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149  structures 2803  species 2  interactions 12513  sequences 389  architectures

Clan: TRASH (CL0175)

Summary

TRASH superfamily Add an annotation

TRASH-like domains contain well-conserved cysteine residues that are thought to be involved in metal coordination. These domains are thus expected to be involved in metal trafficking and heavy-metal resistance. It has been suggested that the members adopt a 'treble-clef' fold, with 3/4 beta strands preceding a C-terminal alpha helix [1].

This clan contains 11 families and the total number of domains in the clan is 12513. The clan was built by M Fenech.

Literature references

  1. Ettema TJ, Huynen MA, de Vos WM, van der Oost J; , Trends Biochem Sci 2003;28:170-173.: TRASH: a novel metal-binding domain predicted to be involved in heavy-metal sensing, trafficking and resistance. PUBMED:12713899 EPMC:12713899

Members

This clan contains the following 11 member families:

Arc_trans_TRASH ATPase-cat_bd DUF2256 DUF329 DUF581 Ribosomal_L24e YHS zf-FCS zf-HIT zf-Mss51 zf-MYND

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-MYND (PF01753) 3934 (31.4%) View
zf-FCS (PF06467) 1780 (14.2%) View
YHS (PF04945) 1534 (12.3%) View
DUF329 (PF03884) 1426 (11.4%) View
zf-HIT (PF04438) 1073 (8.6%) View
Ribosomal_L24e (PF01246) 1060 (8.5%) View
ATPase-cat_bd (PF12156) 725 (5.8%) View
DUF581 (PF04570) 427 (3.4%) View
DUF2256 (PF10013) 341 (2.7%) View
zf-Mss51 (PF13824) 148 (1.2%) View
Arc_trans_TRASH (PF08394) 65 (0.5%) View
Total: 11 Total: 12513 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
YHS Phenol_Hydrox
TmoB

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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