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8  structures 1725  species 1  interaction 4317  sequences 49  architectures

Clan: SUKH (CL0526)

Summary

SUKH superfamily Add an annotation

SUKH superfamily unites a diverse group of proteins including Smi1/Knr4, PGs2, Fbxo3, Skip16, Syd, herpesviral US22, IRS1 and TRS1, and their bacterial homologs [1].

This clan contains 7 families and the total number of domains in the clan is 4317. The clan was built by D ZhangLM Iyer and L Aravind.

Literature references

  1. Zhang D, Iyer LM, Aravind L;, Nucleic Acids Res. 2011;39:4532-4552.: A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. PUBMED:21306995 EPMC:21306995

Members

This clan contains the following 7 member families:

SMI1_KNR4 SUKH-3 SUKH-4 SUKH_5 SUKH_6 Syd US22

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SMI1_KNR4 (PF09346) 1863 (43.2%) View
Syd (PF07348) 745 (17.3%) View
US22 (PF02393) 718 (16.6%) View
SUKH_6 (PF14568) 516 (12.0%) View
SUKH-4 (PF14435) 180 (4.2%) View
SUKH-3 (PF14433) 175 (4.1%) View
SUKH_5 (PF14567) 120 (2.8%) View
Total: 7 Total: 4317 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
SMI1_KNR4 SMI1_KNR4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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