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168  structures 3000  species 7  interactions 134027  sequences 6571  architectures

Clan: Ank (CL0465)

Summary

Ankyrin repeat superfamily Add an annotation

The ankyrin repeat is a short sequence region that is about 30-34 amino-acids in length. Multiple copies of the repeat composed of two beta strands and two alpha helices combine to form long arrays. In general these repeats are involved in protein-protein interactions. This superfamily also includes some families that are arrays of several repeats.

This clan contains 7 families and the total number of domains in the clan is 134027. The clan was built by A Bateman.

Literature references

  1. Sedgwick SG, Smerdon SJ;, Trends Biochem Sci. 1999;24:311-316.: The ankyrin repeat: a diversity of interactions on a common structural framework. PUBMED:10431175 EPMC:10431175
  2. Mosavi LK, Cammett TJ, Desrosiers DC, Peng ZY;, Protein Sci. 2004;13:1435-1448.: The ankyrin repeat as molecular architecture for protein recognition. PUBMED:15152081 EPMC:15152081
  3. Li J, Mahajan A, Tsai MD;, Biochemistry. 2006;45:15168-15178.: Ankyrin repeat: a unique motif mediating protein-protein interactions. PUBMED:17176038 EPMC:17176038

Members

This clan contains the following 7 member families:

Ank Ank_2 Ank_3 Ank_4 Ank_5 DUF3420 DUF3447

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ank_2 (PF12796) 110723 (82.6%) View
Ank (PF00023) 8812 (6.6%) View
Ank_4 (PF13637) 7425 (5.5%) View
Ank_5 (PF13857) 5157 (3.8%) View
DUF3447 (PF11929) 1243 (0.9%) View
Ank_3 (PF13606) 446 (0.3%) View
DUF3420 (PF11900) 221 (0.2%) View
Total: 7 Total: 134027 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 7 interactions for this clan. More...

Interacting families
A B
Ank SH3_1
Ank
Pkinase
RHD
P53
ArfGap
TIG

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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