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2540  structures 7202  species 33  interactions 60527  sequences 1159  architectures

Clan: Peptidase_PA (CL0124)

Summary

Peptidase clan PA Add an annotation

This clan contains a diverse set of peptidases with the trypsin fold.

This clan contains 24 families and the total number of domains in the clan is 60527. The clan was built by A Bateman.

Members

This clan contains the following 24 member families:

DUF1986 DUF31 DUF316 Peptidase_C24 Peptidase_C3 Peptidase_C30 Peptidase_C37 Peptidase_C3G Peptidase_C4 Peptidase_C62 Peptidase_S29 Peptidase_S3 Peptidase_S30 Peptidase_S31 Peptidase_S32 Peptidase_S39 Peptidase_S46 Peptidase_S55 Peptidase_S6 Peptidase_S7 Peptidase_S76 Pico_P2A Trypsin Trypsin_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Trypsin (PF00089) 22248 (36.8%) View
Trypsin_2 (PF13365) 12156 (20.1%) View
Peptidase_S29 (PF02907) 8309 (13.7%) View
Peptidase_C3 (PF00548) 4118 (6.8%) View
Peptidase_S7 (PF00949) 3378 (5.6%) View
Pico_P2A (PF00947) 2140 (3.5%) View
Peptidase_S30 (PF01577) 1446 (2.4%) View
Peptidase_C4 (PF00863) 1088 (1.8%) View
Peptidase_S6 (PF02395) 1016 (1.7%) View
Peptidase_S3 (PF00944) 862 (1.4%) View
Peptidase_C30 (PF05409) 594 (1.0%) View
Peptidase_S46 (PF10459) 519 (0.9%) View
Peptidase_S55 (PF05580) 510 (0.8%) View
continued
Pfam family Num. domains Alignment
Peptidase_S39 (PF02122) 486 (0.8%) View
Peptidase_C37 (PF05416) 408 (0.7%) View
DUF31 (PF01732) 325 (0.5%) View
Peptidase_S32 (PF05579) 275 (0.5%) View
Peptidase_S31 (PF05578) 226 (0.4%) View
DUF316 (PF03761) 172 (0.3%) View
Peptidase_C24 (PF03510) 118 (0.2%) View
Peptidase_S76 (PF13611) 57 (0.1%) View
DUF1986 (PF09342) 34 (0.1%) View
Peptidase_C3G (PF12381) 29 (0.0%) View
Peptidase_C62 (PF12380) 13 (0.0%) View
Total: 24 Total: 60527 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 33 interactions for this clan. More...

Interacting families
A B
Peptidase_C30 Peptidase_C30
Trypsin EGF
Kunitz_BPTI
PAN_1
Kazal_1
Serpin
Sushi
Trypsin
VWA
WAP
Squash
LRR_1
PDZ
SSI
Sema
TIL
Propep_M14
Staphylokinase
Antistasin
Ecotin
Pacifastin_I
Kazal_2
V-set
Hepsin-SRCR
Peptidase_S7 Kunitz_BPTI
Bowman-Birk_leg
Flavi_DEAD
Peptidase_C3 Peptidase_C3
RdRP_1
Pico_P2A Pico_P2A
Peptidase_S3 Peptidase_S3
Peptidase_S29 Peptidase_S29
Flavi_DEAD

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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