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149  structures 6257  species 1  interaction 68785  sequences 2269  architectures

Clan: ANL (CL0378)

Summary

ANL superfamily Add an annotation

This superfamily consists of enzymes including luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely-related synthetases as well as a plant auxin-responsive promoter family. The name ANL derives from from three of the subfamilies - Acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes [1]. Members of this superfamily catalyse the initial adenylation of a carboxylate to form an acyl-AMP intermediate, followed by a second partial reaction, most commonly the formation of a thioester [1].

This clan contains 3 families and the total number of domains in the clan is 68785. The clan was built by A Bateman.

Literature references

  1. Gulick AM;, ACS Chem Biol. 2009;4:811-827.: Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase. PUBMED:19610673 EPMC:19610673

Members

This clan contains the following 3 member families:

AMP-binding GH3 LuxE

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AMP-binding (PF00501) 67453 (98.1%) View
GH3 (PF03321) 945 (1.4%) View
LuxE (PF04443) 387 (0.6%) View
Total: 3 Total: 68785 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
AMP-binding AMP-binding

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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