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929  structures 4080  species 5  interactions 40864  sequences 1227  architectures

Clan: Transthyretin (CL0287)

Summary

Transthyretin superfamily Add an annotation

This clan unifies several SCOP superfamilies that all share a 7 stranded beta sandwich fold.

This clan contains 13 families and the total number of domains in the clan is 40864. The clan was built by A Bateman.

Members

This clan contains the following 13 member families:

CarboxypepD_reg Cna_B Dioxygenase_C DUF1416 DUF2012 DUF2606 DUF3823 DUF4480 FctA fn3_3 PEGA phage_tail_N Transthyretin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cna_B (PF05738) 13573 (33.2%) View
DUF4480 (PF13715) 11370 (27.8%) View
CarboxypepD_reg (PF13620) 6052 (14.8%) View
Dioxygenase_C (PF00775) 2905 (7.1%) View
Transthyretin (PF00576) 1803 (4.4%) View
FctA (PF12892) 1757 (4.3%) View
PEGA (PF08308) 1445 (3.5%) View
phage_tail_N (PF08400) 1004 (2.5%) View
fn3_3 (PF14686) 306 (0.7%) View
DUF2012 (PF09430) 303 (0.7%) View
DUF1416 (PF07210) 209 (0.5%) View
DUF3823 (PF12866) 92 (0.2%) View
DUF2606 (PF10794) 45 (0.1%) View
Total: 13 Total: 40864 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
Transthyretin Transthyretin
Cna_B Molybdopterin
Cna_B
Dioxygenase_C Dioxygenase_C
Dioxygenase_N

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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