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525  structures 9289  species 4  interactions 24271  sequences 39  architectures

Clan: GADPH_aa-bio_dh (CL0139)

Summary

Amino acid biosynthesis and glycosomal dehydrogenase Add an annotation

This clan contains the C terminal domains of dehydrogenase enzymes involved in the biosynthesis of arginine, aspartate and aspartate derived amino acids. It also contains the C terminal domain of GAPDH, a dehydrogenase involved in glycolysis and gluconeogenesis.

This clan contains 2 families and the total number of domains in the clan is 24271. The clan was built by J Mistry.

Literature references

  1. Novotna J, Jandova A, Janouskova M, Laurova L, Skoda V; , Cesk Gynekol 1976;41:733-734.: [Levels of DNA and RNA in the carcinomatous tissue of the collum uteri before and after application of Cytembena (author's transl)]. PUBMED:1036977 EPMC:1036977
  2. Kim H, Feil IK, Verlinde CL, Petra PH, Hol WG; , Biochemistry 1995;34:14975-14986.: Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site. PUBMED:7578111 EPMC:7578111

Members

This clan contains the following 2 member families:

Gp_dh_C Semialdhyde_dhC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Gp_dh_C (PF02800) 15479 (63.8%) View
Semialdhyde_dhC (PF02774) 8792 (36.2%) View
Total: 2 Total: 24271 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
Semialdhyde_dhC Semialdhyde_dh
Semialdhyde_dhC
Gp_dh_C Gp_dh_N
Gp_dh_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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