Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
223  structures 4970  species 15  interactions 35661  sequences 1340  architectures

Clan: vWA-like (CL0128)

Summary

von Willebrand factor type A Add an annotation

To add.

This clan contains 16 families and the total number of domains in the clan is 35661. The clan was built by RD Finn.

Literature references

  1. Whittaker CA, Hynes RO; , Mol Biol Cell 2002;13:3369-3387.: Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. PUBMED:12388743 EPMC:12388743

Members

This clan contains the following 16 member families:

CobT_C Copine DUF1194 DUF2201 DUF444 DUF58 Ku_N Med25_VWA Sec23_trunk Ssl1 Tfb4 VWA vWA-TerF-like VWA_2 VWA_3 VWA_CoxE

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
VWA (PF00092) 10632 (29.8%) View
VWA_2 (PF13519) 10039 (28.2%) View
DUF58 (PF01882) 3991 (11.2%) View
VWA_CoxE (PF05762) 2445 (6.9%) View
DUF444 (PF04285) 1564 (4.4%) View
Sec23_trunk (PF04811) 1546 (4.3%) View
VWA_3 (PF13768) 1260 (3.5%) View
Copine (PF07002) 1157 (3.2%) View
Ku_N (PF03731) 702 (2.0%) View
DUF2201 (PF09967) 512 (1.4%) View
CobT_C (PF11775) 462 (1.3%) View
Ssl1 (PF04056) 389 (1.1%) View
Tfb4 (PF03850) 353 (1.0%) View
DUF1194 (PF06707) 226 (0.6%) View
vWA-TerF-like (PF10138) 225 (0.6%) View
Med25_VWA (PF11265) 158 (0.4%) View
Total: 16 Total: 35661 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 15 interactions for this clan. More...

Interacting families
A B
Ku_N SAP
Ku
Ku_C
Sec23_trunk Arf
Gelsolin
Sec23_trunk
Sec23_helical
Sec23_BS
VWA Lectin_C
Sushi
Trypsin
VWA
LRR_1
LRRNT
C1-set

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...