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311  structures 5998  species 3  interactions 88093  sequences 6949  architectures

Clan: PAS_Fold (CL0183)

Summary

PAS domain clan Add an annotation

This clan contains PAS domains that are found in a wide variety of bacterial signaling proteins.

This clan contains 13 families and the total number of domains in the clan is 88093. The clan was built by A Bateman.

Literature references

  1. Zhulin IB, Taylor BL, Dixon R; , Trends Biochem Sci 1997;22:331-333.: PAS domain S-boxes in archaea, bacteria and sensors for oxygen and redox. PUBMED:9301332 EPMC:9301332
  2. Borgstahl GE, Williams DR, Getzoff ED; , Biochemistry 1995;34:6278-6287.: 1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore. PUBMED:7756254 EPMC:7756254
  3. Ponting CP, Aravind L; , Curr Biol 1997;7:674-677.: PAS: a multifunctional domain family comes to light. PUBMED:9382818 EPMC:9382818
  4. Hefti MH, Francoijs KJ, de Vries SC, Dixon R, Vervoort J; , Eur J Biochem 2004;271:1198-1208.: The PAS fold: a redefination of the PAS domain based upon structural prediction. PUBMED:15009198 EPMC:15009198

Members

This clan contains the following 13 member families:

MEKHLA PAS PAS_10 PAS_11 PAS_2 PAS_3 PAS_4 PAS_5 PAS_6 PAS_7 PAS_8 PAS_9 PocR

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PAS_9 (PF13426) 26423 (30.0%) View
PAS (PF00989) 15580 (17.7%) View
PAS_4 (PF08448) 13956 (15.8%) View
PAS_3 (PF08447) 12998 (14.8%) View
PAS_8 (PF13188) 8124 (9.2%) View
PAS_7 (PF12860) 2444 (2.8%) View
PAS_11 (PF14598) 2159 (2.5%) View
PAS_6 (PF08348) 1856 (2.1%) View
PAS_10 (PF13596) 1751 (2.0%) View
PAS_2 (PF08446) 1308 (1.5%) View
PocR (PF10114) 805 (0.9%) View
MEKHLA (PF08670) 387 (0.4%) View
PAS_5 (PF07310) 302 (0.3%) View
Total: 13 Total: 88093 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 3 interactions for this clan. More...

Interacting families
A B
PAS_3 PAS_3
PAS_2 GAF
PAS PAS

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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