Sequence alignment for CL0239

PF00049

IGF2_BOVIN/30-84ETLCGGELVDTLQ.FVC...GD......R.GFYFSRP...SSR.....................................
BXA2_BOMMO/26-89HTYCGRHLARTMA.DLCW..EEGV..DKRSDAQF.ASY.GSAW.....................................
BXA3_BOMMO/26-92HTYCGRHLARTLA.NLCWEAGVD....KRSDAQYV.SY.GSAW.....................................
BXB1_BOMMO/26-88RTYCGRHLADTLA.DLCF..GVE....KRGGAQY.APY.FWTR.....................................
BXB1_SAMCY/24-91RRYCGRVLADTLA.YLC...PEMEEVEKRSGAQY.AR...YGW.....................................
BXB5_BOMMO/27-88RTYCGRHLANILA.YVCF..GVE....KRGGAQY.APY..WQE.....................................
BXC1_BOMMO/24-89QFYCGDFLARTMS.SLCW..SDM...QKRSGSQY.AGY.GWPW.....................................
BXD1_BOMMO/24-90HIYCGRYLAYKMA.DLCW..RAGF..EKRSVAHY.AGY.GWPL.....................................
IGF1_BOVIN/52-110ETLCGAELVDALQ.FVC...GD......R.GFYFNKP...TGY.....................................
IGF2_ONCMY/53-110ETLCGGELVDALQ.FVC...ED......R.GFYFSRP...TSR.....................................
IGF_MYXGL/41-102ETLCGSELVDTLQ.FVC...DD......R.GFFFV.PQHVPPR.....................................
ILP_BRACL/25-100EYLCGSTLADVLS.FVC...GN......R.GY..N.S...QPRRSVSKRAIDFIS.........................
INS1_MOUSE/28-107QHLCGPHLVEALY.LVC...GE......R.GFFYT.P...KSRREVEDPQVEQLE.........................
INS1_XENLA/27-105QHLCGSHLVEALY.LVC...GD......R.GFFY.YP...KVKRDMEQALVSGPQ.........................
INS_AOTTR/28-107QHLCGPHLVEALY.LVC...GE......R.GFFY.AP...KTRREAEDLQVGQVE.........................
INS_BOVIN/28-104QHLCGSHLVEALY.LVC...GE......R.GFFYT.P...KARREVEGPQVGALEL........................
INS_CANFA/28-109QHLCGSHLVEALY.LVC...GE......R.GFFYT.P...KARREVEDLQVRDVEL........................
INS_CAVPO/28-109RHLCGSNLVETLY.SVC...QD......D.GFFY.IP...KDRRELEDPQVEQTEL........................
INS_CHICK/28-106QHLCGSHLVEALY.LVC...GE......R.GFFY.SP...KARRDVEQPLVSSPL.........................
INS_CYPCA/27-107QHLCGSHLVDALY.LVC...GP......T.GFFYN.P......KRDVDPPLGFLPPKS......................
INS_LOPAM/29-115QHLCGSHLVDALY.LVC...GD......R.GFFYN.P......KRDVDQLLGFLPPKSGGA...................
INS_MYXGL/30-114GHLCGKDLVNALY.IAC...GV......R.GFFYD.P...TKMKRDTGALAAFLPLAY......................
INS_OCTDE/28-106QHLCGSNLVEALY.MTC...GR......S.GF.Y.RP...HDRRELEDLQVEQAE.........................
INS_ONCKE/26-104QHLCGSHLVDALY.LVC...GE......K.GFFYT.P......KRDVDPLIGFLSP........................
INS_RODSP/27-107QHLCGSHLVEALYILVC...GE......R.GFFYT.P...MSRREVEDPQVGQVEL........................
REL1_HUMAN/32-185IKLCGRELVRAQI.AIC...GMST.WSKRSLSQEDAPQ..TPR.....PVAEIVPSFINKDTETIIIMLEFIANL.....
RELX_PIG/31-182IKACGRELVRLWV.EIC...GSV....SW.GR..TAL.......SLEEPQLETGPPAETMPSSITKDAEILKMMLEF.VP
REL1_RAT/33-186IQVCGRGYARAWI.EVCG..ASV....GR.LA..L.S......QEEPAPLARQATAEVVPSFINKDAEPFDMTLKCLPNL

PF03488

Q9TZF3_CAEEL/157-206QRSCGPQLFKRVN-TLC.------------NENINVE-------------------------------------------
Q9TYK2_CAEEL/49-96ELICGRRLSKTVT-NLC.------------VE.MNPQ-------------------------------------------
ILB4_CAEEL/58-105IYRCGRRIHSYVF-AVC.------------GKACESN-------------------------------------------
Q9NEK7_CAEEL/46-93VRACGRRLVPYVW-SVC.------------GDACEPQ-------------------------------------------
ILB3_CAEEL/59-105VKICGTKVLKMVM-VMC.------------GGECSS.-------------------------------------------
Q9U1P6_CAEEL/52-98QKACGRSMMMKVQ-KLCA------------GG.CTIQ-------------------------------------------
Q9TZF3_CAEEL/93-142ERSCGPKLFTRVK-TVC.------------GEDINVD-------------------------------------------
ILB2_CAEEL/55-101KRLCGRRLILFML-ATC.------------GE.CDTD-------------------------------------------
Q9XVA1_CAEEL/34-81YRSCGSHLVHRAF-EACS------------GK.KDRS-------------------------------------------
ILB5_CAEEL/65-112TRACGRKLISLVM-AVC.------------GDLCNPQ-------------------------------------------
ILB1_CAEEL/57-104VRACGRRLLLFVW-STC.------------GEPCTPQ-------------------------------------------

PF00049

IGF2_BOVIN/30-84...............................................................IN...R..RSRG..IVE
BXA2_BOMMO/26-89........................................................LMPY.SAGR.........G..IVD
BXA3_BOMMO/26-92........................................................LMPY.SEGR......GKRG..IVD
BXB1_BOMMO/26-88...........................................................QYLGSR......GKRG..VVD
BXB1_SAMCY/24-91...........................................................QSPESREGAR..GKRG..VVD
BXB5_BOMMO/27-88..........................................................TY.LRSR...K..GP.G..VVD
BXC1_BOMMO/24-89........................................................LPPF.SSSR......GKRG..IVD
BXD1_BOMMO/24-90........................................................LPSL.SEER......GKRG..IAD
IGF1_BOVIN/52-110...........................................................G.SSSR...R.APQTG..IVD
IGF2_ONCMY/53-110.............................................................SNSR...R.SQNRG..IVE
IGF_MYXGL/41-102..........................................................RG.AHRRS..R.ARK.G..IVE
ILP_BRACL/25-100.................................................EQQAKDYMGAM.PHIR...R..RR.G..LVE
INS1_MOUSE/28-107...............................................LGGSPGDLQTLAL.EVAR......QKRG..IVD
INS1_XENLA/27-105...............................................DNELDG.MQLQPQEYQKM.......KRG..IVE
INS_AOTTR/28-107...............................................LGGGSITGSLPPL.EGPM......QKRG..VVD
INS_BOVIN/28-104..............................................AGGPGAGGLEGPPQ............KRG..IVE
INS_CANFA/28-109..............................................AGAPGEGGLQPLAL.EGAL......QKRG..IVE
INS_CAVPO/28-109..............................................GMGLGAGGLQPLAL.EMAL......QKRG..IVD
INS_CHICK/28-106..................................................RGEAGVLPFQ.QEEY...E.KVKRG..IVE
INS_CYPCA/27-107.............................................AQETEVADFAFKDHA.EVIR.......KRG..IVE
INS_LOPAM/29-115..........................................AAAGADNEVAEFAFKDQM.EMMV.......KRG..IVE
INS_MYXGL/30-114.............................................AEDNESQDDESIGIN.EVLK......SKRG..IVE
INS_OCTDE/28-106...............................................LGLEAGGLQPSAL.EMIL......QKRG..IVD
INS_ONCKE/26-104..............................................KSAKENE.EYPFKDQTEMM......VKRG..IVE
INS_RODSP/27-107..............................................GAGPGAGSEQTLAL.EVAR......QAR...IVQ
REL1_HUMAN/32-185PPELKAALSERQPSLPELQQYVPALKDSNLSFEEFKKLIRNRQSEAADSNPSELKYLGLD.THSQKKRR..PYVA..LFE
RELX_PIG/31-182NLPQELKATLSERQPSLRELQQSASKDSNLNFEEFKKIILNRQNEAEDKSLLELKNLGLD.KHSRK.KRLFRMT...LSE
REL1_RAT/33-186SEERKAALSEGRAPFPELQQHAPALSDSVVSLEGFKKTFHNQLGEAEDGGPPELKYLGSD.AQSR...K.KRQSGALLSE

PF03488

Q9TZF3_CAEEL/157-206-------------------------------------------------------------NNVS------------VSK
Q9TYK2_CAEEL/49-96-------------------------------------------------------------KEED------------IAT
ILB4_CAEEL/58-105-------------------------------------------------------------TEVN------------IAS
Q9NEK7_CAEEL/46-93-------------------------------------------------------------EGID------------IAT
ILB3_CAEEL/59-105-------------------------------------------------------------TNEN------------IAT
Q9U1P6_CAEEL/52-98-------------------------------------------------------------ND.D------------LTI
Q9TZF3_CAEEL/93-142-------------------------------------------------------------NKVK------------ISD
ILB2_CAEEL/55-101-------------------------------------------------------------SSED------------LSH
Q9XVA1_CAEEL/34-81-------------------------------------------------------------SDVD------------LWK
ILB5_CAEEL/65-112-------------------------------------------------------------EGKD------------IAT
ILB1_CAEEL/57-104-------------------------------------------------------------EDMD------------IAT

PF00049

IGF2_BOVIN/30-84ECCFRS--CDLALLETYC--
BXA2_BOMMO/26-89ECCLRP--CSVDVLLSYC--
BXA3_BOMMO/26-92ECCLRP--CSVDVLLSYC--
BXB1_BOMMO/26-88ECCFRP--CTLDVLLSYC--
BXB1_SAMCY/24-91ECCYNS--CTLDVLLSYC--
BXB5_BOMMO/27-88ECCFRP--CKLEVLKSYC--
BXC1_BOMMO/24-89ECCYRP--CTIDVLMSYC--
BXD1_BOMMO/24-90ECCLQP--CTNDVLLSYC--
IGF1_BOVIN/52-110ECCFRS--CDLRRLEMYC--
IGF2_ONCMY/53-110ECCFRS--CDLNLLEQYC--
IGF_MYXGL/41-102ECCFKG--CSLRLLEMYC--
ILP_BRACL/25-100ECCYNV--CDYSQLESYC--
INS1_MOUSE/28-107QCCTSI--CSLYQLENYC--
INS1_XENLA/27-105QCCHST--CSLFQLESYC--
INS_AOTTR/28-107QCCTSI--CSLYQLQNYC--
INS_BOVIN/28-104QCCASV--CSLYQLENYC--
INS_CANFA/28-109QCCTSI--CSLYQLENYC--
INS_CAVPO/28-109QCCTGT--CTRHQLQSYC--
INS_CHICK/28-106QCCHNT--CSLYQLENYC--
INS_CYPCA/27-107QCCHKP--CSIFELQNYC--
INS_LOPAM/29-115QCCHRP--CNIFDLQNYC--
INS_MYXGL/30-114QCCHKR--CSIYDLENYC--
INS_OCTDE/28-106QCCNNI--CTFNQLQNYC--
INS_ONCKE/26-104QCCHKP--CNIFDLQNYC--
INS_RODSP/27-107QCTSGI--CSLYQ.ENYC--
REL1_HUMAN/32-185KCCLIG--CTKRSLAKYC--
RELX_PIG/31-182KCCQVG--CIRKDIARLC--
REL1_RAT/33-186QCCHIG--CTRRSIAKLC--

PF03488

Q9TZF3_CAEEL/157-206SCCESAAGCTDDWIKKNVCT
Q9TYK2_CAEEL/49-96KCCKNK.GCSREYIKSIMCP
ILB4_CAEEL/58-105KCCREE..CTDDFIRKQCCP
Q9NEK7_CAEEL/46-93QCCTYQ..CTAEYIQTACCP
ILB3_CAEEL/59-105ECCEKM..CTMEDITTKCCP
Q9U1P6_CAEEL/52-98KSCSTG..YTDAGFISACCP
Q9TZF3_CAEEL/93-142HCCTPEGGCTDDWIKENVCK
ILB2_CAEEL/55-101ICCIKQ..CDVQDIIRVCCP
Q9XVA1_CAEEL/34-81MCCKDE..CTDLDIKESLCK
ILB5_CAEEL/65-112ECCGNQ..CSDDYIRSACCP
ILB1_CAEEL/57-104VCCTTQ..CTPSYIKQACCP

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
Close window