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9  structures 886  species 1  interaction 2617  sequences 44  architectures

Clan: Tubby_C (CL0395)

Summary

Tubby C-terminal domain-like Add an annotation

This superfamily contains the scramblase protein family, the Tub family and the DUF567, a family of plant and bacterial proteins of hitherto unknown function. All members are membrane-tethered transcription factors.

This clan contains 3 families and the total number of domains in the clan is 2617. The clan was built by A Bateman.

Literature references

  1. Bateman A, Finn RD, Sims PJ, Wiedmer T, Biegert A, Soding J;, Bioinformatics. 2009;25:159-162.: Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors. PUBMED:19010806 EPMC:19010806

Members

This clan contains the following 3 member families:

Scramblase Tub Tub_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Tub_2 (PF04525) 987 (37.7%) View
Tub (PF01167) 847 (32.4%) View
Scramblase (PF03803) 783 (29.9%) View
Total: 3 Total: 2617 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
Tub Tub

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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