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48  structures 3410  species 2  interactions 3949  sequences 23  architectures

Clan: CYTH (CL0273)

Summary

CYTH-like phosphatase superfamily Add an annotation

CyaB like adenylyl cyclase and the mammalian thiamine triphosphatases define a novel superfamily of catalytic domains called the CYTH domain that is present in all three superkingdoms of life. The catalytic core of these enzymes contain a novel alpha beta scaffold with 6 conserved acidic residues and 4 basic residues [1].

This clan contains 2 families and the total number of domains in the clan is 3949. The clan was built by A Bateman.

Literature references

  1. Iyer LM, Aravind L; , BMC Genomics 2002;3:33-33.: The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates. PUBMED:12456267 EPMC:12456267

Members

This clan contains the following 2 member families:

CYTH mRNA_triPase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CYTH (PF01928) 3690 (93.4%) View
mRNA_triPase (PF02940) 259 (6.6%) View
Total: 2 Total: 3949 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
CYTH CYTH
mRNA_triPase mRNA_triPase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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