HALRO/141-324NGSKWMSEIISFHKVKLTNSIGR.DVDGK.I...VLNSM-----------------------------HRYQPRVHIVRT
TBR1_HUMAN/205-394TGAHWMRQEISFGKLKLTNNKGASNNNGQMV...VLQSL-----------------------------HKYQPRLHVVEV
TBX12_CAEEL/78-269TGDQLLKHVISFEKTKLTNNE.V.DKTGH.L...ILNSM-----------------------------HKYQPRIHIVQR
OMB_DROME/329-514TGEQWMQKVVSFHKLKLTNNI.S.DKHGF.VSTTILNSM-----------------------------HKYQPRFHLVRA
BRAC_HEMPU/42-221FGAHWMKQAVNFSKVKLSNKL...NGSGQ.V...MLNSL-----------------------------HKYEPRIHIIRV
TBX6L_CHICK/28-210PGSHWMKEPVSFQKLKLTNNT.L.DQHGH.I...ILHSM-----------------------------HRYKPRFHIVQA
TBXT_CHICK/40-217FGAHWMKAAISFSKVKLTNKL...NGSGQ.I...MLNSL-----------------------------HKYEPQVHIVRV
BYN_DROME/88-265FGAHWMKEPISFAKVKLTNKT...NGNGQ.I...MLNSL-----------------------------HKYEPRVHLVRV
H15_DROME/278-473SPEALRKQVVSFEKVKLTNNE.M.DKSGQ.V...VLNSM-----------------------------HRYQPRIHLVRL
TBX11_CAEEL/8-186TGKDWMLRNVSFDQIRITNRKSKEDGNASYV...HLLTQ-----------------------------HRYIPVLTIYEG
TBX9_CAEEL/7-195KGSDWMWSSICFDRVKISNYS..ESNNASMI...YLNSM-----------------------------HKYIPVLTIYES
TBX2_CAEEL/62-244TGEHWMSKGANFHKLKLTNNI.S.DKHGY.T...ILNSM-----------------------------HKYQPRLHVVRC

PF05224

NDT80_YEAST/105-334KGPQFCPSVCPLVPSPLPKHQ---IIREASN---VRNITKMKKYDSTFYLHRDHVNY....EEYGVDSLLFSYPEDSIQK
Q6BNX4_DEBHA/343-545KERPKDEIVTDENNDFVNPIS---IDKAQST---ITLNESVIKN...............................SEIDN
RCDK_DICDI/370-549KQGEHAPKPVAI.........---.......---..........................................QFGS
Q6BYS6_DEBHA/185-405KGPQFPPPIYPAVPGDLPDHE---TVRASCN---KRNGNKIENMNKVFYFDRAEYYHNTNLDTLKDDSVLKNYPSDSIAR
Q6CEL3_YARLI/159-370PGSQAAPSDTILFPGKLPPHE---FIRDTAN---VRCPKRLEEIFDQVNLTLTEQANLS.KTQVQFLETYPDANKAAISR
Q9P619_NEUCS/119-311KGPVAKPEKVRLLPK..PAQQ---THHPLSG---LYSNPDGSLSSSRAYDH.................QPYGQQQSPLPT
Q6C7W3_YARLI/226-376KAKMVFPDN............---.......---.........................................PTAND
Q01652_PENCH/156-329APEGNNPSTGAKIEKEPPPIP---LDIMAGQ---DLDS.....................................DYATF
VIB1_NEUCR/175-340.PPPNSPEVNQAPDQEPPSLP---LIPWSEE---EEDNGGD..................................HYAIY
Q7S6H5_NEUCR/218-408QQQGQQPEESSRTATTPPKQL---LDLSAGQ---EIDKSG...................................NRVSI
Q8MQ67_CAEEL/301-451KPILHTPVLFKIVE.......---.......---..........................................RRMT
O60428_HUMAN/20-165SKRPFNPVTVNLPP.......---.......---..........................................EQVT
Q6NL96_DROME/413-560SKKAFHPVPIDLQK.......---.......---..........................................HIVS
Q74Z59_ASHGO/89-315KGPQFAPPIHPLVPAPLPNHQ---MIREASN---VRNESKMKKFDHDFFLHRDRILQ.....DFDEGCIIYTYPHDTIKK
Q6CIS1_KLULA/102-323KGPQFAPPIHVIAPANLPKHQ---IIRDASN---VRNESKMKKFDSYFFLHKEDVGT.....GCEVRSVLANYPSDPIKK
Q6FKA6_CANGA/110-367KGPQFSPDICPIIPSPLPNHQ---VIREASN---VRNIVKKQKFDPTFHFYRNKELN.....NYPIDTILGLYPDNCIKK

PF09287

CEP1_CAEEL/223-418GAV---QANFDIIFMCQEKCLDLDDRRKTMCLAVFLDD-------------------------------ENGN-------
CEP1_CAEBR/238-432GTT---QVLFDLIFKCQRSCLDLAERRKRMCLAVFLED-------------------------------ENGN-------

PF00870

P53_HUMAN/95-289GSD---CTTIHYNYMCNSSCMGGMNRRP--ILTIITLE-------------------------------DSSG-------
P53_DANRE/63-257GAE---WTTVLLNYMCNSSCMGGMNRRP--ILTIITLE-------------------------------TQEG-------
Q27937_LOLFO/120-314GSE---WVVNLYQFMCLGSCVGGPNRRP--IQLVFTLE-------------------------------K.DN-------
P53_XENLA/69-264GTE---CTTVLYNYMCNSSCMGGMNRRP--ILTIITLE-------------------------------TPQG-------
P73_HUMAN/113-309GTE---FTTILYNFMCNSSCVGGMNRRP--ILIIITLE-------------------------------MRDG-------
P53_ORYLA/80-270GSE---MTTILLSYMCNSSCMGGMNRRP--ILTILTLE-------------------------------T.EG-------
P53_ONCMY/83-278GSE---CTTVLYNFMCNSSCMGGMNRRP--ILTIITLE-------------------------------TQEG-------

PF00554

DIF_DROME/80-251DHK---DQIDKINRYELRL-----------CYQAFI..-------------------------------.TVG-------
NFKB2_CHICK/39-219EAK---ELKKVMDLSIVRL-----------RFTAYL.R-------------------------------DSSG-------
O73789_XENLA/9-174EQL---LTIEDYDLNVVRL-----------CLQVFL.P-------------------------------DEHG-------
Q8MV44_AEDAE/135-320EAA---EMAKTMNLNQVCL-----------CFQAFQVD-------------------------------ASTG-------
Q962A4_CRAGI/85-252KHL---NKINSIDLNVVRL-----------CFQVFL.P-------------------------------DENG-------
NFKB1_DROME/152-335ETE---REAKDMNLNQVRL-----------CFEAFK.I-------------------------------EDNG-------
Q17034_ANOGA/50-221GHA---KEPGSIDLNAVRL-----------CFQVFLEG-------------------------------QQRG-------
TF65_MOUSE/21-186EEQ---RG..DYDLNAVRL-----------CFQVTV..-------------------------------RDPA-------
Q966V6_HALRO/15-183GDE---RPNVDIDLNIVRL-----------CFEAFC..-------------------------------.FTA-------
NFAC1_PIG/418-578...---........TRVRL-----------VFRVHI..-------------------------------.PQP-------
REL_MOUSE/10-178QQL---LDIEDCDLNVVRC-----------VFMFFL.P-------------------------------DEDG-------
Q9GU53_DROME/257-417...---........TRCRM-----------VFRTQL..-------------------------------.TRD-------
RELB_XENLA/80-248GKW---RLHEEVDLNVVRL-----------CFQASC..-------------------------------.TGP-------
Q9GPE8_TRICA/65-235SHR---NQPTSIDLNAVRL-----------CFQVFLEG-------------------------------ERRG-------
O96458_STRPU/62-250KAK---EMAKDMDLSVVRL-----------CFQTYL.P-------------------------------DISG-------
Q8K220_MOUSE/102-270GSL---KNHQEVDMNVVRI-----------CFQASY..-------------------------------RDQQ-------
NFKB1_HUMAN/44-242AAL---QQTKEMDLSVVRL-----------MFTAFL.P-------------------------------DSTG-------
REL_MELGA/7-175EQL---HNIDEYDLNVVRL-----------CFQAFL.P-------------------------------DEHG-------
TF65_CHICK/27-191EER---GA..EYDLSAVRL-----------CFQVWV..-------------------------------.NGP-------
NFKB2_XENLA/45-226EVK---DLKKVTDLSIVRL-----------KFTAYL.P-------------------------------DSNG-------
TF65_XENLA/20-186EEL---KA..DYDLNTVCL-----------CFQVFI.P-------------------------------DQAA-------

PF00853

RUNT_DROME/104-238------------------------------TLTITI-A-------------------------------TYPV-------
RUNX2_MOUSE/185-319------------------------------TLTITV-F-------------------------------TNPP-------
O76296_HELER/55-189------------------------------TLSIFI-Y-------------------------------TNPP-------
Q9VRA8_DROME/108-242------------------------------TLTIVI-S-------------------------------TNPI-------
Q9NFP4_CUPSA/20-154------------------------------SLTISI-S-------------------------------TSPP-------
LOZEN_DROME/273-407------------------------------TLTITV-A-------------------------------TSPP-------

PF02864

O13133_ONCMY/322-575GTWDQVAEVLSWQFSSTTK..RGLTIEQLTTLAEKLLG-------------------------------PCVN....YSG
STAT1_HUMAN/317-567ARWAQLSEVLSWQFSSVTK..RGLNVDQLNMLGEKLLG-------------------------------PNAS.....PD
STAT2_PIG/316-566APWNLLGPALSWQFSSHVG..QGLNSDQLGMLRDKLFG-------------------------------QNSS....TEG
STAT6_HUMAN/273-527VPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFN-------------------------------DNSLSMEAFQH
STAT_DROME/342-588VTWAQLSVALNIKFGSCTG..RSLTIDNLDFLYEKLQR-------------------------------EERS.......
STAT4_HUMAN/316-563ATLSQLLEVMSWQFSSYVG..RGLNSDQLHMLAEKLTV-------------------------------QSSY.....SD
STA5A_BOVIN/332-583VLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFN-------------------------------SSSSHLEDYNG
STAT3_HUMAN/321-574GTWDQVAEVLSWQFSSTTK..RGLSIEQLTTLAEKLLG-------------------------------PGVN....YSG
O13131_ONCMY/315-562ASWGQLSEVLSWQFSSVTK..RGLNEEQLGMLADKLLG-------------------------------QKAQR...NPE

PF00907

TBX6_MOUSE/92-274..TQLCSQH.......WGG-----------.VASFRFP-------------------------------ETTF-------
TBX15_MOUSE/114-305..DFSSDLSPTKPVPVGDG-----------.VKTFNFP-------------------------------ETVF-------
VEGTA_XENLA/49-231..DDMYNSP.......WGL-----------.VQVFSFP-------------------------------ETEF-------
BRACA_DANRE/36-213..GGI...........QKM-----------.ISSQSFP-------------------------------ETQF-------
TBX6L_DANRE/35-218..PDPCTPH......NPGA-----------.YLRFTFP-------------------------------EAAF-------
O17212_CAEEL/32-211..DDS...........QKR-----------.H.TFSFE-------------------------------ETEF-------
O62535_DROME/197-386..PPKNASLDE..NEHSSH-----------.FRTFIFP-------------------------------ETSF-------
BRAC_HALRO/16-197..GGEAA........SERT-----------.IATFSFP-------------------------------ESQF-------
O93389_DANRE/32-214..DDLYSVR.......WSV-----------.FQTFTFP-------------------------------ETSF-------
TBX8_CAEEL/8-196..PSESPFSVP..QPSTRL-----------.VTSVRLT-------------------------------YTEF-------
BRC2_HALRO/141-324..DDISSVH.......MQR-----------.LCTFAFP-------------------------------QTVF-------
TBR1_HUMAN/205-394..NEDGTEDT...SQP.GR-----------.VQTFTFP-------------------------------ETQF-------
TBX12_CAEEL/78-269..QKANPLDPNKVVMSEEK-----------.HCTYTFP-------------------------------ETQF-------
OMB_DROME/329-514..NDILKLP......Y.ST-----------.FRTYVFK-------------------------------ETEF-------
BRAC_HEMPU/42-221..GGREKQ.........RL-----------.VGSYSFT-------------------------------ETRF-------
TBX6L_CHICK/28-210..DDLFSVR.......WSI-----------.FQVFSFP-------------------------------ETVF-------
TBXT_CHICK/40-217..GGPH...........RM-----------.VMNCSFP-------------------------------ETQF-------
BYN_DROME/88-265..GSE...........QRH-----------.VVTYPFP-------------------------------ETQF-------
H15_DROME/278-473SHGQSIPGSP...KELQDM-----------DHKTFVFP-------------------------------ETVF-------
TBX11_CAEEL/8-186..DQL..............-----------.VHTARIP-------------------------------HSQF-------
TBX9_CAEEL/7-195..PSESPFCVP..QSSNQI-----------.VATAKFP-------------------------------HTEF-------
TBX2_CAEEL/62-244..ADRHNLM......Y.ST-----------.FRTFVFR-------------------------------ETEF-------

PF05224

NDT80_YEAST/105-334VARYERVQFASSISVKKPSQQ.....NKHFSLHVILGAVVDPDTFHGENP..........GIPYDELALKNGS-------
Q6BNX4_DEBHA/343-545YYTVKKLQFKSATPNNGNLTF.....QNYYHLKIKVSAIVADLYYDDY..............IDEDYSSNTYN-------
RCDK_DICDI/370-549LVSIQRLHFRKATLNNARRHGQPNPHQEFNQLVVSLYG.................................RC-------
Q6BYS6_DEBHA/185-405VARFERIQFTSSIRLKSTSVN.....SRYFTLHVELLGIIE............................NEDC-------
Q6CEL3_YARLI/159-370VARFERLQFQFIHRSRREGCK........YRLRVNLMAMIS............................H.NN-------
Q9P619_NEUCS/119-311EHTFERIQFKQATANNGKRRA....AQQYYHLIVELWADVG............................SQGG-------
Q6C7W3_YARLI/226-376EVEWKRLQFKGATAHNGRTKH.....QQFFYVSVKCL................................AELE-------
Q01652_PENCH/156-329PIVWKRLQFRVATANNGRRKE....LQQHFVVRLKVV................................ATLS-------
VIB1_NEUCR/175-340PIGWRRLQFRIATANNGRRKE....LQQHFVLHLKLH................................GTLA-------
Q7S6H5_NEUCR/218-408PVSWKRLQFKHATANNGRRKG....LQQHYVVQINLLAK..............................TAES-------
Q8MQ67_CAEEL/301-451IVTVPRLHFSETTLNNQRKNLRPNPDQKYFNLVVRLYA...............................TATD-------
O60428_HUMAN/20-165KVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVALQA...............................HAQN-------
Q6NL96_DROME/413-560KITVGRLHFSETTNNNMRKKGRPNPEQRFFQLVVGLHV...............................HTIS-------
Q74Z59_ASHGO/89-315VARYERIQFASSITVKKPTQQ.....SKHFVLQLVLGCCIDGNHINRDSN..........SEYYNLDTYDQDA-------
Q6CIS1_KLULA/102-323VARYERIQFASSITLKKTSQQ.....NRRFSLLVVLGCYVKGRHDGIQQS..........SPYHELDHYDEET-------
Q6FKA6_CANGA/110-367VARFERVQFSASNNVDKHFDQ.....NRFFKLHVMFGVAVTESSLINSEFLQSEESKEIFENTSEPFELPNGR-------

PF09287

CEP1_CAEEL/223-418EILHAYIKQVRIVAYPRRDWKNF----CEREDAKQ--
CEP1_CAEBR/238-432ELLHDVIKQLLIVGYPRRDWKNF----CEKRGDFK--

PF00870

P53_HUMAN/95-289NLLGRNSFEVRVCACPGRDRRT--------EEENL--
P53_DANRE/63-257QLLGRRSFEVRVCACPGRDRKT--------EESNF--
Q27937_LOLFO/120-314QVLGRRAVEVRICACPGRDRKA--------DEKAS--
P53_XENLA/69-264LLLGRRCFEVRVCACPGRDRRT--------EEDNY--
P73_HUMAN/113-309QVLGRRSFEGRICACPGRDRKA--------DEDHY--
P53_ORYLA/80-270LVLGRRCFEVRICACPGRDRKT--------EEESR--
P53_ONCMY/83-278QLLGRRSFEVRVCACPGRDRKT--------EEINL--

PF00554

DIF_DROME/80-251---NSKVPLDPIVSSPIYGK-----------------
NFKB2_CHICK/39-219---NFTLALQPVISDPIHDS-----------------
O73789_XENLA/9-174---NYTRALTPVVST.IFDN-----------------
Q8MV44_AEDAE/135-320---RWAQLCEPVYSNPINNM-----------------
Q962A4_CRAGI/85-252---KITRIVPPVVSHCIHDK-----------------
NFKB1_DROME/152-335---AWVPLAPPVYSNAINNR-----------------
Q17034_ANOGA/50-221---RFTEPLTPVVSDIIYDK-----------------
TF65_MOUSE/21-186---GRPLLLTPVLSHPIFDN-----------------
Q966V6_HALRO/15-183---NGRLPLQPVVSNPIFDK-----------------
NFAC1_PIG/418-578---NGRTLSLQVASNPIECS-----------------
REL_MOUSE/10-178---NFTTALPPIVSNPIYDN-----------------
Q9GU53_DROME/257-417---DGTTETLQVCSNPIICT-----------------
RELB_XENLA/80-248---GFKYDIPPVLSDPIYDK-----------------
Q9GPE8_TRICA/65-235---KFTVPLTPVVSEPIYDK-----------------
O96458_STRPU/62-250---HFTRPLDPVISVPVFDS-----------------
Q8K220_MOUSE/102-270---GHLHRMDPILSEPVYDK-----------------
NFKB1_HUMAN/44-242---SFTRRLEPVVSDAIYDS-----------------
REL_MELGA/7-175---NYTLALPPLISNPIYDN-----------------
TF65_CHICK/27-191---GGLCPLPPVLSQPIYDN-----------------
NFKB2_XENLA/45-226---AYTLALPPVISDPIHDS-----------------
TF65_XENLA/20-186---GRMLPLPFVVSQPIYDN-----------------

PF00853

RUNT_DROME/104-238QIASYSKAIKVTVDGPREPR----------SKQSY--
RUNX2_MOUSE/185-319QVATYHRAIKVTVDGPREPR----------RHRQK--
O76296_HELER/55-189QIATYNRAIKVTVDGPREPR----------RPKPK--
Q9VRA8_DROME/108-242QIATYTKAIKVTVDGPREPR----------SKVRH--
Q9NFP4_CUPSA/20-154HVVTYNEAIKVTVDGPREPR----------RQQQQ--
LOZEN_DROME/273-407QVATYAKAIKVTVDGPREPR----------SKTSP--

PF02864

O13133_ONCMY/322-575CQITWAKFCKENMVGKGFSFWVW----LDNIIDLVKK
STAT1_HUMAN/317-567GLIPWTRFCKENINDKNFPFWLW----IESILELIKK
STAT2_PIG/316-566LSLSWVDFIKRESPPGKLPFWTW----LDKILDLVHD
STAT6_HUMAN/273-527RSVSWSQFNKEILLGRGFTFWQW----FDGVLDLTKR
STAT_DROME/342-588EYITWNQFCKEPMPDRSFTFWEW----FFAIMKLTKD
STAT4_HUMAN/316-563GHLTWAKFCKEHLPGKSFTFWTW----LEAILDLIKK
STA5A_BOVIN/332-583MSVSWSQFNRENLPGWNYTFWQW----FDGVMEVLKK
STAT3_HUMAN/321-574CQITWAKFCKENMAGKGFSFWVW----LDNIIDLVKK
O13131_ONCMY/315-562GLIPWTKFCKS.LNEKSFPFWLW----IEAILDLIKR

PF00907

TBX6_MOUSE/92-274--ISVTAYQNPRITQLKIAANPF----AKGFREN---
TBX15_MOUSE/114-305--TTVTAYQNQQITRLKIDRNPF----AKGFRDS---
VEGTA_XENLA/49-231--TSVTAYQNEKITKLKINHNPF----AKGFREQ---
BRACA_DANRE/36-213--IAVTAYQNEEITALKIKHNPF----AKAFLDA---
TBX6L_DANRE/35-218--IAVTAYQNQEITKLKIDNNPF----AKGFRDN---
O17212_CAEEL/32-211--IAVTAYQNHRITSLKIESNPF----AKGFREC---
O62535_DROME/197-386--TAVTAYQNQRVTQLKISSNPF----AKGFRDD---
BRAC_HALRO/16-197--IAVTAYQNEEVTSLKIKHNPF----AKAFLDA---
O93389_DANRE/32-214--TAVTAYQNTKITKLKIDHNPF----AKGFRDE---
TBX8_CAEEL/8-196--IAVTAYQNDAVIKLKIKFNPF----AKGFREG---
BRC2_HALRO/141-324--ITVTAYQNSEVTKLKIDNNPF----AKGFRED---
TBR1_HUMAN/205-394--IAVTAYQNTDITQLKIDHNPF----AKGFRDN---
TBX12_CAEEL/78-269--MAVTAYQNQLITKLKIEKNPF----AKGFRDP---
OMB_DROME/329-514--IAVTAYQNEKITQLKIDNNPF----AKGFRDT---
BRAC_HEMPU/42-221--IAVTAYQNEDITQLKIKYNPF----AKAFLDI---
TBX6L_CHICK/28-210--TSVTAYQNEQITKLKIDNNPF----AKGFREH---
TBXT_CHICK/40-217--IAVTAYQNEEITALKIKYNPF----AKAFLDA---
BYN_DROME/88-265--IAVTAYQNEEVTSLKIKYNPF----AKAFLDA---
H15_DROME/278-473--TAVTAYQNQLITKLKIDSNPF----AKGFRDS---
TBX11_CAEEL/8-186--ISVTAYHKGELNTLKTNNNPY----STGSRKD---
TBX9_CAEEL/7-195--IAVTAYQNQKITDLKIKHNSF----AKGFRDG---
TBX2_CAEEL/62-244--IAVTAYQNEKVTELKIENNPF----AKGFRDA---

PF05224

NDT80_YEAST/105-334--KGMFVYLQEMKTPPLIIRGRS....PSNYASS---
Q6BNX4_DEBHA/343-545--ERNEVSLFELVSEPIIVRGRN....PSFYADR---
RCDK_DICDI/370-549--MGQEYCIVSYVSPALIVRTATQVTPPGDLSPV---
Q6BYS6_DEBHA/185-405--QIQPILLSSIETPPLIIRGRS....PSNYHKD---
Q6CEL3_YARLI/159-370--VHDLIEIASSHTPEIVVRGRS....PASYTES---
Q9P619_NEUCS/119-311--AENYIKVAYRKSAKMIVRGRS....PGHYQNE---
Q6C7W3_YARLI/226-376--NGTKTCLASALSRPVVVRGRN....PRFYLNR---
Q01652_PENCH/156-329--TGAKIPISEVQSGPVIVRGRS....PRNFQSR---
VIB1_NEUCR/175-340--NGTKLVLSELTTAPIVVRGRS....PRNFQAR---
Q7S6H5_NEUCR/218-408--GDKLIKLAEIQSGPVIVRGRS....PRNFDSR---
Q8MQ67_CAEEL/301-451--GT.TVLMQAFASERVIVRATN....PGSFEPP---
O60428_HUMAN/20-165--QNYTLAAQ..ISERIIVRASN....PGQFESD---
Q6NL96_DROME/413-560--GNFPVVSH..GSEKIIVRASN....PGQFESD---
Q74Z59_ASHGO/89-315--DTTFIPILMKQTPALIIRGRS....PSNYPQQ---
Q6CIS1_KLULA/102-323--DMTFVPILMEKTPPLIIRGRS....PSNYCQQ---
Q6FKA6_CANGA/110-367--KYIFLHIEEMETPALIIRGRS....PSNYTPA---

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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