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45  structures 1697  species 1  interaction 3343  sequences 14  architectures

Clan: TypeIII_Chap (CL0097)

Summary

Type III secretory system chaperone Add an annotation

The translocation of pathogenic proteins into a host cell is mediated by the type III secretory system. A component of this system is a chaperone, which binds to the protein which is going to be secreted in the bacterial cytosol and is involved in translocation of the secreted protein, although the chaperone is not translocated itself. An individual chaperone associates with one or two specific proteins [1]. There are a large number of type III secretory system chaperones, which are small acidic proteins and exhibit significant sequence divergence. This clan groups type III secretory system chaperones. Members with a known structure form small compact globular domains with an alpha-beta(3)- alpha-beta(2)-alpha like organisation [1].

This clan contains 3 families and the total number of domains in the clan is 3343. The clan was built by RD Finn.

Literature references

  1. Birtalan S, Ghosh P; , Nat Struct Biol 2001;8:974-978.: Structure of the Yersinia type III secretory system chaperone SycE. PUBMED:11685245 EPMC:11685245

Members

This clan contains the following 3 member families:

CesT Chaperone_III YbjN

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
YbjN (PF10722) 1845 (55.2%) View
CesT (PF05932) 1366 (40.9%) View
Chaperone_III (PF07824) 132 (3.9%) View
Total: 3 Total: 3343 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
CesT CesT

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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