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2327  structures 7198  species 29  interactions 142836  sequences 1079  architectures

Clan: Thioredoxin (CL0172)

Summary

Thioredoxin-like Add an annotation

This clan contains families related to the thioredoxin family. Thioredoxins are small enzymes that are involved in redox reactions via the reversible oxidation of an active centre disulfide bond. The thioredoxin fold consists of a 3 layer alpha/beta/alpha sandwich and a central beta sheet.

This clan contains 45 families and the total number of domains in the clan is 142836. The clan was built by J Mistry.

Literature references

  1. Qi Y, Grishin NV; , Proteins 2005;58:376-388.: Structural classification of thioredoxin-like fold proteins. PUBMED:15558583 EPMC:15558583

Members

This clan contains the following 45 member families:

2Fe-2S_thioredx AhpC-TSA AhpC-TSA_2 ArsC ArsD Calsequestrin DIM1 DSBA DUF1525 DUF1687 DUF2703 DUF4174 DUF836 DUF899 DUF953 ERp29_N Glutaredoxin GSHPx GST_N GST_N_2 GST_N_3 HyaE KaiB MRP-S23 MRP-S25 OST3_OST6 Phosducin Redoxin SCO1-SenC SelP_N SH3BGR T4_deiodinase Thioredox_DsbH Thioredoxin Thioredoxin_2 Thioredoxin_3 Thioredoxin_4 Thioredoxin_5 Thioredoxin_6 Thioredoxin_7 Thioredoxin_8 Thioredoxin_9 Tom37 TraF YtfJ_HI0045

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Thioredoxin (PF00085) 24231 (17.0%) View
AhpC-TSA (PF00578) 16547 (11.6%) View
GST_N_3 (PF13417) 16191 (11.3%) View
Glutaredoxin (PF00462) 11246 (7.9%) View
Redoxin (PF08534) 9684 (6.8%) View
ArsC (PF03960) 7591 (5.3%) View
GST_N (PF02798) 5748 (4.0%) View
DSBA (PF01323) 5572 (3.9%) View
GSHPx (PF00255) 4817 (3.4%) View
2Fe-2S_thioredx (PF01257) 4533 (3.2%) View
Thioredoxin_4 (PF13462) 3857 (2.7%) View
GST_N_2 (PF13409) 3673 (2.6%) View
Thioredoxin_2 (PF13098) 3289 (2.3%) View
Thioredoxin_7 (PF13899) 3155 (2.2%) View
SCO1-SenC (PF02630) 2856 (2.0%) View
Thioredoxin_3 (PF13192) 2658 (1.9%) View
Thioredoxin_8 (PF13905) 2061 (1.4%) View
Thioredoxin_6 (PF13848) 1636 (1.1%) View
DUF836 (PF05768) 1303 (0.9%) View
Thioredox_DsbH (PF03190) 1287 (0.9%) View
Phosducin (PF02114) 1240 (0.9%) View
YtfJ_HI0045 (PF09695) 1008 (0.7%) View
Thioredoxin_5 (PF13743) 777 (0.5%) View
continued
Pfam family Num. domains Alignment
TraF (PF13728) 761 (0.5%) View
OST3_OST6 (PF04756) 672 (0.5%) View
HyaE (PF07449) 623 (0.4%) View
Thioredoxin_9 (PF14595) 573 (0.4%) View
AhpC-TSA_2 (PF13911) 573 (0.4%) View
DUF899 (PF05988) 520 (0.4%) View
DUF4174 (PF13778) 508 (0.4%) View
DIM1 (PF02966) 463 (0.3%) View
ArsD (PF06953) 439 (0.3%) View
SH3BGR (PF04908) 396 (0.3%) View
KaiB (PF07689) 352 (0.2%) View
T4_deiodinase (PF00837) 345 (0.2%) View
Tom37 (PF10568) 336 (0.2%) View
DUF953 (PF06110) 278 (0.2%) View
DUF1525 (PF07511) 218 (0.2%) View
Calsequestrin (PF01216) 208 (0.1%) View
MRP-S25 (PF13741) 140 (0.1%) View
DUF1687 (PF07955) 121 (0.1%) View
MRP-S23 (PF10484) 115 (0.1%) View
ERp29_N (PF07912) 92 (0.1%) View
SelP_N (PF04592) 83 (0.1%) View
DUF2703 (PF10865) 60 (0.0%) View
Total: 45 Total: 142836 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

We could not retrieve a family relationship diagram for this clan.

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 29 interactions for this clan. More...

Interacting families
A B
Thioredoxin Thioredoxin
Tubulin
Kunitz_legume
LMWPc
PAPS_reduct
FeThRed_A
FeThRed_B
DsbC
GST_N GST_C
GST_N
Glutaredoxin2_C
Glutaredoxin GST_C
Glutaredoxin
Redoxin
DSBA DSBA
DsbB
GSHPx GSHPx
ERp29_N ERp29
ERp29_N
AhpC-TSA AhpC-TSA
1-cysPrx_C
Redoxin Glutaredoxin
Redoxin
KaiB KaiB
HyaE HyaE
DIM1 GYF
ArsC RNA_pol_A_CTD
SH3BGR SH3BGR
Phosducin WD40

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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