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780  structures 6664  species 12  interactions 120193  sequences 821  architectures

Clan: HAD (CL0137)

Summary

HAD superfamily Add an annotation

This clan represents the haloacid dehalogenase (HAD) superfamily that includes a diverse range of enzymes that use an asp carboxylate as a nucleophile [1].

This clan contains 21 families and the total number of domains in the clan is 120193. The clan was built by A Bateman.

Literature references

  1. Koonin EV, Tatusov RL; , J Mol Biol 1994;244:125-132.: Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search. PUBMED:7966317 EPMC:7966317
  2. Aravind L, Galperin MY, Koonin EV; , Trends Biochem Sci 1998;23:127-129.: The catalytic domain of the P-type ATPase has the haloacid dehalogenase fold. PUBMED:9584613 EPMC:9584613

Members

This clan contains the following 21 member families:

5_nucleotid Acid_phosphat_B Acid_PPase DUF705 HAD HAD_2 Hydrolase Hydrolase_3 Hydrolase_6 Hydrolase_like Hydrolase_like2 LNS2 NIF NT5C PGP_phosphatase PMM PNK3P Put_Phosphatase S6PP Trehalose_PPase UMPH-1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HAD_2 (PF13419) 33740 (28.1%) View
Hydrolase (PF00702) 27368 (22.8%) View
Hydrolase_3 (PF08282) 20961 (17.4%) View
HAD (PF12710) 9618 (8.0%) View
Hydrolase_like (PF13242) 8522 (7.1%) View
Hydrolase_6 (PF13344) 4798 (4.0%) View
NIF (PF03031) 2877 (2.4%) View
Trehalose_PPase (PF02358) 2499 (2.1%) View
Acid_phosphat_B (PF03767) 1773 (1.5%) View
Hydrolase_like2 (PF13246) 1746 (1.5%) View
PNK3P (PF08645) 1136 (0.9%) View
continued
Pfam family Num. domains Alignment
S6PP (PF05116) 845 (0.7%) View
LNS2 (PF08235) 814 (0.7%) View
NT5C (PF06941) 770 (0.6%) View
PMM (PF03332) 691 (0.6%) View
5_nucleotid (PF05761) 680 (0.6%) View
Put_Phosphatase (PF06888) 337 (0.3%) View
Acid_PPase (PF12689) 326 (0.3%) View
PGP_phosphatase (PF09419) 326 (0.3%) View
UMPH-1 (PF05822) 291 (0.2%) View
DUF705 (PF05152) 75 (0.1%) View
Total: 21 Total: 120193 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 12 interactions for this clan. More...

Interacting families
A B
Hydrolase E1-E2_ATPase
Abhydrolase_1
Cation_ATPase_C
Cation_ATPase_N
Hydrolase
PNK3P PNK3P
Hydrolase_3 Hydrolase_3
NT5C NT5C
5_nucleotid 5_nucleotid
UMPH-1 UMPH-1
Acid_phosphat_B Acid_phosphat_B
PMM PMM

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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