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72  structures 5269  species 7  interactions 10191  sequences 170  architectures

Clan: DNA_ligase (CL0078)

Summary

DNA/RNA ligase superfamily Add an annotation

This superfamily contains both ATP-dependent and NAD dependent DNA ligase enzymes. The family also includes mRNA capping enzymes. The members of this clan were shown to be related by sequence in [1].

This clan contains 4 families and the total number of domains in the clan is 10191. The clan was built by A Bateman.

Literature references

  1. Aravind L, Koonin EV; , J Mol Biol 1999;287:1023-1040.: Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches. PUBMED:10222208 EPMC:10222208

Members

This clan contains the following 4 member families:

DNA_ligase_A_M DNA_ligase_aden mRNA_cap_enzyme RNA_ligase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DNA_ligase_aden (PF01653) 5286 (51.9%) View
DNA_ligase_A_M (PF01068) 3956 (38.8%) View
mRNA_cap_enzyme (PF01331) 521 (5.1%) View
RNA_ligase (PF09414) 428 (4.2%) View
Total: 4 Total: 10191 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 7 interactions for this clan. More...

Interacting families
A B
mRNA_cap_enzyme mRNA_cap_C
DNA_ligase_aden DNA_ligase_aden
DNA_ligase_ZBD
DNA_ligase_OB
RNA_ligase RNA_ligase
DNA_ligase_A_M DNA_ligase_A_N
DNA_ligase_A_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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