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106  structures 1801  species 4  interactions 4482  sequences 90  architectures

Clan: Di-copper (CL0205)

Summary

Di-copper centre-containing domain Add an annotation

This superfamily includes tyrosinases and hemocyanins that share a di-copper centre [1].

This clan contains 2 families and the total number of domains in the clan is 4482. The clan was built by A Bateman.

Literature references

  1. Lerch K, Germann UA; , Prog Clin Biol Res 1988;274:331-348.: Evolutionary relationships among copper proteins containing coupled binuclear copper sites. PUBMED:3136463 EPMC:3136463

Members

This clan contains the following 2 member families:

Hemocyanin_M Tyrosinase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Tyrosinase (PF00264) 3739 (83.4%) View
Hemocyanin_M (PF00372) 743 (16.6%) View
Total: 2 Total: 4482 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
Hemocyanin_M Hemocyanin_N
Hemocyanin_C
Tyrosinase Tyrosinase
MelC1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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