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598  structures 5650  species 23  interactions 93998  sequences 271  architectures

Clan: THDP-binding (CL0254)

Summary

Thiamin diphosphate-binding superfamily Add an annotation

This clan includes pyruvate dehydrogenases, branched chain alpha-keto acid decarboxylases, phosphoketolases and the pyrimidine binding region of transketolases.

This clan contains 9 families and the total number of domains in the clan is 93998. The clan was built by J Mistry and A Bateman.

Literature references

  1. Meile L, Rohr LM, Geissmann TA, Herensperger M, Teuber M; , J Bacteriol 2001;183:2929-2936.: Characterization of the D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase gene (xfp) from Bifidobacterium lactis. PUBMED:11292814 EPMC:11292814
  2. Lindqvist Y, Schneider G, Ermler U, Sundstrom M; , EMBO J 1992;11:2373-2379.: Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution. PUBMED:1628611 EPMC:1628611

Members

This clan contains the following 9 member families:

DXP_synthase_N E1_dh POR_N TPP_enzyme_C TPP_enzyme_N Transket_pyr Transketolase_N XFP XFP_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TPP_enzyme_C (PF02775) 23243 (24.7%) View
Transket_pyr (PF02779) 20295 (21.6%) View
TPP_enzyme_N (PF02776) 17953 (19.1%) View
Transketolase_N (PF00456) 11328 (12.1%) View
E1_dh (PF00676) 9023 (9.6%) View
POR_N (PF01855) 5386 (5.7%) View
DXP_synthase_N (PF13292) 4453 (4.7%) View
XFP (PF03894) 1182 (1.3%) View
XFP_N (PF09364) 1135 (1.2%) View
Total: 9 Total: 93998 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 23 interactions for this clan. More...

Interacting families
A B
TPP_enzyme_C Fer4
TPP_enzyme_M
POR
POR_N
TPP_enzyme_C
TPP_enzyme_N
E1_dh E1_dh
Transket_pyr
Transketolase_C
Transketolase_N Transketolase_N
Transket_pyr
Transketolase_C
Transket_pyr Transketolase_N
E1_dh
Transket_pyr
Transketolase_C
TPP_enzyme_N TPP_enzyme_M
TPP_enzyme_C
TPP_enzyme_N
POR_N POR
POR_N
TPP_enzyme_C
EKR

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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