Sequence alignment for CL0451

PF00093

TSP2_MOUSE/320-374-----------------CV.QEGRIFAENETWVVDS........CT.TCTCKK........FKTVC----------HQIT
VWF_HUMAN/2431-2494-----------------CV.HRSTIYPVGQFWEEG.........CD.VCTCTDMEDAVMGLRVAQC----------SQKP
VWF_HUMAN/2257-2325-----------------CIGEDGVQHQFLEAWVPDHQ......PCQ.ICTCLS.......GRKVNC----------TTQP
VWF_HUMAN/2582-2644-----------------CM.LNGTVIGPGKTVMIDV........CT.TCRCMVQVG.VISGFKLEC----------RKTT
CO1A1_HUMAN/40-95-----------------CV.QNGLRYHDRDVWKPEP........CR.ICVCDN........GKVLC----------DDVI
TSP2_HUMAN/320-374-----------------CW.QDGRFFAENETWVVDS........CT.TCTCKK........FKTIC----------HQIT
CO5A2_HUMAN/41-96-----------------CT.QNGQMYLNRDIWKPAP........CQ.ICVCDN........GAILC----------DKIE
CO1A1_CHICK/33-88-----------------CV.QDGLTYNDKDVWKPEP........CQ.ICVCDS........GNILC----------DEVI
CO3A1_MOUSE/33-89-----------------CS.HLGQSYESRDVWKPEP........CQ.ICVCDS........GSVLC----------DDII
SOG_DROME/941-1019-----------------CK.VVNKVYENGQEWHPILMSH.GEQKCI.KCRCKD........SKVNC----------DRKR
TSP1_HUMAN/318-372-----------------CY.HNGVQYRNNEEWTVDS........CT.ECHCQN........SVTIC----------KKVS
TSP2_CHICK/326-380-----------------CW.QDGRVFADSESWIVDS........CT.KCTCQD........SKIVC----------HQIT
TSP1_XENLA/321-375-----------------CL.HNGVLHKNRDEWTVDS........CT.ECTCQN........SATIC----------RKVS
CYR61_CHICK/100-163-----------------CE.YNSKIYQNGESFQPN.........CKHQCTCID........GAVGC----------IPL.
NOV_CHICK/106-169-----------------CV.FDGMIYRNGETFQPS.........CKYQCTCRD........GQIGC----------LPR.
SOG_DROME/832-898-----------------CR.LGEQFHPAGASWHPFLPPN.GFDTCT.TCSCDPL......TLEIRC----------PRLV
CO2A1_MOUSE/34-88-----------------CL.QNGQRYKDKDVWKPSS........CR.ICVCDT........GNVLC----------DDII
SOG_DROME/744-803-----------------CF.HSGRFYNESEQWRSAQD......SCQ.MCACLR........GQSSC----------EVIK
CTGF_HUMAN/103-166-----------------CI.FGGTVYRSGESFQSS.........CKYQCTCLD........GAVGC----------MPL.
SOG_DROME/102-174-----------------CQ.FGKVLRELGSTWYADLGPPFGVMYCI.KCECVAIPKKRRIVARVQC----------RNIK

PF12714

B4DYT6_HUMAN/57-112----------------GCLHPAGSYFKVGERWYKPG.-------CKELCVCES-------NNRIRC----------QPWR
B4DYT6_HUMAN/742-798----------------GCKDAHGGSIPLGKSWVSSG.-------CTEKCVC.T-------GGAIQC----------GDFR
B4DYT6_HUMAN/1029-1079----------------GTAPS.....ALGSSFLTED.-------CSQRCTCAS-------SRILLC----------EPFS
C3YHS2_BRAFL/245-297----------------PPCYFHGNAYPSGEWWTY...-------ACKECTC.E-------CGQVVC----------QPVQ
C3YHS2_BRAFL/348-403----------------PPCYVNGNVIPSGEWWTNTIT-------ACTECTC.L-------CGQVQC----------QPIK
ZAN_MOUSE/1221-1275----------------NCP.YNNKHYKPGEEWFTPN.-------CTERCRCLP-------GSLMEC----------QISQ
ZAN_MOUSE/1609-1664----------------GCTSFQGRYFKLQEQWFNPD.-------CKEICTCES-------HNHILC----------KPWK
ZAN_MOUSE/2399-2454----------------GCKDAQGVFIPAGKTWISED.-------CTQSCTC.M-------KGSMRC----------WDFQ
ZAN_MOUSE/2519-2574----------------GCQHTQGGFIPAGKNWTSRG.-------CSQSCDC.M-------EGVIRC----------QNFQ
ZAN_MOUSE/2639-2694----------------GCKDAQGVLIPADKIWINKG.-------CTQTCAC.V-------TGTIHC----------RDFQ
ZAN_MOUSE/2759-2814----------------GCKDAQGVLIPAGKTWINRG.-------CTQSCSC.M-------GGAIQC----------QNFK
ZAN_MOUSE/2879-2934----------------GCKDTQGVLIPADKTWINRG.-------CTQSCTC.R-------GGAIQC----------QKYH
ZAN_MOUSE/3119-3174----------------GCKDAQGALIPEGKTWITSG.-------CTQSCNC.T-------GGAIQC----------QNFQ
ZAN_MOUSE/3239-3294----------------GCKNTQGAFISADKTWISRG.-------CTQSCTC.P-------AGAIHC----------RNFK
ZAN_MOUSE/3356-3411----------------GCKDARGAIIPAGKTWTSKG.-------CTQSCAC.V-------EGNIQC----------QNFQ
ZAN_MOUSE/3476-3531----------------DCKDAQGALIPAGKTWTSPG.-------CTQSCAC.M-------GGAVQC----------QSSQ
ZAN_MOUSE/3596-3651----------------GCKDAHGALIPEDKTWVSRG.-------CTQSCVC.T-------GGSIQC----------LSSQ
ZAN_MOUSE/3836-3887----------------GCRDTQGAVIPAGKTWLSTG.-------CIQSCAC.V-------EGTIQC----------QNFQ
ZAN_MOUSE/3952-4007----------------DCKDAEGGLVPAGKTWTSKD.-------CTQSCAC.T-------GGAVQC----------QNFQ
ZAN_MOUSE/4088-4143----------------GCKDTQGGLIPAGRTWISSD.-------CTKSCSC.M-------GGIIQC----------RDFQ
ZAN_MOUSE/4208-4258----------------GCKDAQGGFVPAGKTWISRG.-------CTQSCAC.V-------GGAVQC----------HNFT
ZAN_MOUSE/4323-4378----------------GCKDAQGDLIPANKTWLTRG.-------CAQKCTC.K-------GGNIHC----------WNFK
ZAN_MOUSE/4443-4498----------------GCKDSQGTLIPAGKNWITTG.-------CSQRCTC.T-------GGLVQC----------HDFQ
ZAN_MOUSE/4563-4618----------------GCKDAHGVLIPESKTWVSRG.-------CTKNCTC.K-------GGTVQC----------HDFS
ZAN_MOUSE/4683-4738----------------DCKDFQGSLIKTGQTWISSG.-------CSKICTC.K-------GGFFQC----------QSYK
ZAN_MOUSE/4803-4858----------------GCKDIRGNIIPAGNTWISSD.-------CTQSCAC.T-------DGVIQC----------QNFV
ZAN_MOUSE/5204-5258----------------GCT.ADGIYYKLGDSFVTND.-------CSQHCTCAS-------QGILLC----------EPYG
ZAN_RABIT/551-605----------------PCL.YNNNNYEPEAEWFSPN.-------CTELCHCWP-------GGRIEC----------QISQ
ZAN_RABIT/935-990----------------GCLDPSRGYFKVGEQWFKSD.-------CKQLCICEG-------SNQIRC----------QPWK
ZAN_RABIT/1323-1379----------------GCTDFEGSYHLVRESWYTDNT-------CSRLCTCSL-------HNNITC----------RQTA
ZAN_RABIT/1727-1782----------------SCRDAQGGSIPSGKSWVSSG.-------CSQKCAC.T-------EGSIQC----------RAFH
ZAN_RABIT/2130-2184----------------GCT.SNGIYYQLGHSFVTAD.-------CSQRCTCAS-------SGVLLC----------EPFS
ZAN_PIG/740-794----------------DCF.YNDNYYKLGTDWFSPN.-------CTEHCHCRP-------SSRMEC----------QTFK
ZAN_PIG/1512-1568----------------GCTTQRGSYHPVGESWYTDNS-------CSRLCTCSA-------HNNISC----------RQAS
ZAN_PIG/1908-1963----------------GCRDARGTFLPVGRFRLSSG.-------CSQMCVC.T-------AGAIEC----------RPFT
Q2EG66_PANPA/234-288----------------NCF.YNNDYYEPGAEWFSPN.-------CTEHYRCWP-------GSRVEC----------QISQ
Q2EG66_PANPA/1008-1064----------------GCTDPAGSYHPVGEHWYTENT-------CTRLCTCSV-------HNNITC----------FQST
Q3ZTP0_MICMU/53-107----------------DCF.YNNYNYKTGAEWFSPN.-------CTEYCHCWP-------GNQIEC----------QSSQ
Q3ZTP0_MICMU/437-492----------------GCLDFKGSYFKVGEKWYKPG.-------CRQLCVCKD-------NNRIRC----------YSWK
Q3ZTP0_MICMU/1216-1272----------------GCEDAQGGLIPPGKTWISSG.-------CTDSCVC.M-------GGTIQC----------RAFR
Q4T7B5_TETNG/120-176----------------DATTRTESYRPVGDTWFTSKN-------CSERCKCNG-------NHNVTC----------EPWQ
Q4T7B5_TETNG/508-564----------------GCLDSDREYHDVGDTWLTDK.-------CGQSCTCNI-------GGKITC----------KDHT

PF05825

MSMB_MOUSE/21-113VCSIENREIFPNQMSDDCMDADGNKHFLNTPWK.KN--------CT-WCSCDK--------TSITCCTNATRPLSYDKDN
MSMB_RAT/21-113ACSIQRLKRLPNEKSDECTDVDGGKHVLNTYWQ.KN--------CE-WCFCEK--------TAITCCTKTLIPVSYDKKR
MSPE_SAGOE/21-114SCYVIRHKIVPGETIKECTDLKGNKHPLDSRWRTED--------CE-LCACRD--------IEISCCSLVSTPVGYDRHN
MSMB_PIG/21-111QCYFIPNQSL...KPNECQDLKGVSHPLNSVWKTKD--------CE-ECTCGQ--------NAISCCNTAAIPTGYDTNK
MSMB_MACMU/21-114SCSFIPNERFPGDSTRECTDLKGNKHPINSKWKTDN--------CE-RCTCYK--------TEIICCTLIATPVGYDKKK
MSPJ_SAGOE/21-114SCYIILNDMIPGDSTNECTDLKGNKHPINSKWRTDN--------CD-SCTCRE--------KEISCCTLVSTPVGYDTHK

PF00093

TSP2_MOUSE/320-374..CSP......ATCANP................SFVEGECCP..SC--
VWF_HUMAN/2431-2494..CE.......DSCRSG.............FTYVLHEGECCG..RC--
VWF_HUMAN/2257-2325..CPTAKAPTCGLCEVA..............RLRQNADQCCPEYEC--
VWF_HUMAN/2582-2644..C........NPCPLG.............YKEENNTGECCG..RC--
CO1A1_HUMAN/40-95..CDE.....TKNCPGA................EVPEGECCP..VC--
TSP2_HUMAN/320-374..CPP......ATCASP................SFVEGECCP..SC--
CO5A2_HUMAN/41-96..CQD.....VLDCADP................VTPPGECCP..VC--
CO1A1_CHICK/33-88..CED.....TSDCPNA................EIPFGECCP..IC--
CO3A1_MOUSE/33-89..CDEE....PLDCPNP................EIPFGECCA..IC--
SOG_DROME/941-1019..CSR......STCQQQTRVTSKRRLFEKPDAAAPAIDECCS.TQC--
TSP1_HUMAN/318-372..CPI......MPCSNAT............VP....DGECCP..RC--
TSP2_CHICK/326-380..CPP......VSCADP.............SF...IEGECCP..VC--
TSP1_XENLA/321-375..CPL......MPCTNA................TIPDGECCP..RC--
CYR61_CHICK/100-163..CPQELSLPNLGCPSP..............RLVKVPGQCCEEWVC--
NOV_CHICK/106-169..CNLGLLLPGPDCPFP..............RKIEVPGECCEKWVC--
SOG_DROME/832-898..CPP......LQCSEK.............LAYRPDKKACCK..IC--
CO2A1_MOUSE/34-88..CED......PDCLNP................EIPFGECCP..IC--
SOG_DROME/744-803..CPA......LKCKST.............EQLLQRDGECCP..SC--
CTGF_HUMAN/103-166..CSMDVRLPSPDCPFP..............RRVKLPGKCCEEWVC--
SOG_DROME/102-174NECPP......AKCDDP................ISLPGKCCK..TC--

PF12714

B4DYT6_HUMAN/57-112--CRA-----QEFCGQQ----------------..DGIYGCH------
B4DYT6_HUMAN/742-798--CPS-----GSHCQLT----------------SDNSNSNCV------
B4DYT6_HUMAN/1029-1079--CRA-----GEVCTLG----------------..NHTQGCF------
C3YHS2_BRAFL/245-297--CPP-----VTVPTCE----------------..NGAVLEE------
C3YHS2_BRAFL/348-403--CPP-----VTVPECV----------------..NGAEPEY------
ZAN_MOUSE/1221-1275--CGT-----HTVCQLK----------------..SDQYQCE------
ZAN_MOUSE/1609-1664--CKA-----QEACSYK----------------..NGVLGCH------
ZAN_MOUSE/2399-2454--CPP-----GTYCKNS----------------N.DGSSNCV------
ZAN_MOUSE/2519-2574--CPS-----GTYCQDI----------------E.DGTSNCA------
ZAN_MOUSE/2639-2694--CPS-----GTYCKDI----------------K.DDASNCT------
ZAN_MOUSE/2759-2814--CPS-----EAYCQDM----------------E.DGNSNCT------
ZAN_MOUSE/2879-2934--CSS-----GTYCKDM----------------E.DDSSSCA------
ZAN_MOUSE/3119-3174--CPL-----KTYCKDL----------------K.DGSSNCT------
ZAN_MOUSE/3239-3294--CPS-----GTYCKNG----------------D.NGSSNCT------
ZAN_MOUSE/3356-3411--CPP-----ETYCKDN----------------S.EGSSTCT------
ZAN_MOUSE/3476-3531--CPP-----GTYCKDN----------------E.DGNSNCA------
ZAN_MOUSE/3596-3651--CPP-----GAYCKDN----------------E.DGSSNCA------
ZAN_MOUSE/3836-3887--CPP-----GTYC...----------------..NHNNNCA------
ZAN_MOUSE/3952-4007--CPL-----GTYCKDS----------------G.DGSSNCT------
ZAN_MOUSE/4088-4143--CPP-----GTYCKES----------------N.DSSRTCA------
ZAN_MOUSE/4208-4258--CPT-----GTQCQ..----------------....NSSCS------
ZAN_MOUSE/4323-4378--CPL-----GTECKDS----------------V.DGGSNCT------
ZAN_MOUSE/4443-4498--CPS-----GAECQDI----------------E.DGNSNCV------
ZAN_MOUSE/4563-4618--CPT-----GSRCLDN----------------N.EGNSNCV------
ZAN_MOUSE/4683-4738--CPS-----GTQCEES----------------E.DGSSNCV------
ZAN_MOUSE/4803-4858--CPS-----GSHCQYN----------------E.DGSSDCA------
ZAN_MOUSE/5204-5258--CRA-----GESCMVA----------------..NFTRGCF------
ZAN_RABIT/551-605--CKT-----HTKCQLK----------------..NGQYECQ------
ZAN_RABIT/935-990--CGP-----HEVCSQQ----------------..SGIYGCH------
ZAN_RABIT/1323-1379--CKP-----GQQCWAV----------------..DGLLRCR------
ZAN_RABIT/1727-1782--CPS-----RSHCKLN----------------S.NGNSNCV------
ZAN_RABIT/2130-2184--CRP-----GESCTLG----------------..NLTRGCF------
ZAN_PIG/740-794--CGT-----HTVCQLK----------------..NGQYGCH------
ZAN_PIG/1512-1568--CKP-----SQMCWPQ----------------..DGLIRCR------
ZAN_PIG/1908-1963--CPS-----GSQCEPN----------------E.DGKDFCQ------
Q2EG66_PANPA/234-288--CGT-----HTVCQLK----------------..NGQYGCH------
Q2EG66_PANPA/1008-1064--CKP-----NQICWAL----------------..DGLLRCQ------
Q3ZTP0_MICMU/53-107--CGA-----RTMCQLK----------------..NGQYGCY------
Q3ZTP0_MICMU/437-492--CKA-----QEICDYQ----------------..DGIYGCH------
Q3ZTP0_MICMU/1216-1272--CPS-----GSHCQPS----------------SDHSNSNCA------
Q4T7B5_TETNG/120-176--CSP-----AQECKVV----------------..DGLLDCH------
Q4T7B5_TETNG/508-564--CGS-----NSVCELD----------------K.YGDYICK------

PF05825

MSMB_MOUSE/21-113--CDV--QFHPENCTYS-------------VVDRKNPGKTCRVDSWTM
MSMB_RAT/21-113--CQR--QFHSENCTYS-------------VVERTNPGKTCPVNGWTI
MSPE_SAGOE/21-114--CRK--IFNKETCKIS-------------VVEKTDPNRPCGVSGWIS
MSMB_PIG/21-111--CQK--ILNKKTCTYT-------------VVEKKDPGKTCDVTGWVL
MSMB_MACMU/21-114--CQR--IFKKEDCKYI-------------VVEKKNPKKTCPIDQWIL
MSPJ_SAGOE/21-114--CQK--IFNKEDCRIS-------------VVEKNDPSKTCEVNAWIM

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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