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31  structures 190  species 4  interactions 13225  sequences 892  architectures

Clan: CUB (CL0164)

Summary

CUB clan Add an annotation

This clan contains the CUB domain [1,2].

This clan contains 2 families and the total number of domains in the clan is 13225. The clan was built by A Bateman.

Literature references

  1. Bork P, Beckmann G; , J Mol Biol 1993;231:539-545.: The CUB domain. A widespread module in developmentally regulated proteins. PUBMED:8510165 EPMC:8510165
  2. Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ; , Nat Struct Biol 1997;4:783-788.: The crystal structures of two spermadhesins reveal the CUB domain fold. PUBMED:9334740 EPMC:9334740

Members

This clan contains the following 2 member families:

CUB CUB_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CUB (PF00431) 12961 (98.0%) View
CUB_2 (PF02408) 264 (2.0%) View
Total: 2 Total: 13225 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
CUB EGF
CUB
F5_F8_type_C
EGF_CA

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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