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366  structures 6690  species 16  interactions 129668  sequences 2266  architectures

Clan: 4Fe-4S (CL0344)

Summary

4Fe-4S ferredoxins Add an annotation

Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.

This clan contains 24 families and the total number of domains in the clan is 129668. The clan was built by A Bateman.

Members

This clan contains the following 24 member families:

ETF_QO Fer4 Fer4_10 Fer4_11 Fer4_12 Fer4_13 Fer4_14 Fer4_15 Fer4_16 Fer4_17 Fer4_18 Fer4_19 Fer4_2 Fer4_20 Fer4_21 Fer4_3 Fer4_4 Fer4_5 Fer4_6 Fer4_7 Fer4_8 Fer4_9 FeS RLI

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Fer4_7 (PF12838) 18155 (14.0%) View
Fer4_12 (PF13353) 15922 (12.3%) View
Fer4_11 (PF13247) 12420 (9.6%) View
Fer4_8 (PF13183) 10837 (8.4%) View
Fer4_14 (PF13394) 9987 (7.7%) View
Fer4 (PF00037) 8206 (6.3%) View
Fer4_10 (PF13237) 7356 (5.7%) View
Fer4_20 (PF14691) 6849 (5.3%) View
Fer4_5 (PF12801) 6537 (5.0%) View
Fer4_9 (PF13187) 5796 (4.5%) View
Fer4_4 (PF12800) 4289 (3.3%) View
Fer4_17 (PF13534) 4064 (3.1%) View
Fer4_21 (PF14697) 3437 (2.7%) View
continued
Pfam family Num. domains Alignment
Fer4_16 (PF13484) 3179 (2.5%) View
FeS (PF04060) 2487 (1.9%) View
Fer4_15 (PF13459) 1717 (1.3%) View
Fer4_18 (PF13746) 1675 (1.3%) View
Fer4_2 (PF12797) 1399 (1.1%) View
ETF_QO (PF05187) 1342 (1.0%) View
Fer4_13 (PF13370) 1093 (0.8%) View
RLI (PF04068) 889 (0.7%) View
Fer4_6 (PF12837) 737 (0.6%) View
Fer4_19 (PF06902) 670 (0.5%) View
Fer4_3 (PF12798) 625 (0.5%) View
Total: 24 Total: 129668 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 16 interactions for this clan. More...

Interacting families
A B
Fer4 Fer4
Fer2
PsaA_PsaB
FAD_binding_2
DHO_dh
POR
Fe_hyd_SSU
Fumarate_red_C
Fumarate_red_D
PSI_PsaE
PsaD
TPP_enzyme_C
Fe_hyd_lg_C
Succ_DH_flav_C
Form-deh_trans
EKR

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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