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93  structures 200  species 2  interactions 12815  sequences 37  architectures

Clan: Viral_gly_cn_dm (CL0543)

Summary

Viral glycoprotein central and dimerisation domains Add an annotation

Flavivirus and alpha virus glycoprotein E/E1 consists of three domains. A dimerisation domain, a central domain and an immunoglobulin-like domain. The dimerisation and central domains are intertwined [1-3].

This clan contains 2 families and the total number of domains in the clan is 12815. The clan was built by R Eberhardt.

Literature references

  1. Ferlenghi I, Clarke M, Ruttan T, Allison SL, Schalich J, Heinz FX, Harrison SC, Rey FA, Fuller SD;, Mol Cell. 2001;7:593-602.: Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus. PUBMED:11463384 EPMC:11463384
  2. Lescar J, Roussel A, Wien MW, Navaza J, Fuller SD, Wengler G, Wengler G, Rey FA;, Cell. 2001;105:137-148.: The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH. PUBMED:11301009 EPMC:11301009
  3. Modis Y, Ogata S, Clements D, Harrison SC;, Proc Natl Acad Sci U S A. 2003;100:6986-6991.: A ligand-binding pocket in the dengue virus envelope glycoprotein. PUBMED:12759475 EPMC:12759475

Members

This clan contains the following 2 member families:

Alpha_E1_glycop Flavi_glycoprot

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Flavi_glycoprot (PF00869) 10895 (85.0%) View
Alpha_E1_glycop (PF01589) 1920 (15.0%) View
Total: 2 Total: 12815 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
Flavi_glycoprot Flavi_glycoprot
Flavi_glycop_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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