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250  structures 4602  species 7  interactions 13173  sequences 83  architectures

Clan: SHS2 (CL0319)

Summary

SHS2 domain Add an annotation

SHS2 is a novel domain with a simple fold containing a core of 3 strands, forming a curved sheet, and a single helix in a strand-helix-strand-strand (SHS2) configuration [1]. SHS2 is found in the bacterial cell division ATPase FtsA, the archaeo-eukaryotic RNA polymerase subunit Rpb7p, the GyrI superfamily, and the uncharacterized MTH1598/Tm1083-like proteins [1]. The fold exists as single copy versions in FtsA (where it is inserted into the RNAseH fold), Rbp7p and Dodecin [1]. It is found as a diad in the GyrI superfamily. In MTH1598/Tm1083-like proteins two copies of SHS2 are found with one inserted into another [1]. The single-copy versions in FtsA and Rbp7 mediate protein–protein interactions, while the one in Dodecin is a small molecule binding domain. The GyrI also binds small molecule, while the MTH1598 is predicted to be enzymatic [1].

This clan contains 7 families and the total number of domains in the clan is 13173. The clan was built by A Bateman and V Anantharaman.

Literature references

  1. Anantharaman V, Aravind L;, Proteins. 2004;56:795-807.: The SHS2 module is a common structural theme in functionally diverse protein groups, like Rpb7p, FtsA, GyrI, and MTH1598/TM1083 superfamilies. PUBMED:15281131 EPMC:15281131
  2. Dias JS, Macedo AL, Ferreira GC, Peterson FC, Volkman BF, Goodfellow BJ; , J Biol Chem. 2006;281:31553-31561.: The first structure from the SOUL/HBP family of heme-binding proteins, murine P22HBP. PUBMED:16905545 EPMC:16905545
  3. Canaves JM; , Proteins. 2004;56:19-27.: Predicted role for the archease protein family based on structural and sequence analysis of TM1083 and MTH1598, two proteins structurally characterized through structural genomics efforts. PUBMED:15162483 EPMC:15162483
  4. Bieger B, Essen LO, Oesterhelt D;, Structure. 2003;11:375-385.: Crystal structure of halophilic dodecin: a novel, dodecameric flavin binding protein from Halobacterium salinarum. PUBMED:12679016 EPMC:12679016

Members

This clan contains the following 7 member families:

Archease Cass2 Dodecin GyrI-like SHS2_FTSA SHS2_Rpb7-N SOUL

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GyrI-like (PF06445) 6066 (46.0%) View
SHS2_FTSA (PF02491) 3487 (26.5%) View
SHS2_Rpb7-N (PF03876) 1033 (7.8%) View
Cass2 (PF14526) 758 (5.8%) View
SOUL (PF04832) 715 (5.4%) View
Dodecin (PF07311) 611 (4.6%) View
Archease (PF01951) 503 (3.8%) View
Total: 7 Total: 13173 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 7 interactions for this clan. More...

Interacting families
A B
Dodecin Dodecin
SHS2_FTSA MreB_Mbl
SHS2_Rpb7-N S1
RNA_pol_Rpb1_2
RNA_pol_Rpb6
RNA_pol_Rpb4
RNA_pol_Rpb2_7

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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