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24  structures 2901  species 2  interactions 4878  sequences 78  architectures

Clan: 2H (CL0247)

Summary

2H phosphoesterase superfamily Add an annotation

This clan includes a number of phosphoesterases that contain an internal duplication.

This clan contains 9 families and the total number of domains in the clan is 4878. The clan was built by A Bateman.

Literature references

  1. Mazumder R, Iyer LM, Vasudevan S, Aravind L; , Nucleic Acids Res 2002;30:5229-5243.: Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily. PUBMED:12466548 EPMC:12466548

Members

This clan contains the following 9 member families:

2_5_RNA_ligase2 2H-phosphodiest AKAP7_NLS CNPase Corona_NS2A CPDase DUF1045 HVSL LigT_PEase

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
2_5_RNA_ligase2 (PF13563) 2076 (42.6%) View
LigT_PEase (PF02834) 1248 (25.6%) View
AKAP7_NLS (PF10469) 426 (8.7%) View
DUF1045 (PF06299) 281 (5.8%) View
HVSL (PF09749) 269 (5.5%) View
2H-phosphodiest (PF08975) 265 (5.4%) View
CPDase (PF07823) 138 (2.8%) View
Corona_NS2A (PF05213) 104 (2.1%) View
CNPase (PF05881) 71 (1.5%) View
Total: 9 Total: 4878 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
LigT_PEase LigT_PEase
CPDase CPDase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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