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208  structures 842  species 11  interactions 3271  sequences 320  architectures

Clan: ADP-ribosyl (CL0084)

Summary

ADP-ribosylation Superfamily Add an annotation

The members of this clan all represent ADP-ribosylating catalytic domains. The structurally conserved regions are located at the NAD binding region [1]. According to SCOP, the ADP-ribosylation domain is thought to have an "unusual fold".

This clan contains 6 families and the total number of domains in the clan is 3271. The clan was built by RD Finn.

Literature references

  1. Ame JC, Spenlehauer C, de Murcia G; , Bioessays 2004;26:882-893.: The PARP superfamily. PUBMED:15273990 EPMC:15273990

Members

This clan contains the following 6 member families:

ADPrib_exo_Tox ART Diphtheria_C Enterotoxin_a PARP Pertussis_S1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PARP (PF00644) 1951 (59.6%) View
ADPrib_exo_Tox (PF03496) 558 (17.1%) View
ART (PF01129) 454 (13.9%) View
Enterotoxin_a (PF01375) 164 (5.0%) View
Pertussis_S1 (PF02917) 121 (3.7%) View
Diphtheria_C (PF02763) 23 (0.7%) View
Total: 6 Total: 3271 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 11 interactions for this clan. More...

Interacting families
A B
PARP PARP
PARP_reg
ART ART
Pertussis_S1 Pertussis_S2S3
Pertus-S4-tox
Pertus-S5-tox
Diphtheria_C Diphtheria_R
Diphtheria_C
Diphtheria_T
ADPrib_exo_Tox Ras
ADPrib_exo_Tox

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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