Sequence alignment for CL0164

PF00431

ENTK_HUMAN/524-631-----CGGPF..ELWEPNTTFSS.TNFPN.--------SYPNLAFCVWILNAQKGKN..IQLHFQE.FDLE.........
ENTK_HUMAN/225-331-----CDGRF..LLTGSSGSFQA.THYPK.--------PSETSVVCQWIIRVNQGLS..IKLSFDD.FNTY.........
C1R_HUMAN/193-302-----CSSE...LYTEASGYISS.LEYPR.--------SYPPDLRCNYSIRVERGLT..LHLKFLEPFDIDDHQQV....
MASP1_HUMAN/185-294-----CSDN...LFTQRTGVITS.PDFPN.--------PYPKSSECLYTIELEEGFM..VNLQFEDIFDIEDHPEV....
TLD_DROME/910-1023-----CGGYL..RATNHSQTFYSHPRYGSR--------PYKRNMYCDWRIQADPESS..VKIRFLH.FEIEYSER.....
NRP1_XENLA/147-262-----CSRN....FTSSNGVIKS.PKYPE.--------KYPNALECTYIIFAPKMQE..IVLEFES.FELEADSNAPGGQ
BMP1_XENLA/398-507-----CGGE....VKKDSGHIQS.PNYPD.--------DYRPNKACVWKLSVSEGFH..VGISFQS.FEIERHDS.....
PSP2_PIG/30-128-----CGRV....IKDTSGSIS.......N--------TDRQKNLCTWTILMKPDQK..VRMAIPY.LNLA.........
ENTK_BOVIN/540-647-----CGGPH..DLWEPNTTFTS.INFPN.--------SYPNQAFCIWNLNAQKGKN..IQLHFQE.FDLEN........
TSG6_HUMAN/135-244-----CGGV....FTDPKQIFKS.PGFPN.--------EYEDNQICYWHIRLKYGQR..IHLSFLD.FDLEDDPG.....
AWN_HORSE/9-107-----CGGV....LRDPPGKIFN.SDGP..--------....QKDCVWTIKVKPHFH..VVIAIPP.LNLS.........
TLD_DROME/797-906-----CKFE....ITTSYGVLQS.PNYPE.--------DYPRNIYCYWHFQTVLGHR..IQLTFHD.FEVESHQE.....
AQN1_PIG/9-107-----CGGV....LRNYSGRIST.YEGPK.--------.....TDCIWTILAKPGSR..VFVAIPY.LNLA.........
C1S_HUMAN/175-287-----CSGD...VFTALIGEIAS.PNYPK.--------PYPENSRCEYQIRLEKGFQVVVTLRRED.FDVEAADSA...G
BMP1_HUMAN/322-431-----CGET....LQDSTGNFSS.PEYPN.--------GYSAHMHCVWRISVTPGEK..IILNFTS.LDLYRSRL.....
BMPH_STRPU/420-529-----CGGH....IERESGTLQS.PNYPD.--------DYHPSKECVWLITMPANYT..VGLSFQS.FEIERHET.....
SPAD1_BOVIN/30-127-----CGGI....LKEESGVIAT.......--------YYGPKTNCVWTIQMPPEYHVRVSIQYLQ.LN...........
TLD_DROME/478-588-----CGGD...LKLTKDQSIDS.PNYPM.--------DYMPDKECVWRITAPDNHQ..VALKFQS.FELEKHDG.....
BMP1_MOUSE/752-861-----CEHK....VTSTSGTITS.PNWPD.--------KYPSKKECTWAISSTPGHR..VKLTFVE.MDIESQPE.....
BP10_PARLI/339-446-----CSER....FTEMTGVITS.PNWPG.--------RYEDNMACVYQIEGPPGST..IELTFTE.MNIENHAA.....
BMP1_HUMAN/435-544-----CGGD....VKKDYGHIQS.PNYPD.--------DYRPSKVCIWRIQVSEGFH..VGLTFQS.FEIERHDS.....
ASTL_COTJA/188-297-----CSTI....IDAAFGSLKS.ANYPR.--------NYSDNTNCVWLIRTRSRK...ISLHFRD.FDLRRTRG.....
BMP1_MOUSE/865-978-----CGGQVRADVKTKDLYSHA.QFGDN.--------NYPGGVDCEWVIVAEEGYG..VELVFQT.FEVEEETD.....
TLD_DROME/634-750-----CGGVV..DATKSNGSLYS.PSYPD.--------VYPNSKQCVWEVVAPPNHA..VFLNFSH.FDLEGTRFHY..T
FBP1_STRPU/62-173-----CGYN....VFDANGMIDS.PNYPA.--------MYNNRADCLYLVRITKARS..ITFTIED.FMTE.........
BMP1_HUMAN/591-700-----CGGF....LTKLNGSITS.PGWPK.--------EYPPNKNCIWQLVAPTQYR..ISLQFDF.FETEGNDV.....
NRP1_XENLA/27-138-----CGDT...IKITSPSYLTS.AGYPH.--------SYPPSQRCEWLIQAPEHYQ.RIMINFNPHFDLEDRE......
BMPH_STRPU/307-416-----CGRT....LLESTGNFSS.PEWPG.--------QYDGDQTCVWRISVTPGET..ISLQFTG.FELVGSDG.....
SPAN_STRPU/340-447-----CSYR....FTEMTGEITS.PNYPS.--------NYEDNTACVYEIEGPYGST..IELTFLD.MEIETETL.....

PF02408

Q9XUH2_CAEEL/18-132NV...CKNGNV..INKR.LNGLPF.YWPPTWNESQAAPFLEQGQLCSWTVTIPQGYY--AKLIISGETLD..--------
O02355_CAEEL/19-134ENSFVCPSNFIT.AESGPIGVIP...YGRV.....GLSVIPALYDCAYNFYVYPGWA--LHFSISTHYDQL.--------
Q19223_CAEEL/14-133SNALDC.......TQIPAGGIVPR.HNATIPAGAKEPVLIPPNFNCLYNIKVPAMVY--ARVVLENGLNG..--------
Q9XUH7_CAEEL/19-137AVGNTCKTGNV..VHKPVIDGTPV.YFPATWREDKAAPALAKDQSCSWMVTIPQGYY--AKLTISGKMGD..--------
O45988_CAEEL/18-136AEGPQC.NGTLT.FDKPQNGATI...YPEDFSDS.NPPLFPDNCACEYQVNVPENWY--ASVKLFVKPGVT.--------
O17945_CAEEL/15-132VFSLECKTGNV..INKP.LDDSPV.IWPATWDPRVAAPQLDKGQTCSWTVTIPDGFY--AKLVISAKAMD..--------
Q9XUA8_CAEEL/21-138LADYTC.SPSIT.INPPVNISNAW.FYPNTWNDSLPAPTYAAGQNCSWIINIPKGMY--AWVSVNASTNT..--------
O17949_CAEEL/22-142QIQCPS.FNSTI.TPDLALPSNTY.YYPYPFDQNSTISSYTPNQFCKFIVEIPKLQY--AYFTMMADIND..--------
O02357_CAEEL/17-127AAQFSCPLNTIS.KNNGMSGSIP........PGAASMVQVPAGSTCTFKFDIPKGFA--LKIETTA......--------
Q20747_CAEEL/18-132QIGAQCQSRTVN.VTS.IQGTIP...YPSV.....NLVKIDQWESCYYNFIIPLGYA--LQFQISYTMDK..--------
O02358_CAEEL/18-128AAQFSCPTTHIT.KDNGIFGAIP........TGAASMVTVPAGVDCTYFFDIPKGFA--VKLETTA......--------
Q9XUA9_CAEEL/22-139ADYYTC.SPSIT.INPPANISNAW.FYPNGWNATLPDPGYAAGQNCSWIINVPKGMF--ASLNVEASTDP..--------
Q9XUH3_CAEEL/16-137VNCYECMNNTVV.INAPSDISKPV.FYPDGWDGQSSTPQISENQQCVMTINVPTGYY--ATVTFYKHFT...--------
Q9XUE0_CAEEL/15-132ASASVCKTGNL..INKP.VNDSPV.IWPATWDMKFAPPKLDKGQTCSWTVTVPDGFY--AKLVISAKAMD..--------
O17948_CAEEL/18-138ANAFDCQAGH...FNAPVDTSTTT.WYPLNFNET.EPPLFPNNFNCLFNIMVPVGWS--AVVRLTMNMTIPS--------
Q9XUH8_CAEEL/17-134AAQNTCNTQST..INRP.VNGQPV.YWPATWRENQTAPALAEDQSCSWIVTIPEGYY--ARLIINGKMGD..--------
Q21330_CAEEL/17-134ADGYTC..ANIM.RNPTQNLSEPY.YYPETWRENMEPTKYAPNQICNWQINVPEGLY--ATVIFYKKTDS..--------
O45077_CAEEL/17-136TAALDC.......TQIPNNAIIPL.SYTTIPAGATGLVEIPPNFNCVYNVKVPKMVY--ARVRLENGLKG..--------
Q21327_CAEEL/26-144ADGYTC.AGNTL.INPFLNLSEPY.YYPGTWRENMEPAEYAPDQKCNWKINVPQGTY--ATVIFYKKTQY..--------
Q9U3N6_CAEEL/16-138VASFNC.NGTTT.IEAPSAPSNTT.FYPRGWTGKGLTPRALPNQVCFFTVNVPKGYF--ATVTFNKRFNS..--------
Q93765_CAEEL/17-127ADDLTC.......PNSPITSNVPSGHFPLN.....GLAKFPANYDCSVEFEIPDGQV--IKFIVQTDALFE.--------
Q21329_CAEEL/17-135SSGYQC.QGPIK.ISPPDDLTRTV.YWPSIWNDSMPPIPIATQQNCKWEIAVPDGLY--ATAVFYKNAKN..--------
O45754_CAEEL/17-137ATIPECSGGVVT.FDKPANTTIGT.SYPGVFNNS.NIQNFPKLYNCDYQINVPQNYS--ARVHLYVVTNDN.--------
O17947_CAEEL/45-162LVGRSCLEKQVVEPKKPVNSSEEF.EFPNN.....KSVVFLANKSCSWVILVPGNFF--VILYINATVPP..--------

PF00431

ENTK_HUMAN/524-631.NINDVVEIRDGEEAD.SLLLAVYTG.....PGPVKDVFSTTNRMTVLLIT.NDVLA----RGGFKANF----
ENTK_HUMAN/225-331..YTDILDIYEGVGSS.KILRASIW......ETNPGTIRIFSNQVTATFLIESDESD----YVGFNATY----
C1R_HUMAN/193-302HCPYDQLQIYANGK.....NIGEFCG.....KQRPPDLDTSSNAVDLLFFT.DESGD----SRGWKLRY----
MASP1_HUMAN/185-294PCPYDYIKIKVGPK.....VLGPFCG.....EKAPEPISTQSHSVLILFHS.DNSGE----NRGWRLSY----
TLD_DROME/910-1023.CDYDYLEITEEGYSM.NTIHGRFCG.....KHKPPIIISNSDTLLLRFQT.DESNS----LRGFAISF----
NRP1_XENLA/147-262TCRYDWLGIWDGFPGV.GPHIGRYCG.....QNTPGRVRSFTGILSMIFHT.DSAIA----KEGFFANF----
BMP1_XENLA/398-507.CAYDYLEIRDGSSET.SPLVGRFCG.....YDKPDDIKSSTNQLWIKFVS.DGSIN----KAGFSLNY----
PSP2_PIG/30-128.CGKEYVEVFDGLLSG..PSYGKLC......AGAAIVFLSTANTMTIKYNR.ISGNS----SSPFLIYF----
ENTK_BOVIN/540-647..IADVVEIRDGEGDD.SLFLAVYTG.....PGPVNDVFSTTNRMTVLFIT.DNMLA----KQGFKANF----
TSG6_HUMAN/135-244.CLADYVEIYDSYDDV.HGFVGRYCG.....DELPDDIISTGNVMTLKFLS.DASVT----AGGFQIKY----
AWN_HORSE/9-107.CGKEYVELLDGPPGS..EIIGKICG......GISLVFRSSSNIATIKYLR.TSGQR----ASPFHIYY----
TLD_DROME/797-906.CIYDYVAIYDGRSEN.SSTLGIYCG....GREPYAVIAS.TNEMFMVLAT.DAGLQ----RKGFKATF----
AQN1_PIG/9-107.CGKEYVEVQDGLPGA..GNYGKLC......SGIGLTYQSSSNALSIKYSR.TAGHS----ASSFDIYY----
C1S_HUMAN/175-287NC.LDSLVFVAGDR.....QFGPYCGH...GFPGPLNIETKSNALDIIFQT.DLTGQ----KKGWKLRY----
BMP1_HUMAN/322-431.CWYDYVEVRDGFWRK.APLRGRFCG.....SKLPEPIVSTDSRLWVEFRS.SSNWV----GKGFFAVY----
BMPH_STRPU/420-529.CIYDYVEVRDGHEDT.SPLIGRYCG.....YFIPDDIKSTGNKMMVTFVS.DGSVN----KGGFSADF----
SPAD1_BOVIN/30-127.CNKESLEIIDGLPGS..PVLGKIC......EGSLMDYRSSGSIMTVKYIR..EPEH----PASFYEVL----
TLD_DROME/478-588.CAYDFVEIRDGNHSD.SRLIGRFCG.....DKLPPNIKTRSNQMYIRFVS.DSSVQ----KLGFSAAL----
BMP1_MOUSE/752-861.CAYDHLEVFDGRD.AKAPVLGRFCG.....SKKPEPVLATGNRMFLRFYS.DNSVQ----RKGFQASH----
BP10_PARLI/339-446.CRYDAVEVRKDDINS...DGEKFCG....NTLPAVQISS.GNQMLISFTS.DPSIT----GRGFRATY----
BMP1_HUMAN/435-544.CAYDYLEVRDGHSES.STLIGRYCG.....YEKPDDIKSTSSRLWLKFVS.DGSIN----KAGFAVNF----
ASTL_COTJA/188-297.CQGDYVKVYDGSSKYSPVLMNKTCG.....SQIPTDVVSSSSLMLIEFVT.DGRDT----ASGFQATF----
BMP1_MOUSE/865-978.CGYDYIELFDGYDST.APRLGRYCG.....SGPPEEVYSAGDSVLVKFHS.DDTIS----KKGFHLRY----
TLD_DROME/634-750KCNYDYLIIYSKMRDNRLKKIGIYCG.....HELPPVVNSEQSILRLEFYS.DRTVQ----RSGFVAKF----
FBP1_STRPU/62-173.VFKDVVEYGIGPEADFNQALGSFEGNLTQDDVIPAPFTVQGDQAWFIFST.DRNIV----NRGFRITF----
BMP1_HUMAN/591-700.CKYDFVEVRSGLTAD.SKLHGKFCG.....SEKPEVITSQYNNMRVEFKS.DNTVS----KKGFKAHF----
NRP1_XENLA/27-138.CKYDYVEVIDGDNAN.GQLLGKYCG.....KIAPSPLVSTGPSIFIRFVS.DYETP----GAGFSIRY----
BMPH_STRPU/307-416.CWYNYLEVRDGHWRH.SPLLGRFCG.....ASLPDPILSSDSRLWIELKS.SAHRY----SRGFAANY----
SPAN_STRPU/340-447.CRYDAVEVRKDDINS...IGEKFCG....NTLPPVQISS.SNQMMVSFTS.DPSIT----RRGFKATY----

PF02408

Q9XUH2_CAEEL/18-132-.LDSYFQTIDSAGNL-...ARTTHE-----GLEPY..YFVSPKFQLVVSN-DSPA.....TFAFKIIWLPLP
O02355_CAEEL/19-134-.LGDNITFTDSLGVV-..HILITPN-----QHIDQ..WSSAPSAILHINT-ISNTS....QMFAIYEFVNIA
Q19223_CAEEL/14-133-.NNDQITVTNEQNAK-....TFINS-----RSGKYATFYVFPNTLTSFLV-STKSVNMHSSFRMVVDYYSLN
Q9XUH7_CAEEL/19-137-.KHSYFQTVDCTGNV-...VQTKLE-----TKHPY..YFPSPKFTLVVSN-EAAA.....TFAFKIEWAPYT
O45988_CAEEL/18-136-EQIAPVEVWDQLQKR-...EQVFSS-----YNELF..YFISNGGHITLST-KTAKV....HFGFVVNWYQYN
O17945_CAEEL/15-132-.RDTYFQTIDSAGNM-...AKTAVE-----KKEPY..YFVKPKFTIAVSN-NAPT.....SFGFQINWLPFP
Q9XUA8_CAEEL/21-138-..QSSLTLVDSVSYS-...TRIEDA-----GLEPF..FLLDPSFTVTLQA-VQMG.....TFGIRVQWYNVR
O17949_CAEEL/22-142-..DSMLTITDCNGKS-...EIVMTS-----EFQPY..VFVGGQFSISLLV-GTNGNN..TRFAFQVQWSDFP
O02357_CAEEL/17-127-..DYDISKRDSIKFD-...DFYITS-----PAEKKIEYAVRKTLPYNVVS-KSGSL....KFFATYTYVDIS
Q20747_CAEEL/18-132-..GDVLTITNSLGVT-VGFTNFTGV-----QKDVY..WCTAGDSTLRVTS-FSGNL....AFLISYQFYSLK
O02358_CAEEL/18-128-..LYDVSPGDSIRFD-...YFYISS-----PAEKRIEFAVNQTLPFHVVS-VTGNL....QFFATYTYIDMT
Q9XUA9_CAEEL/22-139-..QSSLIVTDSVNYS-...TKITSS-----DLEPF..YLMDPSFTITLQA-NQVG.....TFAMRVYWREIP
Q9XUH3_CAEEL/16-137-..EPGGYLYFPSRKI-...ELLQND-----DYNPY..IFPSPMVKINIGT-DNRNDV.MNQFGFKVVYSKYP
Q9XUE0_CAEEL/15-132-.RDTYFQTIDSAGNL-...AKTGNE-----KMKPY..YFVGPKFTIALSS-NAPA.....AFGFKIIWLPFP
O17948_CAEEL/18-138-DFAVSVRGFDNYGNS-...DAVYTA-----TNEHF..YFISNGGSIQLNT-RQQNV....RFGFNLRYYKSA
Q9XUH8_CAEEL/17-134-.PYSHFLTIDSAGNL-...ITSSHE-----TMQPY..FFPPSKFTLSLSN-DEVA.....AFAFKIEWSPFN
Q21330_CAEEL/17-134-..ESGIKCTYPNGEQ-...VYIEDN-----DQNPY..KFTYPRFQIDLQV-GDKQG....EFSFKVVWSEYP
O45077_CAEEL/17-136-.YNDLITVQDQQGTY-....TRVSS-----RSPSVLNFYVFPNTTTTFQV-VTKSVDMHSSFRMIVFYQPMY
Q21327_CAEEL/26-144-..ESGIKCAYPGKDL-...EYISDN-----DQNPY..IFTSPQFQVDLKV-GDKPG....EFSFKVVWSKYP
Q9U3N6_CAEEL/16-138-..TLGAYMVYSNHKM-...MMLNDN-----DRNPF..IFTHPKFQINLAI-GNSTTTPDTTFGFKVVWSKFP
Q93765_CAEEL/17-127-.NLDSFVIRDSRSTL-....YKMDV-----GESVF..FAAANNSKVYIST-NSGKA....SFYFSWQYIDVS
Q21329_CAEEL/17-135-..NVAIAVGYPNGLQ-...EGLDNM-----DYNPY..IFTSPQFLINLYK-SAGDG....SFSFKVTWSKYP
O45754_CAEEL/17-137-.TTAPVQVTDQLGRS-...EEVQSV-----KNTLF..FFISPGGKIQLST-GNREV....GFGFVIYWDEYP
O17947_CAEEL/45-162-..AGRIRATQAPNHT-...ESFTDT-----HVEVA.LLFVAPSFELNWFS-GNSSS...GGINFSVQWQPFT

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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