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49  structures 766  species 4  interactions 6140  sequences 165  architectures

Clan: Golgi-transport (CL0145)

Summary

Golgi-transport Add an annotation

This clan contains families that are involved in intracellular transport and signalling. Arfaptins are proteins which interact with small GTPases involved in vesicular budding at the Golgi complex. They form an elongated dimer of three helix coiled coils and are structurally very similar to the BAR domain [1][2]. The Sec34 family is involved in tethering vesicles to the Golgi [3].

This clan contains 9 families and the total number of domains in the clan is 6140. The clan was built by J Mistry.

Literature references

  1. Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ; , Nature 2001;411:215-219.: The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. PUBMED:11346801 EPMC:11346801
  2. Habermann B; , EMBO Rep 2004;5:250-255.: The BAR-domain family of proteins: a case of bending and binding?. PUBMED:14993925 EPMC:14993925
  3. Whyte JR, Munro S; , Dev Cell 2001;1:527-537.: The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. PUBMED:11703943 EPMC:11703943

Members

This clan contains the following 9 member families:

Arfaptin BAR BAR_2 BAR_3_WASP_bdg FAM92 IMD Pil1 Sec34 Vps5

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
BAR (PF03114) 2173 (35.4%) View
Vps5 (PF09325) 1147 (18.7%) View
BAR_3_WASP_bdg (PF10456) 753 (12.3%) View
IMD (PF08397) 584 (9.5%) View
Arfaptin (PF06456) 535 (8.7%) View
Sec34 (PF04136) 293 (4.8%) View
Pil1 (PF13805) 285 (4.6%) View
BAR_2 (PF10455) 190 (3.1%) View
FAM92 (PF06730) 180 (2.9%) View
Total: 9 Total: 6140 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
IMD IMD
BAR BAR
BAR_3_WASP_bdg PX
BAR_3_WASP_bdg

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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