Sequence alignment for CL0547

PF14843

Q6SAX4_DROME/471-583--ICSDQCNEDG--------------------CWGAGT------DQCLTCKNFNFN..........GTCIADCGYI...S
F1M7X4_RAT/502-634--VCNHLCSNDG--------------------CWGPGP------DQCLSCRRFSRG..........KICIESCNLYDGEF
E0W212_PEDHC/466-580--VCDPQCSSEG--------------------CWGPGP------KQCISCINFKNG..........NECVQDCNSI...K
Q923V5_RAT/34-167--VCNSLCAHGH--------------------CWGPGP------TQCVNCSHFLRG..........QECVEECRVWKGLP
E7CXR8_RAT/505-637--VCNPLCSSEG--------------------CWGPEP------TDCVSCQNVSRG..........RECVDKCNILEGEP
ERBB3_RAT/499-630--VCDPLCSSGG--------------------CWGPGP------GQCLSCRNYSRE..........GVCVTHCNFLQGEP
Q153D8_XENLA/509-641--KCFSRCAGEQ--------------------CWGPGP------SQCVRCNGFLRG..........HDCIESCNIQDGIP
Q2HZD7_CHICK/500-631--VCDPLCSADG--------------------CWGPGP------AQCLSCRHYSRR..........GVCVESCSFTQGET
F1QYI3_DANRE/475-607--ICDPLCSEAG--------------------CWGPGP------DQCLSCKYFSRG..........KTCVKSCNLYYGDV
E1C0S3_CHICK/428-563--VCDPLCSDVG--------------------CWGPGP------FHCFSCRFFSRQ..........KECVKQCNILQGEP
Q23821_CAERE/560-683--ICDPNCNSRG--------------------CWGKRP------EDCRECRTWNNM..........GTCVSKCDTIGFLR
E9QC99_DANRE/495-628--VCDPLCSDAG--------------------CWGPGP------EQCLSCRNYSRL..........GTCVSHCNLYSGEP
A5A753_PIG/500-632--ICNPLCSSEG--------------------CWGPEP------RDCMSCRNFSRG..........KECVEKCNVLEGEP
D0RB24_NOTVI/501-633--ICDLLCSDNG--------------------CWGPGP------FSCLSCRYFLRM..........TECVETCNIMKGEP
B4LLF8_DROVI/581-693--VCSDQCNSDG--------------------CWGAGP------DQCLNCKSFNYN..........GTCIADCRNV...T
B0V0R6_DANRE/423-555--VCDPLCSDAG--------------------CWGPGP------DQCLSCRFFIRG..........RTCVESCNLHEGDV
B3MC66_DROAN/584-696--VCSDQCNEDG--------------------CWGAGP------DQCLNCKNFNYS..........GTCIADCRNI...S
Q153D7_XENLA/91-223--VCDTLCSEEG--------------------CWGPGP------SQCVSCLKYIRG..........KECVENCNFLSREP
Q9BIH9_ANOGA/471-584--ECSEQCSKAG--------------------CWGKGP------EQCLECKNVKYK..........GKCLDSCKSL...P
E2CA29_HARSA/483-596--VCNEECSDEG--------------------CWGPGP------AQCLSCKNVKLG..........NDCLQDCTA....P
Q6VQA3_DANRE/503-635--TCNEMCTADD--------------------CWGPGP------TMCFSCEHYSRG..........KHCVASCNLLNGEP
Q4RWY4_TETNG/474-606--ICDRKCTAEG--------------------CWGPGP------DMCFTCSDYSRG..........GSCVDSCNILEGES
E3NFJ5_CAERE/507-626--ICDPNCNSRG--------------------CWGKQP------EDCLECRTWNNM..........GTCVSSQCDIGYFG
P79754_TAKRU/494-627--VCDPLCSDSG--------------------CWGPGP------DQCLSCRNYSRH..........GTCVAGCHFNSGIP
E3X4M2_ANODA/494-602--QCSEQCTTAG--------------------CWGKGP------EQCLECKNFVYE..........GKCLDSCKSL...P
Q153D9_XENLA/519-651--VCDPFCSNIG--------------------CWGPGA------NQCLSCRYFSRG..........KSCVRSCNLCKGES
A8WPC3_CAEBR/574-697--VCDPNCNKRG--------------------CWGKRP------NDCLECRTWNNM..........GSCVSKCDTVGFLR
F2U6Q9_SALS5/180-312--PCSSLCN.GA--------------------CWGPGD------HQCLSCADSAVAIVQAQAGVVHVTCADTCP.....D
Q4RG29_TETNG/491-621--VCHRLCK.GG--------------------CWGPGP------GQCASCETFQRG..........TECVEHCDIYQGSV
Q9YH40_XIPXI/501-633--TCNNECSEDG--------------------CWGPGP------TMCVSCLHVDRG..........GRCVASCNLLQGEP

PF00757

INSR_HUMAN/179-340NEECGDICPGTA.KGKTNCPATVINGQFVER.CWTHS........HCQ..................KVCPTICKS.HGCT
Q1LVG4_DANRE/171-332DLECGNICPGTI.AGTISCKQTT.INGNFGERCWNQN........HCQ..................RICPSECVH.GACT
INSR_AEDAE/196-357NGSKQKCPAAPV.RGGNKDH.......KRTL.CWNAN........HCQ..................TICPPECPK..ACS
Q4RG29_TETNG/162-318AQNCP.........NCSSQC.......LTS..CWGEAA......QDCQTL..............TRSNCASGCQ...RCK
Q2HZD7_CHICK/183-335GRACA.........PCHESC.......GGH..CWGPGP......EDCQQL..............TKTICAPQCNG..RCF
Q6SAA1_DROME/154-303ERECP.........KCHESC.......THG..CWGEGP......KNCQKF..............SKLTCSPQCAG.GRCY
Q9W6F6_CHICK/31-183SSGCG.........RCHKSC.......TGR..CWGPTE......NHCQTL..............TKTVCAEQCDG..RCY
O93457_PSEMX/181-336SKECSDVCPGIM.ENNPQCRKTM.FNSNYNYRCWNSN........KCQ..................KECPERCAR.QACT
Q6QMR8_DANRE/182-336GKNCG.........KCDPSC.......FNGS.CWGTGP......DKCQRM..............TKVIYAERCSG..RCK
ILPR_BRALA/178-321EEECVNFCPGRC.RIKHPVLQ....DL.....CWAEE........HCQ..................KVCPESCLG..NCR
IGF1R_XENLA/172-329PKECVDLCPGAR.EKMQICEKSS.INNEFADRCWSDE........HCQ..................KVCPSVCGK.RACS
Q4S8B8_TETNG/198-353SKECSDVCPGVM.ESSPQCRKTV.FNNNYSYRCWNSN........HCQ..................RECPDKCGR.RACT
Q4RUB0_TETNG/145-331DRECGDVCPGTA.QGQTICPQNT.INGHFRGRCWSQN........HCQRTGLPVGKSGLKGCTMCLRVCGENCKH.STCT
Q2EJ72_CHICK/180-332SRTCP.........DCRALC.......AEGH.CWGESP......QDCQTL..............TNSIC.HGCP...RCK
A2IRM8_CYNPY/177-334PKECGDLCPGAM.EAKPLCEKTS.INYEYSRRCWSAN........HCQ..................KVCPPECGK.GACT
Q4RWY4_TETNG/154-308NPQCQ.........KCHSSC.......FNGS.CWAPGS......QNCQQL..............TKLNCAQQCSR..RCN
Q9YH40_XIPXI/187-340ERQCQ.........KCDPGC.......VNGS.CWAPGP......GHCQKF..............TKLLCAEQCNR..RCR
INSRR_HUMAN/173-329GEECADVCPGVLGAAGEPCAKTT.FSGHTDYRCWTSS........HCQ..................RVCP..CPHGMACT
Q1LWJ4_DANRE/181-336SKECGDVCPGIN.EDRPHCIRTS.FNDNYSYRCWTSN........HCQ..................KVCPKECEK.RACT
Q6PA47_XENLA/176-333VEECSDVCPGIR.DFGESCVKTP.INGNVESRCWTST........SCQ..................KVC..NCGKDIACS
ERBB2_CANFA/189-343FSACP.........PCSPAC.......KDAH.CWGASS......GDCQSL..............TRTVCAGGCA...RCK
Q8MIL8_PIG/184-338LGSCP.........KCDPGC.......LNGS.CWGAGK......ENCQKL..............TKVICAQQCSG..RCR
Q4H3N3_CIOIN/233-394DRYCD.........PCPSVCRDD.SGSTPVNRCWGNSS......DLCQLI..............TKSKCRRQCGN.DRCN
Q8UW85_PAROL/178-344DRECGDVCPGAA.LGKTTCQTTT.INGHFSERCWTQK........HCQ..................KMCPVQCKH.RACT
Q9NJV5_BIOGL/183-333SKQPCPVCRSNC.EPRN...............CWSYD........QCQ..................KGFTCSCKANQGCM
Q4REV4_TETNG/149-304PEECDNVCPGIMVKDEPLCQRTS.FNDNHDARCWTSN........HCQ..................KVCPERCKL..ACT
INSR_XENLA/189-350KEECGDVCPGTV.KGKSKCKHTL.VNGALVERCWTQD........HCQ..................KVCPSDCKG.SGCL
MIPR_LYMST/206-359KEQCPNSCKDEC.QSKR...............CWTYS........DCQ..................KGLNCQCKENTYCM
Q86MD7_ECHMU/215-366NTTCHSACSEND.EKGH...............CWGPEK......NQCQL................RSKCTKESTT..YCR
P79754_TAKRU/177-329NGERG.........VCHKSC.......GNY..CWGPGK......DQCQIL..............TKTVCAPQCND..RCF
Q8UW84_PAROL/181-335AKECDNVCPGIM.EDNPLCKRTL.FNDNYDYRCWTST........QCQ..................KVCPEHCKF..ACT
Q5EBY4_DANRE/181-338PKNCP.........RCSSAC.......KSGG.CWGEKD......QDCQTL..............TSVNCSSGCS...RCK
LET23_CAEEL/214-369GKSMA.........KCHESC........NDK.CWGSGD......NDCQRV..............YRSVCPKSCS...QCF
Q153D8_XENLA/183-342HRQCP.........LCSPACGSL.PSGRSGL.CWGVGQ......EYCQTL..............TSTICDSGCQ...RCK
A6P6W2_COTJA/175-333PKECGDLCPGTM.EEKPLCEKTS.INNEYNYRCWTTN........HCQ..................KMCPSSCGK.RACT
HTK7_HYDVU/189-344KGHCHPAPGHDG.DPKAQY.............CWGPGPKKQQNKAQCQ..................RFCNTQCGP.EGCL
Q17D67_AEDAE/155-304ERDCP.........PCHSSC.......EVG..CWGEGA......HNCQKF..............SKLNCSPQCSQ.GRCF
Q7Q0F6_ANOGA/194-348LRDVNRLIHNEK.ASHL...............CWSTN........HCQ..................QKCPAHCPK..SCN
Q4RXV8_TETNG/185-366NGPEK.........PCHKAC.......GDVP.CWGPGS......DMCQIL..............TKTVCAPQCNF..RCF
INSR_DROME/509-648NASCQLHNNRRL....................CWNSK........LCQ..................TKCPEKCRN..NCI

PF14843

Q6SAX4_DROME/471-583NAYKFDNRTCKICH-PEC.........RTC------NGAG-ADHCQECVHVR.......D--..GQHCVSECPKN.....
F1M7X4_RAT/502-634REFEN.GSICVECD-SQCEKMEDGL..LTC------HGPG-PDNCTKCSHFK.......D--..GPNCVEKCPDGLQ.GA
E0W212_PEDHC/466-580GMYTAGPNLCKPCH-EECA........STC------FGPG-NGNCTKCKHVR.......D--..GPFCYSSCPET.....
Q923V5_RAT/34-167REYVS.DKRCLPCH-PECQPQNSS...ETC------FGSE-ADQCAACAHYK.......D--..SSSCVARCPSGVKPDL
E7CXR8_RAT/505-637REFVE.NSECIQCH-PECLPQTMN...ITC------TGRG-PDNCIKCAHYV.......D--..GPHCVKTCPSGIM.GE
ERBB3_RAT/499-630REFVH.EAQCFSCH-PECLPMEGT...STC------NGSG-SDACARCAHFR.......D--..GPHCVNSCPHGIL.GA
Q153D8_XENLA/509-641REHVN.GSQCVPCH-SQCHPQNGS...LTC------SGPE-ASQCIECAHYM.......D--..GEDCVEHCPSGVK.GS
Q2HZD7_CHICK/500-631REFAE.GTECFECH-PECERVEGG...ITC------NGSG-ADTCTRCAHYR.......D--..GPHCVERCPEGIL.GE
F1QYI3_DANRE/475-607REFAN.GSVCVECD-SQCEKAGEKG..LTC------HGPG-PDHCVKCLHLK.......D--..GPNCVEKCPDGLQ.GA
E1C0S3_CHICK/428-563REFER.DSKCLPCH-SECLVQNSTAYNTTC------SGPG-PDHCMKCAHFI.......D--..GPHCVKACPAGVL.GE
Q23821_CAERE/560-683NQT...SMKCQKCS-PEC.........ETC------NGLG-EFDCLSCRHYTLYNSDFGN--..RMECVSDCPTST....
E9QC99_DANRE/495-628REFAASNKECLACH-SECLLQNGK...QTC------LGKG-ADQCVACSNLM.......D--..GPHCVSSCPNGVN.GE
A5A753_PIG/500-632REFVE.NAECVQCH-PECLPQAKN...VTC------MGRG-PDSCVRCAHYI.......D--..GPHCVKTCPAGIA.GE
D0RB24_NOTVI/501-633REYVK.DSKCFRCH-PECLIQNTT...TTC------TGPG-PDNCLACAHFK.......D--..GPHCVKSCPSGIM.GE
B4LLF8_DROVI/581-693KTYQFDAKTCKKCH-PEC.........RTC------SGPG-AEHCDECVHVR.......D--..DQHCVTVCPEN.....
B0V0R6_DANRE/423-555REFAN.GSVCLECD-AQCEVPEDDA..LTC------TGPG-PDHCVKCRHFK.......D--..GPNCVEKCPDGLQ.GA
B3MC66_DROAN/584-696NAYRHDSKTCRICH-EEC.........KTC------SGPG-AEDCDECVHVR.......D--..EQHCVSECPEN.....
Q153D7_XENLA/91-223RGYTV.DGRCFSCN-VECLQLNDT...QTC------SGPG-ADECFKCAHYS.......D--..GPFCVKTCPAGIH.GE
Q9BIH9_ANOGA/471-584RLYSVDSKTCGDCH-QECK........DFC------YGPN-EDNCGSCMNVK.......D--..GRFCVAECPTT.....
E2CA29_HARSA/483-596GIYRADEKTCKTCH-VECD........GSC------TGPN-AEQCTKCKHVR.......D--..GPFCVPECPSS.....
Q6VQA3_DANRE/503-635REYEV.NKTCMECD-PECLLMNET...QTC------NGPG-PDKCTVCANYK.......D--..GPHCVHRCPQGVP.GE
Q4RWY4_TETNG/474-606RETVV.NKTCVKCH-PECERMNGT...TTC------SAPG-SGNCTRCANFQ.......D--..GLFCVSRCPRGVP.GE
E3NFJ5_CAERE/507-626NQT...SMTCEKCS-PEC.........ETC------NGLG-EFDCLSCRHYTFYNPNFGN--..RMECVSDCPTHT....
P79754_TAKRU/494-627REFAGLNGVCVACH-PECKPQTGK...ASC------TGPG-ADECMACTKFR.......D--..GPYCMSSCPAGVNDGE
E3X4M2_ANODA/494-602RIYQVNSKTCEDCH-PECK........DFC------YGPN-ADNCGSCVNVK.......D--..GKFCVSECPIM.....
Q153D9_XENLA/519-651REFAN.GSVCVKCD-PQCEKIDEGM..ATC------YGAG-PDHCTKCSSFK.......D--..GPNCVEKCPEGLQ.GA
A8WPC3_CAEBR/574-697NQT...SMRCQPCS-PEC.........KTC------NGIG-EFDCLSCRHFTLYNPEFGN--..RMECVESCPKAT....
F2U6Q9_SALS5/180-312GTYEDDTRVCRTCD-AAC.........ATC------SGPS-STSCGSCVAFA.......D--TTTSTCVSSCPHDAY.AS
Q4RG29_TETNG/491-621REYAS.ESLCVACH-PECQPLNGS...ASC------HGPG-AEHCVECRKFQ.......D--..GDFCVDHCPSGVK..E
Q9YH40_XIPXI/501-633REAQV.DGRCVQCH-QECLVQTDS...LTC------YGPG-PANCSKCAHFQ.......D--..GPQCIPRCPHGML.GD

PF00757

INSR_HUMAN/179-340.....AEGLC--CH.SECL--------GNC......SQPDDPTKCVACRNFY-------L....DGRCVETCPP......
Q1LVG4_DANRE/171-332.....SHKEC--CH.EQCL--------GGC......SVPGNSTKCVACRNFL-------Y....GEACVDRCPP......
INSR_AEDAE/196-357.....KTGVC--CDAESCL--------GGC......NLPN.TSSCSVCRHLS-------IDPAGKRQCVAKCPP......
Q4RG29_TETNG/162-318G...FLPNDC--CH.KQCA--------AGC......TGPK.DSDCLACRHFN-------D....SGVCKENCPPPTTYDP
Q2HZD7_CHICK/183-335G...RAPNEC--CH.EECA--------GGC......TGPL.QTHCFACRHFN-------D....SGACVPLCPQPLIYNK
Q6SAA1_DROME/154-303G...PKPREC--CH.LFCA--------GGC......TGPT.QKDCIACKNFF-------D....EGVCKEECPPMRKYNP
Q9W6F6_CHICK/31-183G...PYVSDC--CH.RECA--------GGC......SGPK.DTDCFACMNFN-------D....SGACVTQCPQTFVYNP
O93457_PSEMX/181-336.....ADGEC--CH.PQCL--------GSC......TAPGSDTACAACVHYY-------H....QGRCVAECPP......
Q6QMR8_DANRE/182-336G...PRPIDC--CN.EHCA--------AGC......TGPR.PTDCLACKDFQ-------D....EGTCKDACPRLMLYDP
ILPR_BRALA/178-321....DGISGC--CH.ENCI--------GGC......DGPT.ERDCVACKYFV-------H....NGECLIQCPP......
IGF1R_XENLA/172-329.....DNNEC--CH.PECL--------GSC......TAPDNDTACVACHHYF-------Y....EGRCVPTCPS......
Q4S8B8_TETNG/198-353.....ADGQC--CH.PQCL--------GSC......TRAGSDAACAACVHYY-------H....HGRCVAQCPP......
Q4RUB0_TETNG/145-331.....LQGQC--CH.DQCL--------GGC......SEPGNASSCVACRNLL-------H....ANTCVEKCPP......
Q2EJ72_CHICK/180-332G...TKPTDC--CH.EQCA--------AGC......TGPK.HSDCLACLNFN-------R....SGICELHCPPLVIYNS
A2IRM8_CYNPY/177-334.....DQKQC--CH.AECL--------GSC......SMPDNDTACVACRHFF-------Y....EGRCLATCPP......
Q4RWY4_TETNG/154-308G...PAPSNC--CN.EHCA--------AGC......TGPR.ATDCLACRDFQ-------D....DGVCKDSCPGLIRYDP
Q9YH40_XIPXI/187-340G...PKPIDC--CN.EHCA--------GGC......TGPR.ATDCLACRDFN-------D....DGTCKDTCPPPKIYDI
INSRR_HUMAN/173-329.....ARGEC--CH.TECL--------GGC......SQPEDPRACVACRHLY-------F....QGACLWACPP......
Q1LWJ4_DANRE/181-336.....DAGQC--CH.PQCL--------GSC......TEADNDKACAACQHYF-------H....EDRCVEACPP......
Q6PA47_XENLA/176-333.....NTGEC--CH.SECL--------GGC......NKADDPRACVACRNFY-------I....DDQCLASCPR......
ERBB2_CANFA/189-343G...PQPTDC--CH.EQCA--------AGC......TGPK.HSDCLACLHFN-------H....SGICELHCPALVTYNT
Q8MIL8_PIG/184-338G...RSPSDC--CH.NQCA--------AGC......TGPR.ESDCLVCRRFR-------D....EATCKDTCPPLMLYNP
Q4H3N3_CIOIN/233-394.....AGGAC--CN.GKCA--------GGCYDNMPATGNK.DKWCHACKDMN-------N....NGTCVEACPQGTQMNP
Q8UW85_PAROL/178-344.....KDDQC--CH.DQCL--------GGC......LQPNSASHCVACRGLQ-------L....EGNCVDRCPE......
Q9NJV5_BIOGL/183-333.....ANGAC--CH.EYCL--------GGC......KGPT.AEDCYSCKYVS-------F....NNSCLSECPP......
Q4REV4_TETNG/149-304.....DQGEC--CH.SQCL--------GSC......TEPNNDMACSACLHYH-------H....EGRCVQDCPP......
INSR_XENLA/189-350.....PDGQC--CH.PECL--------GSC......RKPNDPSECTACRHFQ-------N....EGVCVTACPK......
MIPR_LYMST/206-359.....ENGSC--CH.DYCL--------GGC......KVPMNPDECFSCKEVQ-------F....NNTCRPQCPP......
Q86MD7_ECHMU/215-366LD.NPFERIK--CD.DACI--------GGC......NGS..TSNCWACRSKR-------N....GDTCVSFCPPRHHVNP
P79754_TAKRU/177-329G...TSPRDC--CH.IECA--------AGC......KGPL.DTDCFACRLFN-------D....SGACVPQCPQTLIYNK
Q8UW84_PAROL/181-335.....DKGEC--CH.SQCL--------GTC......TEPNNDMACSACLHYF-------H....EDRCVPDCPL......
Q5EBY4_DANRE/181-338G...PKPSDC--CH.VQCA--------AGC......TGPK.DSDCLACRHFN-------D....SGTCKDSCPPPTIYDP
LET23_CAEEL/214-369YSNSTSSYEC--CD.SACL--------GGC......TGHG.PKNCIACSKYE-------L....DGICIETCPSRKIFNH
Q153D8_XENLA/183-342G...NHSTHC--CH.EQCA--------AGC......TGPK.NSDCLACLLFN-------H....SGVCGTHCPPLSTYNP
A6P6W2_COTJA/175-333.....DQNEC--CH.PECL--------GSC......TAPDNNTACVACRNYY-------Y....EGVCMPTCPP......
HTK7_HYDVU/189-344D...GSDHIC--CH.HECL--------GGC......SAINSTNTCHACRKYR-------IK..STGQCVSKCPR......
Q17D67_AEDAE/155-304G...SKPREC--CH.LFCA--------GGC......TGPT.QKDCLACKNFY-------D....DGVCKQECPPMQRYNP
Q7Q0F6_ANOGA/194-348.....KTGEC--CS.TSCL--------GQC......SSNN.KSHCMVCRKYY-------YIHNNQTRCVDKCPD......
Q4RXV8_TETNG/185-366G...RSPGEC--CH.SECA--------GGC......TGPL.DTDCFACRKFN-------D....SGSCVPQCPMALIYNK
INSR_DROME/509-648.....DEHTC--CS.QDCL--------GGC.....VIDKNGNESCISCRNVS-------F....NNICMDSCPK......

PF14843

Q6SAX4_DROME/471-583.....-----.KYND.RGVCR------------------------------------------------ECHATC..DG-
F1M7X4_RAT/502-634NS.FI-----FKYADQDRECH------------------------------------------------PCHPNC.TQG-
E0W212_PEDHC/466-580.....-----.KYND.NGECK------------------------------------------------SCHPNC.VNG-
Q923V5_RAT/34-167SYMPI-----WKYPDEEGICQ------------------------------------------------PCPINC.THS-
E7CXR8_RAT/505-637NNTLV-----WKFADANNVCH------------------------------------------------LCHANC.TYG-
ERBB3_RAT/499-630KG.PI-----YKYPDAQNECR------------------------------------------------PCHENC.TQG-
Q153D8_XENLA/509-641SFVPI-----WKFPDKDKICQ------------------------------------------------LCPVNC.SHL-
Q2HZD7_CHICK/500-631RG.PI-----YKYPDSSRECR------------------------------------------------PCHENC.TRG-
F1QYI3_DANRE/475-607NS.FI-----FKYAETNNECH------------------------------------------------PCHPNC.TQG-
E1C0S3_CHICK/428-563NDTLV-----WKYADANAVCQ------------------------------------------------LCHPNC.TRG-
Q23821_CAERE/560-683.....-----.HYSTTKNVCE------------------------------------------------RCHPTCYENG-
E9QC99_DANRE/495-628KGQTI-----FKYSTAAGHCE------------------------------------------------LCHFNC.TRG-
A5A753_PIG/500-632NSTLI-----WKFADANHVCH------------------------------------------------LCHPNC.TYG-
D0RB24_NOTVI/501-633NDTYI-----WKYADENKVCQ------------------------------------------------LCHVNC.TEG-
B4LLF8_DROVI/581-693.....-----.KYSD.FGICR------------------------------------------------RCHETC..EG-
B0V0R6_DANRE/423-555SS.FI-----FKYAEANNECH------------------------------------------------PCHVNC.TQG-
B3MC66_DROAN/584-696.....-----.KYSD.NGICR------------------------------------------------KCHATC..EG-
Q153D7_XENLA/91-223NNSLI-----WKYPDENGACQ------------------------------------------------LCHPEC.KLG-
Q9BIH9_ANOGA/471-584.....-----.KHAM.NGTCI------------------------------------------------NCHKTC..VG-
E2CA29_HARSA/483-596.....-----.KYND.SGECK------------------------------------------------HCHQNC.VGG-
Q6VQA3_DANRE/503-635KDTLI-----WKYADVTHVCQ------------------------------------------------PCHENC.TQG-
Q4RWY4_TETNG/474-606DDMLV-----WKYADNNKVCQ------------------------------------------------LCHRNC.TQG-
E3NFJ5_CAERE/507-626.....-----.RCSTIGNVCE------------------------------------------------K....CYENG-
P79754_TAKRU/494-627KG.LI-----FKFPNREGHCE------------------------------------------------PCHQNC.TQG-
E3X4M2_ANODA/494-602.....-----.KYAL.NGTCV------------------------------------------------KCHKTC..VG-
Q153D9_XENLA/519-651NS.FI-----FKYADEDKECH------------------------------------------------PCHPNC.TDG-
A8WPC3_CAEBR/574-697.....-----.YFSTEDDVCE------------------------------------------------KCHATCYENG-
F2U6Q9_SALS5/180-312PTAPV-----GFGTTAPEYCM------------------------------------------------PCNAMC..DG-
Q4RG29_TETNG/491-621DHQTV-----WKYSNATGHCL------------------------------------------------PCNTNC.TLS-
Q9YH40_XIPXI/501-633GDTLI-----WKYADKMGQCQ------------------------------------------------PCHQNC.TQG-

PF00757

INSR_HUMAN/179-340..........PYYHFQDWRCVNFSFCQDLHHK...............CKNSRRQGCHQYVI.....HNNKCIPEC-PSGY
Q1LVG4_DANRE/171-332..........GYYTFKSWRCVSLQFCQDLHN................QCKDKSGDCHAYVI.....HNGACIPEC-PSGY
INSR_AEDAE/196-357..........NTFKY.HTRCVTRDECYAMKKPI.............SLDSNPDLPDQPFIP.....HNGSCLMEC-PLDH
Q4RG29_TETNG/162-318ATFQSKPNPDRKFSF.GATCV..KTCP............................YNYLAM.....DV.ACTLNY-PKPN
Q2HZD7_CHICK/183-335LTFQLEPNPDTKYQY.GSVCV..RSCP............................HNFVV......DQSSCVRAC-PSNK
Q6SAA1_DROME/154-303TTYVLETNPEGKYAY.GATCV..KECP.............................GHLLR.....DNGACVRSC-PQDK
Q9W6F6_CHICK/31-183TTFQLEHNHNAKYTY.GAFCV..KKCP............................HNFVV......DSSSCVRAC-PSSK
O93457_PSEMX/181-336..........GTYKFEDWRCISAELCSK......................VHLPEYDSFII.....HGEECMPEC-PSGY
Q6QMR8_DANRE/182-336NTHQLAPNPYGKYSF.GATCI..KTCP............................HNYVVT.....DHGACVRTC-SPGT
ILPR_BRALA/178-321..........DTYQYKDRRCITEEECP.........................NTTNSVWKL.....HHRKCIPEC-PSGY
IGF1R_XENLA/172-329..........NTYKFEGWRCITREVCAKM....................HIWIHSTIPFII.....HKGECVYEC-PSGY
Q4S8B8_TETNG/198-353..........GTYRFEGWRCVSVDFCSK......................VHLPDPHTFVL.....HGQECMPEC-PSGY
Q4RUB0_TETNG/145-331..........GYFIFRGWRCVSFSFCQELHNQCKQ.........IKKLNQDIEPGCSEYVI.....HDGACIPEC-PSGY
Q2EJ72_CHICK/180-332DTFESVPNRDGRYTF.GASCV..SQCP............................YNYLAT.....EVGSCTLVC-PQNS
A2IRM8_CYNPY/177-334..........HTYMFEGWRCVSREFCARV....................PSSDTDYEPYVI.....HKGECMPEC-PSGF
Q4RWY4_TETNG/154-308NLHQLVPNPHGKYNF.GAKCV..KTCP............................HNYVVT.....DHGACVRTC-SGNT
Q9YH40_XIPXI/187-340VSHQVVDNPNIKYTF.GAACV..KECP............................SNYVVT.....E.GACVRSC-SAGM
INSRR_HUMAN/173-329..........GTYQYESWRCVTAERCASL....................HSVPGRASTFGI.....HQGSCLAQC-PSGF
Q1LWJ4_DANRE/181-336..........DTYKFEGWRCITMEMCAR......................VHLPSEVDFVI.....HNGECMPDC-PPGF
Q6PA47_XENLA/176-333..........GTYEYEGWRCIKKAYCSNLRK.................ESENSQESTKFVI.....FENRCLSEC-PPGY
ERBB2_CANFA/189-343DTFESMPNPEGRYTF.GASCV..TSCP............................YNYLST.....DVGSCTLVC-PLNN
Q8MIL8_PIG/184-338TTYQMDVNPLGKYSF.GATCV..KKCP............................RNYVVT.....DHGSCVRAC-SSDS
Q4H3N3_CIOIN/233-394T..STITKTPKTYQF.ARYCV..PKCP.............................FNVPQ.....TTSFCRTYC-PEGT
Q8UW85_PAROL/178-344..........NHFTFKGWRCVTFAFCQDLHNKCK...........REKERAKNPDCHEYVI.....HNGACVADC-PSGY
Q9NJV5_BIOGL/183-333..........ATYRYKGRRCLTDRECLSL.....................PYQSGKAPMLLVGEKGEPSQCVFYC-PQNY
Q4REV4_TETNG/149-304..........GTYKFEGWRCITMDACSQ......................VHLLGDTQFVI.....HEGECMLEC-PSGF
INSR_XENLA/189-350..........GSYQFQGWRCIDFNTCQELNSR...............CQNSRDNSCPPYVI.....HKGECMPDC-PSGY
MIPR_LYMST/206-359..........GTYKFLNRRCLTDKECLAL....................TNDPDGNTPKLLDGEKGEPSLCLYTC-PQNY
Q86MD7_ECHMU/215-366TTSRQELNPDFKYEL.HDICV..RQCP.............................EPLLK.....MDTVCVIEC-DFKT
P79754_TAKRU/177-329QTFQMETNPNAKYQY.GSICV..SQCP............................THFVV......DGSSCVSVC-PPDK
Q8UW84_PAROL/181-335..........GTYKFESWRCITMDLCSQ......................VHLPGDPQFVI.....HGGECMHDC-PSGF
Q5EBY4_DANRE/181-338ITFQSKPNKDKKFSF.GATCV..KQCP............................HNYLAM.....EV.ACTMVC-PKAN
LET23_CAEEL/214-369KTGRLVFNPDGRYQN.GNHCV..KECP.............................PELLI.....ENDVCVRHC-SDGH
Q153D8_XENLA/183-342ETYESVHNEGGRYTF.GASCV..TSCP............................YNYLAT.....EVGSCTLFC-PKDN
A6P6W2_COTJA/175-333..........NTYKFEGWRCVTKEFCSKVP...................ATETSDYERFVI.....HNDECMAEC-PSGF
HTK7_HYDVU/189-344..........KQYLVDKFLCQ..ESCPYW.....................SINSTEYHHYL.....WQGECVTKC-PVNY
Q17D67_AEDAE/155-304TNYLWEPNPEGKYAY.GATCV..RNCP.............................EHLLK.....DNGACVRTC-PSNK
Q7Q0F6_ANOGA/194-348..........HMFLFSESRCLTEEECYKIYKPLQ...........RIADITD...NYPYVP.....AQGECRLDC-PLGY
Q4RXV8_TETNG/185-366YTFRLEPNPNAKFQF.GSICV..AQCPRQYPPRLLRLKSASSFVFIPALLCFLYSANFLV......DGTSCVRSC-PADK
INSR_DROME/509-648..........GYYQF.DSRCVTANECITLT...................KFETNSVYSGIP.....YNGQCITHC-PTGY

PF14843

Q6SAX4_DROME/471-583------------------CT-GP-KDTIGI
F1M7X4_RAT/502-634------------------CN-GP-TSHDCI
E0W212_PEDHC/466-580------------------CT-GP-ENTIGP
Q923V5_RAT/34-167------------------CV-DL-DERGCP
E7CXR8_RAT/505-637------------------CA-GP-GLKGCQ
ERBB3_RAT/499-630------------------CN-GP-ELQDCL
Q153D8_XENLA/509-641------------------CN-QM-DERGCP
Q2HZD7_CHICK/500-631------------------CT-GP-LLQDCL
F1QYI3_DANRE/475-607------------------SV-AC-NRFRCR
E1C0S3_CHICK/428-563------------------CK-GP-GLEGCP
Q23821_CAERE/560-683------------------CT-GS-DSNLGH
E9QC99_DANRE/495-628------------------CT-GP-ALRDCV
A5A753_PIG/500-632------------------CV-GP-GLEGCA
D0RB24_NOTVI/501-633------------------CF-GP-DLEGCP
B4LLF8_DROVI/581-693------------------CT-GP-NNTIGH
B0V0R6_DANRE/423-555------------------CT-GP-RLQDCI
B3MC66_DROAN/584-696------------------CT-GP-KDTIGL
Q153D7_XENLA/91-223------------------CA-GH-GIDGCP
Q9BIH9_ANOGA/471-584------------------CR-GP-RDTIAP
E2CA29_HARSA/483-596------------------CE-GP-ENNIGA
Q6VQA3_DANRE/503-635------------------CT-GP-DLKDCK
Q4RWY4_TETNG/474-606------------------CT-GP-GLAGCQ
E3NFJ5_CAERE/507-626------------------LH-TR-SSDALH
P79754_TAKRU/494-627------------------CS-GP-GLNDCL
E3X4M2_ANODA/494-602------------------M.-..-..SWSA
Q153D9_XENLA/519-651------------------CR-GP-RLKDCI
A8WPC3_CAEBR/574-697------------------CT-GP-SSNLGP
F2U6Q9_SALS5/180-312------------------CF-GP-SNADCA
Q4RG29_TETNG/491-621------------------CT-VK-DERGCP
Q9YH40_XIPXI/501-633------------------CS-GP-GLSGCR

PF00757

INSR_HUMAN/179-340TMN.......SSNLLCTPCL.GP.CPKVCH
Q1LVG4_DANRE/171-332TTVN......STSLTCMPCT.GR.CPKVCT
INSR_AEDAE/196-357ELITE....LNKTRWCRKCS.GT.CPKRCE
Q4RG29_TETNG/162-318PKDVVPQPCGNDTQKCEKCE.GD.CPKVCY
Q2HZD7_CHICK/183-335MEVE.....KNGLKMCEPCA.GL.CPKACE
Q6SAA1_DROME/154-303M.........DKGGECVPCN.GP.CPKTCP
Q9W6F6_CHICK/31-183MEVE.....ENGIKMCKPCT.DI.CPKACD
O93457_PSEMX/181-336TRTT......PDSMTCTACD.GL.CDKVCE
Q6QMR8_DANRE/182-336YEVD.....EGGVRKCKRCE.GL.CPKGTT
ILPR_BRALA/178-321TTDI......NNPRLCTECE.GQ.CPKSCK
IGF1R_XENLA/172-329MLNK......SQSMTCSPCE.GP.CPKICE
Q4S8B8_TETNG/198-353TRST......TDNMSCTACD.GL.CDKVCE
Q4RUB0_TETNG/145-331TTIN......TTTLTCSPCA.GL.CPKLCL
Q2EJ72_CHICK/180-332QEVT.....VNNVQKCEKCS.KP.CPEVCY
A2IRM8_CYNPY/177-334TRNG......SQSMFCSPCE.GP.CPKICE
Q4RWY4_TETNG/154-308YEIE.....EGGIRKCAKCD.GL.CPKVCN
Q9YH40_XIPXI/187-340LEVD.....ENGKRSCKPCD.GV.CPKVCD
INSRR_HUMAN/173-329TRN.......SSSIFCHKCE.GL.CPKECK
Q1LWJ4_DANRE/181-336TRNE......TQSMFCSACD.GL.CDKVCE
Q6PA47_XENLA/176-333TR........NDSILCHKCV.GL.CPKTCK
ERBB2_CANFA/189-343QEVTA....EDGTQRCEKCS.KP.CARVCY
Q8MIL8_PIG/184-338YEVE.....EDGVRKCKKCD.GP.CGKVCN
Q4H3N3_CIOIN/233-394FD........YNSNICEPCENGK.CEHVCY
Q8UW85_PAROL/178-344TTVN......SSSLNCMPCA.GL.CPKVCM
Q9NJV5_BIOGL/183-333TIREL...KEKNYNECVKCT.GF.CHKECS
Q4REV4_TETNG/149-304KRNE......TNQMFCSACN.GP.CDKSCR
INSR_XENLA/189-350IAN.......STTRTCTPCA.GP.CPKVCT
MIPR_LYMST/206-359SVGDSK..DNKNLSQCVKCR.QL.CPKECH
Q86MD7_ECHMU/215-366TI........PVNGSCVPCA.KTPCANHCE
P79754_TAKRU/177-329MEVE.....RGSQRQCELCS.GL.CPKVCE
Q8UW84_PAROL/181-335TRNE......TNRMFCSACN.GL.CDKVCT
Q5EBY4_DANRE/181-338KEVISVEPDGQETQKCEKCE.GE.CPKVCY
LET23_CAEEL/214-369HYDA.....TKDVRECEKCR.SSSCPKICT
Q153D8_XENLA/183-342KEVI.....VGNMQKCEKCD.KQ.CSKVCY
A6P6W2_COTJA/175-333IRNG......SQSMFCSPCE.GP.CPKICE
HTK7_HYDVU/189-344ISN.......NQTKKCEKCKSGMKCNTVCK
Q17D67_AEDAE/155-304M.........AQNGECVPCN.GA.CPKTCQ
Q7Q0F6_ANOGA/194-348TLTRA...TGSQRLACVPCK.GP.CRSECK
Q4RXV8_TETNG/185-366MEVE.....KNGVKRCEPCG.GL.CPKACH
INSR_DROME/509-648QKS.......ENKRMCEPCPGGK.CDKECS

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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