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423  structures 4568  species 5  interactions 17543  sequences 52  architectures

Clan: THBO-biosyn (CL0334)

Summary

Tetrahydrobiopterin biosynthesis-like enzyme superfamily Add an annotation

The families in this clan bind purine or ptein in topologically similar sites between subunits.

This clan contains 6 families and the total number of domains in the clan is 17543. The clan was built by P Coggill.

Members

This clan contains the following 6 member families:

FolB GTP_cyclohydroI PTPS QueF QueF_N Uricase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
FolB (PF02152) 4525 (25.8%) View
GTP_cyclohydroI (PF01227) 4297 (24.5%) View
PTPS (PF01242) 3812 (21.7%) View
QueF (PF14489) 2821 (16.1%) View
QueF_N (PF14819) 1208 (6.9%) View
Uricase (PF01014) 880 (5.0%) View
Total: 6 Total: 17543 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
FolB FolB
Uricase Uricase
PTPS PTPS
GTP_cyclohydroI GTP_cyclohydroI
GFRP

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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